Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 1. Neuroanatomically discrete populations of leptin receptor expressing neurons mediate distinct components of leptin action. The hypothalamic nuclei, including the arcuate, dorsomedial, ventromedial, lateral hypothalamic area and ventral premammillary (PMv) nuclei play an important role in the regulation of satiety and glycemic control. The hindbrain including the nucleus of the solitary tract which is activated by the vagal afferent pathway may also regulate satiety. In addition, leptin differentially regulates 2 populations of thyrotropin releasing hormone-expressing neurons in the paraventral nucleus to modulate thyroid hormone secretion via the hypothalamic-pituitary axis. Leptin also acts on neurons in the PMv and medial preoptic area to regulate reproductive function by modulating gonadotropin releasing hormone secretion. NTS, nucleus of the solitary tract; VTA, ventral tegmental area; LHA, lateral hypothalamic area; ARC, arcuate; VMH, ventromedial; PVN, paraventral nucleus; MPOA, medial preoptic area. Modified figure adopted from Robertson et al64 with permission from Elsevier.
J Neurogastroenterol Motil 2011;17:338~348
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