Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Cited by CrossRef (137)

  1. Hanna Ferløv Schwensen, Carol Kan, Janet Treasure, Niels Høiby, Magnus Sjögren. A systematic review of studies on the faecal microbiota in anorexia nervosa: future research may need to include microbiota from the small intestine. Eat Weight Disord 2018;23:399
    https://doi.org/10.1007/s40519-018-0499-9
  2. Clive H Wilder-Smith, Søren S Olesen, Andrea Materna, Asbjørn M Drewes. Breath methane concentrations and markers of obesity in patients with functional gastrointestinal disorders. United European Gastroenterol. j. 2018;6:595
    https://doi.org/10.1177/2050640617744457
  3. Jin Won Kim, Seon-Young Park, Jin Ook Chung, Hyun A Cho, Dong-Hyun Kim, Jae Hyun Yoon, Chang Hwan Park, Hyun Soo Kim, Sung Kyu Choi, Jong Sun Rew. Influencing Factors on Lactulose Breath Test Results. Korean J Gastroenterol 2020;75:23
    https://doi.org/10.4166/kjg.2020.75.1.23
  4. Shane T. O'Donnell, R.P. Ross, Elke K. Arendt, Catherine Stanton. Comprehensive Gut Microbiota. 2020.
    https://doi.org/10.1016/B978-0-12-819265-8.00093-0
  5. Mengze Li, Gabriel Bekö, Nora Zannoni, Giovanni Pugliese, Mariana Carrito, Nicoletta Cera, Catarina Moura, Pawel Wargocki, Priscila Vasconcelos, Pedro Nobre, Nijing Wang, Lisa Ernle, Jonathan Williams. Human metabolic emissions of carbon dioxide and methane and their implications for carbon emissions. Science of The Total Environment 2022;833:155241
    https://doi.org/10.1016/j.scitotenv.2022.155241
  6. Florencia Ceppa, Andrea Mancini, Kieran Tuohy. Current evidence linking diet to gut microbiota and brain development and function. International Journal of Food Sciences and Nutrition 2019;70:1
    https://doi.org/10.1080/09637486.2018.1462309
  7. Lydia C. Garas, M. Kristina Hamilton, Matthew W. Dawson, Jane-Ling Wang, James D. Murray, Helen E. Raybould, Elizabeth A. Maga. Lysozyme-rich milk mitigates effects of malnutrition in a pig model of malnutrition and infection. Br J Nutr 2018;120:1131
    https://doi.org/10.1017/S0007114518002507
  8. Corinna Bang, Tal Dagan, Peter Deines, Nicole Dubilier, Wolfgang J. Duschl, Sebastian Fraune, Ute Hentschel, Heribert Hirt, Nils Hülter, Tim Lachnit, Devani Picazo, Lucia Pita, Claudia Pogoreutz, Nils Rädecker, Maged M. Saad, Ruth A. Schmitz, Hinrich Schulenburg, Christian R. Voolstra, Nancy Weiland-Bräuer, Maren Ziegler, Thomas C.G. Bosch. Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?. Zoology 2018;127:1
    https://doi.org/10.1016/j.zool.2018.02.004
  9. Katelyn E. Madigan, Richa Bundy, Richard B. Weinberg. Distinctive Clinical Correlates of Small Intestinal Bacterial Overgrowth with Methanogens. Clinical Gastroenterology and Hepatology 2022;20:1598
    https://doi.org/10.1016/j.cgh.2021.09.035
  10. Vanessa Demonfort Nkamga, Bernard Henrissat, Michel Drancourt. Archaea: Essential inhabitants of the human digestive microbiota. Human Microbiome Journal 2017;3:1
    https://doi.org/10.1016/j.humic.2016.11.005
  11. Christof Schneider, Klaus D. Wutzke, Jan Däbritz. Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption. Sci Rep 2020;10
    https://doi.org/10.1038/s41598-020-75987-6
  12. Gustavo Andrade de PAULO, Fernanda Prata Borges MARTINS, Erika Pereira de MACEDO, Manoel Ernesto Peçanha GONÇALVES, Angelo Paulo FERRARI. SAFETY OF MANNITOL USE IN BOWEL PREPARATION: a prospective assessment of intestinal methane (CH4) levels during colonoscopy after mannitol and sodium phosphate (NaP) bowel cleansing. Arq. Gastroenterol. 2016;53:196
    https://doi.org/10.1590/S0004-28032016000300014
  13. Leilei Yu, Hui Duan, Yaqi Yu, Qingsong Zhang, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Fengwei Tian, Wei Chen. Dose-dependent effects of chronic lead toxicity in vivo: Focusing on trace elements and gut microbiota. Chemosphere 2022;301:134670
    https://doi.org/10.1016/j.chemosphere.2022.134670
  14. Tim J. Knobbe, Rianne M. Douwes, Daan Kremer, J. Casper Swarte, Michele F. Eisenga, António W. Gomes-Neto, Marco van Londen, Frans T. M. Peters, Hans Blokzijl, Ilja M. Nolte, Wouter H. Hendriks, Hermie J. M. Harmsen, Stephan J. L. Bakker. Altered Gut Microbial Fermentation and Colonization with Methanobrevibacter smithii in Renal Transplant Recipients. JCM 2020;9:518
    https://doi.org/10.3390/jcm9020518
  15. Ilan J.N. Koppen, Sophie Kuizenga-Wessel, Miguel Saps, Carlo Di Lorenzo, Marc A. Benninga, Faridi S. van Etten–Jamaludin, Merit M. Tabbers. Functional Defecation Disorders and Excessive Body Weight: A Systematic Review. 2016;138
    https://doi.org/10.1542/peds.2016-1417
  16. Carolina Piedade MARTINS, Caio Henrique Amorim CHAVES, Maurício Gustavo Bravim de CASTRO, Isabel Cristina GOMES, Maria do Carmo Friche PASSOS. PREVALENCE OF SMALL INTESTINE BACTERIAL OVERGROWTH IN PATIENTS WITH GASTROINTESTINAL SYMPTOMS. Arq. Gastroenterol. 2017;54:91
