Fig. 3. Beneficial effects and possible adverse effects need to be balanced, when proton pump inhibitors (PPIs) are administered as many other drugs. Beneficial effects of PPIs for the long-term treatment of gastroesophageal reflux disease (GERD) and prevention of aspirin/non-steroidal anti-inflammatory drug (NSAID)-induced ulcers are strong enough when PPIs are administered only to appropriate patients. PPIs also have several acid-inhibition related and unrelated adverse effects although the clinical impacts of these adverse events are not so serious. However, balancing beneficial and adverse effects as well as selecting appropriate patients who will get larger benefits by the PPIs administration are critically important. SIBO, small intestinal bacterial overgrowth.
© J Neurogastroenterol Motil
