Fig. 1. Study design. (A) All subjects randomly received a capsule containing placebo or 18 mg of hydrochloride quinine in a randomized, double blind, cross-over design. (B) The ad libitum test started 60 minutes after capsule administration. Blood samples were taken to assay ghrelin and cholecystokinin at T0, T60, and T90. Gastrointestinal sensation assessment was performed at T0, T60, and at the end of ad libitum test (Tend). GI, gastrointestinal; HCl, hydrochloride; PTC, phenylthiocarbamide.
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