Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 3. Interaction between cholecystokinin-8 (CCK-8) and leptin on nodose neuronal firing, and the effect of JMV-180 on this interaction. Intraarterial infusion of CCK-8 (10 pmol) (A) did not stimulate vagal nodose neuronal firing. CCK-8 at 120 pmol (B) and leptin at 225 pmol (C) increased the neuronal discharge frequency. (D) A synergistic effect was observed when CCK and leptin were infused together. (E, F) Administration of JMV-180 but not CCK-8 prevented this potentiation effect, which suggests that low-affinity CCK-A receptors are coexpressed with leptin receptors in rat nodose ganglia. Adapted from Li et al.96
J Neurogastroenterol Motil 2011;17:338~348
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