Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 2. The distal colon of mdx mice exhibits increased contraction frequency which is attenuated by administration of L-arginine (Arg) or L-citrulline (Cit). Four-week-old male C57BL/10 and mdx mice received either a control (Cont) diet or a diet supplemented with 1% L-alanine (Ala), L-citrulline, or L-arginine for 8 weeks. After treatment, colons were excised and contractions assessed ex vivo by video recording and ST mapping of colon diameter (A). The number of colonic migrating motor complexes (CMMCs; defined as contractions propagating more than half the length of the colon) were determined from the ST maps (B). Contraction frequency (number of contractions per 15-minute recording) was determined for the proximal colon (C), the mid colon (D), and the distal colon (E). Statistical analysis was performed using a Kruskal-Wallis test to assess effects of treatment. *P < 0.05, **P < 0.01 relative to C57BL/10 control, n = 9–12/genotype/group.
Journal of Neurogastroenterology and Motility 2020;26:133~146 https://doi.org/10.5056/jnm19029
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