    https://doi.org/10.1590/s0004-2803.201700000-06
  17. Ricardo Correa BARBUTI, Leonardo Lucca SCHIAVON, Cláudia P OLIVEIRA, Mário Reis ALVARES-DA-SILVA, Lígia Yukie SASSAKI, Maria do Carmo F PASSOS, Alberto Queiroz FARIAS, Luisa Leite BARROS, Bruno Paes BARRETO, Gisela Bandeira de Melo Lins de ALBUQUERQUE, Amanda Mandarino ALVES, Tomás NAVARRO-RODRIGUEZ, Paulo Lisboa BITTENCOURT. GUT MICROBIOTA, PREBIOTICS, PROBIOTICS, AND SYNBIOTICS IN GASTROINTESTINAL AND LIVER DISEASES: PROCEEDINGS OF A JOINT MEETING OF THE BRAZILIAN SOCIETY OF HEPATOLOGY (SBH), BRAZILIAN NUCLEUS FOR THE STUDY OF HELICOBACTER PYLORI AND MICROBIOTA (NBEHPM), AND BRAZILIAN FEDERATION OF GASTROENTEROLOGY (FBG). Arq. Gastroenterol. 2020;57:381
    https://doi.org/10.1590/s0004-2803.202000000-72
  18. H. Duboc, M. Dior, B. Coffin. Le syndrome de l’intestin irritable : nouvelles pistes physiopathologiques et conséquences pratiques. La Revue de Médecine Interne 2016;37:536
    https://doi.org/10.1016/j.revmed.2015.12.030
  19. Leonard B Weinstock, Jill B Brook, Trisha L Myers, Brent Goodman. Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment. BMJ Case Reports 2018:bcr-2017-221405
    https://doi.org/10.1136/bcr-2017-221405
  20. Kourosh Kalantar-Zadeh, Kyle J. Berean, Rebecca E. Burgell, Jane G. Muir, Peter R. Gibson. Intestinal gases: influence on gut disorders and the role of dietary manipulations. Nat Rev Gastroenterol Hepatol 2019;16:733
    https://doi.org/10.1038/s41575-019-0193-z
  21. Ali Rezaie, Mark Pimentel, Satish S. Rao. How to Test and Treat Small Intestinal Bacterial Overgrowth: an Evidence-Based Approach. Curr Gastroenterol Rep 2016;18
    https://doi.org/10.1007/s11894-015-0482-9
  22. Courtney M. Thomas, Elie Desmond-Le Quéméner, Simonetta Gribaldo, Guillaume Borrel. Factors shaping the abundance and diversity of the gut archaeome across the animal kingdom. Nat Commun 2022;13
    https://doi.org/10.1038/s41467-022-31038-4
  23. Prashant Singh, Anthony Lembo. Emerging Role of the Gut Microbiome in Irritable Bowel Syndrome. Gastroenterology Clinics of North America 2021;50:523
    https://doi.org/10.1016/j.gtc.2021.03.003
  24. Nicolas Richard, Charlotte Desprez, Fabien Wuestenberghs, Anne‐Marie Leroi, Guillaume Gourcerol, Chloé Melchior. The effectiveness of rotating versus single course antibiotics for small intestinal bacterial overgrowth. United European Gastroenterol. j. 2021;9:645
    https://doi.org/10.1002/ueg2.12116
  25. Erika Ruback BERTGES, Júlio Maria Fonseca CHEBLI. PREVALENCE AND FACTORS ASSOCIATED WITH SMALL INTESTINAL BACTERIAL OVERGROWTH IN PATIENTS WITH CROHN’S DISEASE: A RETROSPECTIVE STUDY AT A REFERRAL CENTER. Arq. Gastroenterol. 2020;57:283
    https://doi.org/10.1590/s0004-2803.202000000-64
  26. Lai Wei, Rajan Singh, Seungil Ro, Uday C Ghoshal. Gut microbiota dysbiosis in functional gastrointestinal disorders: Underpinning the symptoms and pathophysiology. JGH Open 2021;5:976
    https://doi.org/10.1002/jgh3.12528
  27. Steven Hubert, Alan Chadwick, Vince Wacher, Olivia Coughlin, John Kokai-Kun, Andrew Bristol. Development of a Modified-Release Formulation of Lovastatin Targeted to Intestinal Methanogens Implicated in Irritable Bowel Syndrome With Constipation. Journal of Pharmaceutical Sciences 2018;107:662
    https://doi.org/10.1016/j.xphs.2017.09.028
  28. Han Seung Ryu, Suck Chei Choi. Recent Updates on the Treatment of Constipation. Intest Res 2015;13:297
    https://doi.org/10.5217/ir.2015.13.4.297
  29. Jae Hak Kim, Eugenia Lin, Mark Pimentel. Biomarkers of Irritable Bowel Syndrome. J Neurogastroenterol Motil 2017;23:20
    https://doi.org/10.5056/jnm16135
  30. Stefano Romano, George M. Savva, Janis R. Bedarf, Ian G. Charles, Falk Hildebrand, Arjan Narbad. Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation. npj Parkinsons Dis. 2021;7
    https://doi.org/10.1038/s41531-021-00156-z
  31. Marietta Zita Poles, László Juhász, Mihály Boros. Methane and Inflammation - A Review (Fight Fire with Fire). ICMx 2019;7
    https://doi.org/10.1186/s40635-019-0278-6
  32. Asaf Rotbart, C.K. Yao, Nam Ha, Michael D. Chrisp, Jane G. Muir, Peter R. Gibson, Kourosh Kalantar-zadeh, Jian Zhen Ou. Designing an in-vitro gas profiling system for human faecal samples. Sensors and Actuators B: Chemical 2017;238:754
    https://doi.org/10.1016/j.snb.2016.07.120
  33. Mirjana Rajilić-Stojanović, Daisy M Jonkers, Anne Salonen, Kurt Hanevik, Jeroen Raes, Jonna Jalanka, Willem M de Vos, Chaysavanh Manichanh, Natasa Golic, Paul Enck, Elena Philippou, Fuad A Iraqi, Gerard Clarke, Robin C Spiller, John Penders. Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?. 2015;110:278
    https://doi.org/10.1038/ajg.2014.427
  34. Jun-Ke Wang, Shu-Kun Yao, Duygu Ağagündüz. Roles of Gut Microbiota and Metabolites in Pathogenesis of Functional Constipation. Evidence-Based Complementary and Alternative Medicine 2021;2021:1
