Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 4. Effects of anoctamin 1 (ANO1) or Ca2+-activated Cl- channel blocker on ML204 (an inhibitor of transient receptor potential canonical 4 and 5 [TRPC4/5] channels)-induced action in small intestinal interstitial cells of Cajal. (A) Transmembrane member 16A (TMEM16A) blocker (ANO1 blocker; 10 μM) did not show any influence on pacemaker potentials but blocked ML204-induced action. (B) Ca2+-activated Cl- channel (CACC) blocker (10 μM) did not show any influence on pacemaker potentials but blocked ML204-induced action.
J Neurogastroenterol Motil 2020;26:521~528 https://doi.org/10.5056/jnm20064
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