Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 5. Inhibition of nitric oxide synthase (NOS) increases constriction to a similar extent in C57BL/10 and mdx mice. Resting colon diameter (mm) and constricted colon diameter (mm) in the presence of 100 μM N-nitro-L-arginine (NOLA) were measured for the proximal colon, the mid colon, and the distal colon after video recording and spatiotemporal mapping of colons excised from C57BL/10 and mdx mice receiving either the control diet (A, E) or a diet supplemented with 1% L-alanine (B, F), L-citrulline (C, G), or L-arginine (D, H). Statistical analysis was performed using a 2-way ANOVA with a Bonferonni’s post-hoc multiple comparisons test to determine the effects of genotype and colon region. ****P < 0.0001 colon region main effect; n = 9–12/genotype/group.
Journal of Neurogastroenterology and Motility 2020;26:133~146
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