    https://doi.org/10.1155/2021/5560310
  35. Zainab Alyousif, Daniela Rivero Mendoza, Jérémie Auger, Vanessa De Carvalho, Samantha Amos, Charles Sims, Wendy J Dahl. Gastrointestinal Tolerance and Microbiome Response to Snacks Fortified with Pea Hull Fiber: A Randomized Trial in Older Adults. 2020;4
    https://doi.org/10.1093/cdn/nzaa005
  36. Jakub Ruszkowski, Jacek M. Witkowski. Lactulose: Patient- and dose-dependent prebiotic properties in humans. Anaerobe 2019;59:100
    https://doi.org/10.1016/j.anaerobe.2019.06.002
  37. Lenka Tomasova, Piotr Konopelski, Marcin Ufnal. Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis. Molecules 2016;21:1558
    https://doi.org/10.3390/molecules21111558
  38. Emily C. Hoedt, Páraic Ó Cuív, Mark Morrison. Methane matters: from blue-tinged moos, to boozy roos, and the health of humans too. 2016;6:15
    https://doi.org/10.2527/af.2016-0029
  39. Maria do Carmo Friche PASSOS, Ricardo Cerqueira ALVARIZ, Eduardo Antonio ANDRÉ, Ricardo Correa BARBUTI, Henrique Sarubbi FILLMANN, Sthela Maria MURAD-REGADAS, Joffre REZENDE FILHO, Marcos PERROTTI, Luciana GUEDES. DIAGNOSIS AND MANAGEMENT OF CHRONIC IDIOPATHIC CONSTIPATION: A NARRATIVE REVIEW FROM A BRAZILIAN EXPERT TASK FORCE. Arq. Gastroenterol. 2022;59:137
    https://doi.org/10.1590/s0004-2803.202200001-23
  40. Daniela Polag, Frank Keppler. Long-term monitoring of breath methane. Science of The Total Environment 2018;624:69
    https://doi.org/10.1016/j.scitotenv.2017.12.097
  41. Sheyda Ranjbar, Seyed Afshin Seyednejad, Shekoufeh Nikfar, Roja Rahimi, Mohammad Abdollahi. How can we develop better antispasmodics for irritable bowel syndrome?. Expert Opinion on Drug Discovery 2019;14:549
    https://doi.org/10.1080/17460441.2019.1593369
  42. Zaki Saati‐Santamaría, Isabel Revilla‐Martín, Paula García‐Fraile, Carlos Palacios‐Riocerezo. Evolution and predicted functions of the microbiota of the medium‐slow growing chicken during the first 4 weeks of chick development. Annals of Applied Biology 2022;181:9
    https://doi.org/10.1111/aab.12760
  43. Rohit Sharma, Yogesh Nimonkar, Ashutosh Sharma, Rajesh Singh Rathore, Om Prakash. Microbial Resource Conservation. 2022.
    https://doi.org/10.1007/978-3-319-96971-8_2
  44. Qi Zhang, Wen Zhao, Yuyang Zhao, Sufang Duan, Wei-Hsien Liu, Chao Zhang, Siyuan Sun, Tingting Wang, Xin Wang, Wei-Lian Hung, Ran Wang. In vitro Study of Bifidobacterium lactis BL-99 With Fructooligosaccharide Synbiotics Effected on the Intestinal Microbiota. Front. Nutr. 2022;9
    https://doi.org/10.3389/fnut.2022.890316
  45. Georgios Tziatzios, Evangelos J. Giamarellos-Bourboulis, Ioannis S. Papanikolaou, Mark Pimentel, George D. Dimitriadis, Konstantinos Triantafyllou. Is small intestinal bacterial overgrowth involved in the pathogenesis of functional dyspepsia?. Medical Hypotheses 2017;106:26
    https://doi.org/10.1016/j.mehy.2017.07.005
  46. Brian Ginnebaugh, William D. Chey, Richard Saad. Small Intestinal Bacterial Overgrowth. Gastroenterology Clinics of North America 2020;49:571
    https://doi.org/10.1016/j.gtc.2020.04.010
  47. Julia Leszkowicz, Katarzyna Plata-Nazar, Agnieszka Szlagatys-Sidorkiewicz. Can Lactose Intolerance Be a Cause of Constipation? A Narrative Review. Nutrients 2022;14:1785
    https://doi.org/10.3390/nu14091785
  48. Lindsay Joy Spielman, Deanna Lynn Gibson, Andis Klegeris. Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases. Neurochemistry International 2018;120:149
    https://doi.org/10.1016/j.neuint.2018.08.005
  49. Wenkang Gao, Yixin Zhu, Jin Ye, Huikuan Chu. Gut non-bacterial microbiota contributing to alcohol-associated liver disease. Gut Microbes 2021;13
    https://doi.org/10.1080/19490976.2021.1984122
  50. Aleksandr Birg, Steve Hu, Henry C Lin. Reevaluating our understanding of lactulose breath tests by incorporating hydrogen sulfide measurements. JGH Open 2019;3:228
    https://doi.org/10.1002/jgh3.12145
  51. András T. Mészáros, Tamás Büki, Borbála Fazekas, Eszter Tuboly, Kitti Horváth, Marietta Z. Poles, Szilárd Szűcs, Gabriella Varga, József Kaszaki, Mihály Boros. Inhalation of methane preserves the epithelial barrier during ischemia and reperfusion in the rat small intestine. Surgery 2017;161:1696
    https://doi.org/10.1016/j.surg.2016.12.040
  52. Kenneth Brown, Brandi Scott-Hoy, Linda W Jennings. Response of irritable bowel syndrome with constipation patients administered a combined quebracho/conker tree/M. balsamea Willdextract. WJGPT 2016;7:463
    https://doi.org/10.4292/wjgpt.v7.i3.463
  53. Robert Šket, Tadej Debevec, Susanne Kublik, Michael Schloter, Anne Schoeller, Boštjan Murovec, Katarina Vogel Mikuš, Damjan Makuc, Klemen Pečnik, Janez Plavec, Igor B. Mekjavić, Ola Eiken, Zala Prevoršek, Blaž Stres. Intestinal Metagenomes and Metabolomes in Healthy Young Males: Inactivity and Hypoxia Generated Negative Physiological Symptoms Precede Microbial Dysbiosis. Front. Physiol. 2018;9
    https://doi.org/10.3389/fphys.2018.00198
  54. Ayesha Shah, Gerald Holtmann. Small intestinal bacterial overgrowth in inflammatory bowel disease. Indian J Gastroenterol 2022;41:23
    https://doi.org/10.1007/s12664-021-01235-y
  55. Jae-Hwan Jang, Mi-Jung Yeom, Sora Ahn, Ju-Young Oh, Suhwan Ji, Tae-Hong Kim, Hi-Joon Park. Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson’s disease. Brain, Behavior, and Immunity 2020;89:641
    https://doi.org/10.1016/j.bbi.2020.08.015
  56. Paraskevas Gkolfakis, George Dimitriadis, Konstantinos Triantafyllou. Gut microbiota and non-alcoholic fatty liver disease. Hepatobiliary & Pancreatic Diseases International 2015;14:572
    https://doi.org/10.1016/S1499-3872(15)60026-1
  57. Marietta Zita Poles, Nikolett Bódi, Mária Bagyánszki, Éva Fekete, András Tamás Mészáros, Gabriella Varga, Szilárd Szűcs, Anna Nászai, Liliána Kiss, Andrey V. Kozlov, Mihály Boros, József Kaszaki. Reduction of nitrosative stress by methane: Neuroprotection through xanthine oxidoreductase inhibition in a rat model of mesenteric ischemia-reperfusion. Free Radical Biology and Medicine 2018;120:160
    https://doi.org/10.1016/j.freeradbiomed.2018.03.024
  58. Sarah R. Bloor, Rudolph Schutte, Anthony R. Hobson. Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota. Microbiology Research 2021;12:491
    https://doi.org/10.3390/microbiolres12020033
  59. Gillian M. Barlow, Allen Yu, Ruchi Mathur. Role of the Gut Microbiome in Obesity and Diabetes Mellitus. Nutr Clin Pract 2015;30:787
    https://doi.org/10.1177/0884533615609896
  60. E. Sogodogo, M. Drancourt, Ghiles Grine. Methanogens as emerging pathogens in anaerobic abscesses. Eur J Clin Microbiol Infect Dis 2019;38:811
    https://doi.org/10.1007/s10096-019-03510-5
  61. Yingmu Tong, Yanyan Dong, Yang Feng, Zeyu Li, Yifan Jia, Xing Zhang, Kai Qu, Chang Liu, Jingyao Zhang. Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock. Oxidative Medicine and Cellular Longevity 2019;2019:1
    https://doi.org/10.1155/2019/4929107
  62. Hyo Jeong Lee, Jong Kyoung Choi, Han Seung Ryu, Chang Hwan Choi, Eun Hee Kang, Kyung Sik Park, Yang Won Min, Kyoung Sup Hong. Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders. J Neurogastroenterol Motil 2017;23:9
    https://doi.org/10.5056/jnm16124
  63. Gerald Holtmann, Ayesha Shah, Mark Morrison. From trash to gold: gastrointestinal microbiome research in patients with functional gastrointestinal disorders. J Investig Med 2021;69:793
    https://doi.org/10.1136/jim-2021-001903
  64. Mohamed Zeineldin, Ameer Megahed, Benjamin Blair, Brian Aldridge, James Lowe. Metagenomic Analysis of the Fecal Archaeome in Suckling Piglets Following Perinatal Tulathromycin Metaphylaxis. Animals 2021;11:1825
    https://doi.org/10.3390/ani11061825
  65. Muhammad Zarrar Khan, Ruishen Lyu, John McMichael, Scott Gabbard. Chronic Intestinal Pseudo-Obstruction Is Associated with Intestinal Methanogen Overgrowth. Dig Dis Sci 2022
    https://doi.org/10.1007/s10620-021-07343-1
  66. Khara Lucius. “Brain Fog”: Exploring a Symptom Commonly Encountered in Clinical Practice. Alternative and Complementary Therapies 2021;27:23
    https://doi.org/10.1089/act.2020.29313.klu
  67. Dorines Rosario, Gholamreza Bidkhori, Sunjae Lee, Janis Bedarf, Falk Hildebrand, Emmanuelle Le Chatelier, Mathias Uhlen, Stanislav Dusko Ehrlich, Gordon Proctor, Ullrich Wüllner, Adil Mardinoglu, Saeed Shoaie. Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson’s disease. Cell Reports 2021;34:108807
    https://doi.org/10.1016/j.celrep.2021.108807
  68. Ling Zhao, Yufen Huang, Lin Lu, Wei Yang, Tao Huang, Zesi Lin, Chengyuan Lin, Hiuyee Kwan, Hoi Leong Xavier Wong, Yang Chen, Silong Sun, Xuefeng Xie, Xiaodong Fang, Huanming Yang, Jian Wang, Lixin Zhu, Zhaoxiang Bian. Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats. Microbiome 2018;6
    https://doi.org/10.1186/s40168-018-0492-6
  69. Aline Hajj, Diane Mourad, May Ghossoub, Souheil Hallit, Antoine Geagea, Halim Abboud, Hanna El Mouallem, Philippe Saniour, Nabil El Hachem, Lydia Rabbaa Khabbaz. Uncovering Demographic, Clinical, Triggering Factors Similarities Between Migraine and Irritable Bowel Syndrome. J Nerv Ment Dis 2019;207:847
    https://doi.org/10.1097/NMD.0000000000001033
  70. C.O. Guindo, M. Drancourt, G. Grine. Digestive tract methanodrome: Physiological roles of human microbiota-associated methanogens. Microbial Pathogenesis 2020;149:104425
    https://doi.org/10.1016/j.micpath.2020.104425
  71. Georgios Tziatzios, Paraskevas Gkolfakis, Ioannis S. Papanikolaou, Ruchi Mathur, Mark Pimentel, Georgia Damoraki, Evangelos J. Giamarellos-Bourboulis, George Dimitriadis, Konstantinos Triantafyllou. High Prevalence of Small Intestinal Bacterial Overgrowth among Functional Dyspepsia Patients. Dig Dis 2021;39:382
    https://doi.org/10.1159/000511944
  72. Liang Chen, Jun Wang. Gut microbiota and inflammatory bowel disease. WIREs Mechanisms of Disease 2022;14
    https://doi.org/10.1002/wsbm.1540
  73. Cemal Yazici, Deniz Cagil Arslan, Rana Abraham, Kelly Cushing, Ali Keshavarzian, Ece A. Mutlu. Breath Methane Levels Are Increased Among Patients with Diverticulosis. Dig Dis Sci 2016;61:2648
    https://doi.org/10.1007/s10620-016-4174-6
  74. Minseok Seo, Jaeyoung Heo, Joon Yoon, Se-Young Kim, Yoon-Mo Kang, Jihyun Yu, Seoae Cho, Heebal Kim, Jonathan Braun. Methanobrevibacter attenuation via probiotic intervention reduces flatulence in adult human: A non-randomised paired-design clinical trial of efficacy. PLoS ONE 2017;12:e0184547
    https://doi.org/10.1371/journal.pone.0184547
  75. Ujjala Ghoshal, Ratnakar Shukla, Deepakshi Srivastava, Uday C Ghoshal. Irritable Bowel Syndrome, Particularly the Constipation-Predominant Form, Involves an Increase in Methanobrevibacter smithii, Which Is Associated with Higher Methane Production. Gut and Liver 2016;10:932
    https://doi.org/10.5009/gnl15588
  76. Anisa Shaker, Billy Peng, Edy Soffer. Pattern of methane levels with lactulose breath testing; can we shorten the test duration?. JGH Open 2021;5:809
    https://doi.org/10.1002/jgh3.12592
  77. Seema M. Patel, Melissa C. Young. The Identification and Management of Small Intestinal Bacterial Overgrowth. Physical Medicine and Rehabilitation Clinics of North America 2022
    https://doi.org/10.1016/j.pmr.2022.04.003
  78. Corinna Bang, Ruth A. Schmitz, Franz Narberhaus. Archaea associated with human surfaces: not to be underestimated. FEMS Microbiology Reviews 2015;39:631
    https://doi.org/10.1093/femsre/fuv010
  79. Adriana Cabal, Trudy M. Wassenaar, David W. Ussery. Gender Differences in the Pathogenesis and Management of Heart Disease. 2015.
    https://doi.org/10.1007/978-3-319-71135-5_7
  80. Ilan J.N. Koppen, Carlo Di Lorenzo, Miguel Saps, Phil G. Dinning, Desale Yacob, Marc A. Levitt, Marc A. Benninga. Childhood constipation: finally something is moving!. Expert Review of Gastroenterology & Hepatology 2016;10:141
    https://doi.org/10.1586/17474124.2016.1098533
  81. Eamonn M.M. Quigley, Robin C. Spiller. Constipation and the Microbiome: Lumen Versus Mucosa!. Gastroenterology 2016;150:300
    https://doi.org/10.1053/j.gastro.2015.12.023
  82. Jian Zhen Ou, Jeremy J. Cottrell, Nam Ha, Naresh Pillai, Chu K. Yao, Kyle J. Berean, Stephanie A. Ward, Danilla Grando, Jane G. Muir, Christopher J. Harrison, Udani Wijesiriwardana, Frank R. Dunshea, Peter R. Gibson, Kourosh Kalantar-zadeh. Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model. Sci Rep 2016;6
    https://doi.org/10.1038/srep33387
  83. Christine Moissl-Eichinger. Humane Archaeen: salutogen statt pathogen?. Biospektrum 2015;21:709
    https://doi.org/10.1007/s12268-015-0635-2
  84. Qian Zhou, Di Zhang, Heng Zhang, Xingyang Wan, Bang Hu, Qi Zou, Dan Su, Hui Peng, Dandan Huang, Donglin Ren. Effects of Xiao Chengqi Formula on Slow Transit Constipation by Assessing Gut Microbiota and Metabolomics Analysis in vitro and in vivo. Front. Pharmacol. 2022;13
    https://doi.org/10.3389/fphar.2022.864598
  85. Kyoung Sup Hong, Kee Wook Jung, Tae Hee Lee, Bong Eun Lee, Sun-Young Park, Jeong Eun Shin, Seong-Eun Kim, Kyung Sik Park, Suck Chei Choi. Current Issues on the Treatment of Chronic Constipation. Korean J Gastroenterol 2014;64:148
    https://doi.org/10.4166/kjg.2014.64.3.148
  86. Uday C. Ghoshal, Deepakshi Srivastava, Asha Misra. A randomized double-blind placebo-controlled trial showing rifaximin to improve constipation by reducing methane production and accelerating colon transit: A pilot study. Indian J Gastroenterol 2018;37:416
    https://doi.org/10.1007/s12664-018-0901-6
  87. Keiichi Sumida, Wei Ling Lau, Csaba P. Kovesdy, Kamyar Kalantar-Zadeh, Kourosh Kalantar-Zadeh. Microbiome modulation as a novel therapeutic approach in chronic kidney disease. 2021;30:75
    https://doi.org/10.1097/MNH.0000000000000661
  88. Ameen Eetemadi, Ilias Tagkopoulos. Methane and fatty acid metabolism pathways are predictive of Low-FODMAP diet efficacy for patients with irritable bowel syndrome. Clinical Nutrition 2021;40:4414
    https://doi.org/10.1016/j.clnu.2020.12.041
  89. Ruben A.T. Mars, Mary Frith, Purna C. Kashyap. Functional Gastrointestinal Disorders and the Microbiome—What Is the Best Strategy for Moving Microbiome-based Therapies for Functional Gastrointestinal Disorders into the Clinic?. Gastroenterology 2021;160:538
    https://doi.org/10.1053/j.gastro.2020.10.058
  90. Jeroen A. A. van de Pol, Niels van Best, Catherine A. Mbakwa, Carel Thijs, Paul H. Savelkoul, Ilja C. W. Arts, Mathias W. Hornef, Monique Mommers, John Penders. Gut Colonization by Methanogenic Archaea Is Associated with Organic Dairy Consumption in Children. Front. Microbiol. 2017;8
    https://doi.org/10.3389/fmicb.2017.00355
  91. E. Tuboly, R. Molnár, T. Tőkés, R. N. Turányi, P. Hartmann, A. T. Mészáros, G. Strifler, I. Földesi, A. Siska, A. Szabó, Á. Mohácsi, G. Szabó, M. Boros. Excessive alcohol consumption induces methane production in humans and rats. Sci Rep 2017;7
    https://doi.org/10.1038/s41598-017-07637-3
  92. Daniel Bushyhead, Eamonn M.M. Quigley. Small Intestinal Bacterial Overgrowth Pathophysiology and its Implications for Definition and Management. Gastroenterology 2022
    https://doi.org/10.1053/j.gastro.2022.04.002
  93. I. N. Zakharova, I. M. Osmanov, I. V. Berezhnaya, K. A. Koltsov, O. V. Dedikova, A. E. Kuchina, Yu. O. Sazanova. Prospects for using probiotics in the treatment of constipation in children. Med. sov. 2018:85
    https://doi.org/10.21518/2079-701X-2018-11-85-90
  94. Shino Shimura, Norihisa Ishimura, Hironobu Mikami, Eiko Okimoto, Goichi Uno, Yuji Tamagawa, Masahito Aimi, Naoki Oshima, Shuichi Sato, Shunji Ishihara, Yoshikazu Kinoshita. Small Intestinal Bacterial Overgrowth in Patients with Refractory Functional Gastrointestinal Disorders. J Neurogastroenterol Motil 2015;22:60
    https://doi.org/10.5056/jnm15116
  95. Christopher J Black, Alexander C Ford. Chronic idiopathic constipation in adults: epidemiology, pathophysiology, diagnosis and clinical management. Medical Journal of Australia 2018;209:86
    https://doi.org/10.5694/mja18.00241
  96. Bénédict Yanibada, Ulli Hohenester, Mélanie Pétéra, Cécile Canlet, Stéphanie Durand, Fabien Jourdan, Julien Boccard, Cécile Martin, Maguy Eugène, Diego P. Morgavi, Hamid Boudra. Inhibition of enteric methanogenesis in dairy cows induces changes in plasma metabolome highlighting metabolic shifts and potential markers of emission. Sci Rep 2020;10
    https://doi.org/10.1038/s41598-020-72145-w
  97. Mario Matijašić, Tomislav Meštrović, Hana Čipčić Paljetak, Mihaela Perić, Anja Barešić, Donatella Verbanac. Gut Microbiota beyond Bacteria—Mycobiome, Virome, Archaeome, and Eukaryotic Parasites in IBD. IJMS 2020;21:2668
    https://doi.org/10.3390/ijms21082668
  98. Marguerite J. Kutyla, Sam O’Connor, Luke F. Hourigan, Bradley Kendall, Amanda Whaley, Vera Meeusen, Gerald J. Holtmann. An Evidence-based Approach Towards Targeted Patient Education to Improve Bowel Preparation for Colonoscopy. 2020;54:707
    https://doi.org/10.1097/MCG.0000000000001286
  99. Yong Sung Kim, Tatsuya Unno, Byung-Yong Kim, Mi-Sung Park. Sex Differences in Gut Microbiota. World J Mens Health 2020;38:48
    https://doi.org/10.5534/wjmh.190009
  100. Elisabeth Sogodogo, Ogobara Doumbo, Gérard Aboudharam, Bourema Kouriba, Ousseynou Diawara, Hapssa Koita, Souleymane Togora, Michel Drancourt. First characterization of methanogens in oral cavity in Malian patients with oral cavity pathologies. BMC Oral Health 2019;19
    https://doi.org/10.1186/s12903-019-0929-8
  101. Gerardo Calderon, Robert M. Siwiec, Matthew E. Bohm, Thomas V. Nowak, John M. Wo, Anita Gupta, Huiping Xu, Andrea Shin. Delayed Gastric Emptying Is Not Associated with a Microbiological Diagnosis of Small Intestinal Bacterial Overgrowth. Dig Dis Sci 2021;66:160
    https://doi.org/10.1007/s10620-020-06153-1
  102. Phoebe E. Heenan, Jacqueline I. Keenan, Simone Bayer, Myrthe Simon, Richard B. Gearry. Irritable bowel syndrome and the gut microbiota. Journal of the Royal Society of New Zealand 2020;50:470
    https://doi.org/10.1080/03036758.2019.1695635
  103. Christine Moissl-Eichinger, Manuela Pausan, Julian Taffner, Gabriele Berg, Corinna Bang, Ruth A. Schmitz. Archaea Are Interactive Components of Complex Microbiomes. Trends in Microbiology 2018;26:70
    https://doi.org/10.1016/j.tim.2017.07.004
  104. Yu. O. Shulpekova, G. H. Babaeva, V. Yu. Rusyaev. Pathogenetic Substantiation of the Therapeutic Impact on Microbiota in Irritable Bowel Syndrome. Rossijskij žurnal gastroènterologii, gepatologii, koloproktologii 2019;29:7
    https://doi.org/10.22416/1382-4376-2019-29-4-7-14
  105. Yifan Jia, Zeyu Li, Chang Liu, Jingyao Zhang. Methane Medicine: A Rising Star Gas with Powerful Anti-Inflammation, Antioxidant, and Antiapoptosis Properties. Oxidative Medicine and Cellular Longevity 2018;2018:1
    https://doi.org/10.1155/2018/1912746
  106. Mihály Boros, Frank Keppler. Methane Production and Bioactivity-A Link to Oxido-Reductive Stress. Front. Physiol. 2019;10
    https://doi.org/10.3389/fphys.2019.01244
  107. Melissa A. Nickles, Aliza Hasan, Anastasia Shakhbazova, Sarah Wright, Cynthia J. Chambers, Raja K. Sivamani. Alternative Treatment Approaches to Small Intestinal Bacterial Overgrowth: A Systematic Review. The Journal of Alternative and Complementary Medicine 2021;27:108
    https://doi.org/10.1089/acm.2020.0275
  108. Ruchi Mathur, Gillian M Barlow. Obesity and the microbiome. Expert Review of Gastroenterology & Hepatology 2015;9:1087
    https://doi.org/10.1586/17474124.2015.1051029
  109. Ilan J. N. Koppen, Marc A. Benninga. Pediatric Neurogastroenterology. 2015.
    https://doi.org/10.1007/978-3-319-43268-7_42
  110. Mattea Müller, Gerben D. A. Hermes, Emanuel E. Canfora, Hauke Smidt, Ad A. M. Masclee, Erwin G. Zoetendal, Ellen E. Blaak. Distal colonic transit is linked to gut microbiota diversity and microbial fermentation in humans with slow colonic transit. American Journal of Physiology-Gastrointestinal and Liver Physiology 2020;318:G361
    https://doi.org/10.1152/ajpgi.00283.2019
  111. K. Gottlieb, V. Wacher, J. Sliman, M. Pimentel. Review article: inhibition of methanogenic archaea by statins as a targeted management strategy for constipation and related disorders. Aliment Pharmacol Ther 2016;43:197
    https://doi.org/10.1111/apt.13469
  112. Xiuying Zhang, Huanzi Zhong, Yufeng Li, Zhun Shi, Huahui Ren, Zhe Zhang, Xianghai Zhou, Shanmei Tang, Xueyao Han, Yuxiang Lin, Fangming Yang, Dan Wang, Chao Fang, Zuodi Fu, Lianying Wang, Shida Zhu, Yong Hou, Xun Xu, Huanming Yang, Jian Wang, Karsten Kristiansen, Junhua Li, Linong Ji. Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities. Nat Aging 2021;1:87
    https://doi.org/10.1038/s43587-020-00014-2
  113. Jian Zhen Ou, C.K. Yao, Asaf Rotbart, Jane G. Muir, Peter R. Gibson, Kourosh Kalantar-zadeh. Human intestinal gas measurement systems: in vitro fermentation and gas capsules. Trends in Biotechnology 2015;33:208
    https://doi.org/10.1016/j.tibtech.2015.02.002
  114. Michele Pier Luca Guarino, Michele Cicala, Lorenza Putignani, Carola Severi. Gastrointestinal neuromuscular apparatus: An underestimated target of gut microbiota. WJG 2016;22:9871
    https://doi.org/10.3748/wjg.v22.i45.9871
  115. Eirini Dimidi, S. Mark Scott, Kevin Whelan. Probiotics and constipation: mechanisms of action, evidence for effectiveness and utilisation by patients and healthcare professionals. Proc. Nutr. Soc. 2020;79:147
    https://doi.org/10.1017/S0029665119000934
  116. Charlotte De Geyter, Kris Van de Maele, Bruno Hauser, Yvan Vandenplas. Hydrogen and Methane Breath Test in the Diagnosis of Lactose Intolerance. Nutrients 2021;13:3261
    https://doi.org/10.3390/nu13093261
  117. Lin Zhao, Yan Wang, Guanfei Zhang, Tiantian Zhang, Jing Lou, Jiankang Liu. L-Arabinose Elicits Gut-Derived Hydrogen Production and Ameliorates Metabolic Syndrome in C57BL/6J Mice on High-Fat-Diet. Nutrients 2019;11:3054
    https://doi.org/10.3390/nu11123054
  118. Jingshen Tian, Weinan Xue, Huihui Yin, Nannan Zhang, Junde Zhou, Zhiping Long, Chengwei Wu, Zhengzi Liang, Kun Xie, Shuo Li, Liangliang Li, Zhen Wu, Volontovich Daria, Yashuang Zhao, Fan Wang, Maoqing Wang.

    Differential Metabolic Alterations and Biomarkers Between Gastric Cancer and Colorectal Cancer: A Systematic Review and Meta-Analysis

    . OTT 2020;Volume 13:6093
    https://doi.org/10.2147/OTT.S247393
  119. Peng Bin, Md. Abul Kalam Azad, Gang Liu, Dan Zhu, Sung Woo Kim, Yulong Yin. Effects of different levels of methionine on sow health and plasma metabolomics during late gestation. Food Funct. 2018;9:4979
    https://doi.org/10.1039/C8FO01477A
  120. Gregorio Peron, Giorgio Gargari, Tomás Meroño, Antonio Miñarro, Esteban Vegas Lozano, Pol Castellano Escuder, Raúl González-Domínguez, Nicole Hidalgo-Liberona, Cristian Del Bo’, Stefano Bernardi, Paul Antony Kroon, Barbara Carrieri, Antonio Cherubini, Patrizia Riso, Simone Guglielmetti, Cristina Andrés-Lacueva. Crosstalk among intestinal barrier, gut microbiota and serum metabolome after a polyphenol-rich diet in older subjects with “leaky gut”: The MaPLE trial. Clinical Nutrition 2021;40:5288
    https://doi.org/10.1016/j.clnu.2021.08.027
  121. Lei Yang, Yue Wan, Wenwen Li, Chen Liu, Hui-fang Li, Zhiling Dong, Ke Zhu, Shu Jiang, Erxin Shang, Dawei Qian, Jinao Duan. Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb. Appl Microbiol Biotechnol 2022;106:1615
    https://doi.org/10.1007/s00253-022-11813-5
  122. Bruno P. Chumpitazi, Erica M. Weidler, Robert J. Shulman. Lactulose Breath Test Gas Production in Childhood IBS Is Associated With Intestinal Transit and Bowel Movement Frequency. 2017;64:541
    https://doi.org/10.1097/MPG.0000000000001295
  123. Tamar Thurm, Yishai Ron. Gastrointestinal Motility Disorders. 2017.
    https://doi.org/10.1007/978-3-319-59352-4_32
  124. Jaspreet Suri, Rahul Kataria, Zubair Malik, Henry P. Parkman, Ron Schey. Elevated methane levels in small intestinal bacterial overgrowth suggests delayed small bowel and colonic transit. 2018;97:e10554
    https://doi.org/10.1097/MD.0000000000010554
  125. M. Bharathi, P. Chellapandi. Intergenomic evolution and metabolic cross-talk between rumen and thermophilic autotrophic methanogenic archaea. Molecular Phylogenetics and Evolution 2017;107:293
    https://doi.org/10.1016/j.ympev.2016.11.008
  126. Els Houben, Vicky De Preter, Jaak Billen, Marc Van Ranst, Kristin Verbeke. Additional Value of CH4 Measurement in a Combined 13C/H2 Lactose Malabsorption Breath Test: A Retrospective Analysis. Nutrients 2015;7:7469
    https://doi.org/10.3390/nu7095348
  127. Ali I. Mirza, Feng Zhu, Natalie Knox, Jessica D. Forbes, Gary Van Domselaar, Charles N. Bernstein, Morag Graham, Ruth Ann Marrie, Janace Hart, E. Ann Yeh, Douglas L. Arnold, Amit Bar-Or, Julia O'Mahony, Yinshan Zhao, William Hsiao, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett. Metagenomic Analysis of the Pediatric-Onset Multiple Sclerosis Gut Microbiome. Neurology 2022;98:e1050
    https://doi.org/10.1212/WNL.0000000000013245
  128. Mihály Boros, Eszter Tuboly, András Mészáros, Anton Amann. The role of methane in mammalian physiology—is it a gasotransmitter?. J. Breath Res. 2015;9:014001
    https://doi.org/10.1088/1752-7155/9/1/014001
  129. Prem Prashant Chaudhary, Patricia Lynne Conway, Jørgen Schlundt. Methanogens in humans: potentially beneficial or harmful for health. Appl Microbiol Biotechnol 2018;102:3095
    https://doi.org/10.1007/s00253-018-8871-2
  130. José E.R. Ricci, Liliana A. Chebli, Tarsila C.d.R. Ribeiro, Antonio C.S. Castro, Pedro D. Gaburri, Fabio H.d.L. Pace, Kátia V.B.D. Barbosa, Lincoln E.V.V.d.C. Ferreira, Maria d.C.F. Passos, Carla Malaguti, Álvaro H.d.A. Delgado, Jacqueline D. Campos, André R. Coelho, Julio M.F. Chebli. Small-Intestinal Bacterial Overgrowth is Associated With Concurrent Intestinal Inflammation But Not With Systemic Inflammation in Crohn’s Disease Patients. 2018;52:530
    https://doi.org/10.1097/MCG.0000000000000803
  131. Magnus Sjögren, Stein Frostad, Kenneth Klingenberg Barfod. Anorexia and Bulimia Nervosa. 2018.
    https://doi.org/10.5772/intechopen.85253
  132. Chu Kion Yao, Natural Hoi Sing Chu, Victoria Ping Yi Tan. Breath Hydrogen Testing in East and Southeast Asia. 2018;52:185
    https://doi.org/10.1097/MCG.0000000000000943
  133. Prashant Singh, Sarah Duehren, Jesse Katon, Vikram Rangan, Sarah Ballou, Raxitkumar Patel, Johanna Iturrino, Anthony Lembo, Judy Nee. Breath Methane Does Not Correlate With Constipation Severity or Bloating in Patients With Constipation. 2020;54:365
    https://doi.org/10.1097/MCG.0000000000001239
  134. Anna Szabó, Karl Unterkofler, Pawel Mochalski, Martin Jandacka, Vera Ruzsanyi, Gábor Szabó, Árpád Mohácsi, Susanne Teschl, Gerald Teschl, Julian King. Modeling of breath methane concentration profiles during exercise on an ergometer. J. Breath Res. 2016;10:017105
    https://doi.org/10.1088/1752-7155/10/1/017105
  135. Irene Sarosiek, Mohammad Bashashati, Alicia Alvarez, Mark Hall, Nagasri Shankar, Yvette Gomez, Richard W. McCallum, Jerzy Sarosiek. Lubiprostone Accelerates Intestinal Transit and Alleviates Small Intestinal Bacterial Overgrowth in Patients With Chronic Constipation. The American Journal of the Medical Sciences 2016;352:231
    https://doi.org/10.1016/j.amjms.2016.05.012
  136. Sandra Y. Wotzka, Markus Kreuzer, Lisa Maier, Mirjam Zünd, Markus Schlumberger, Bidong Nguyen, Mark Fox, Daniel Pohl, Henriette Heinrich, Gerhard Rogler, Luc Biedermann, Michael Scharl, Shinichi Sunagawa, Wolf-Dietrich Hardt, Benjamin Misselwitz, Christopher Staley. Microbiota stability in healthy individuals after single-dose lactulose challenge—A randomized controlled study. PLoS ONE 2018;13:e0206214
    https://doi.org/10.1371/journal.pone.0206214
  137. Mithun Pal, Manik Pradhan. Progress in Optomechatronics. 2018.
    https://doi.org/10.1007/978-981-15-6467-3_11