Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Cited by CrossRef (266)

  1. Jenny Beebe, Sophia Josephraj, Chao J. Wang, Jacob Danielson, Qingbin Cui, Caoqinglong Huang, Lincoln Barlow, Ryan H. Zhang, Taolan Zhang, Harikrishna Nakshatri, Zizheng Dong, Xiaohong Li, Jing-Yuan Liu, Jian-Ting Zhang. Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase. J. Med. Chem. 2022;65:13681
    https://doi.org/10.1021/acs.jmedchem.2c00642
  2. James S. Martin, Claire J. MacKenzie, Daniel Fletcher, Ian H. Gilbert. Characterising covalent warhead reactivity. Bioorganic & Medicinal Chemistry 2019;27:2066
    https://doi.org/10.1016/j.bmc.2019.04.002
  3. Andy Liu, Bellal Jubran, Emeka K. Enwere, Megan Hansen, Nicole E. Burma, Yasmin Nasser. Encyclopedia of Gastroenterology. 2019.
    https://doi.org/10.1016/B978-0-12-801238-3.65617-9
  4. Yang Li, Bo-xue Ren, Hong-mei Li, Tao Lu, Rong Fu, Zhao-qiu Wu. Omeprazole suppresses aggressive cancer growth and metastasis in mice through promoting Snail degradation. Acta Pharmacol Sin 2022;43:1816
    https://doi.org/10.1038/s41401-021-00787-1
  5. Dongyang Liu, Hong Yang, Ji Jiang, Péter Nagy, Kai Shen, Jiaming Qian, Pei Hu. Pharmacokinetic and Pharmacodynamic Modeling Analysis of Intravenous Esomeprazole in Healthy Volunteers. The Journal of Clinical Pharmacology 2016;56:816
    https://doi.org/10.1002/jcph.733
  6. PHANEENDRA KURAPATI, SANTHIVARDHAN CHINNI. DEVELOPMENT AND OPTIMIZATION OF RABEPRAZOLE CHRONO-MODULATED DRUG DELIVERY SYSTEMS. Int J App Pharm 2024:332
    https://doi.org/10.22159/ijap.2024v16i3.50189
  7. Yang Won Min, Yeong Chan Lee, Kyunga Kim, Seungho Ryu, Kyoung Sub Hong, Han Ho Jeon, Yong Sung Kim, Jong Heon Park, Hee Jung Son, Poong-Lyul Rhee. Proton pump inhibitor use is associated with hip fracture development: a nationwide population-based cohort study . Korean J Intern Med 2020;35:1084
    https://doi.org/10.3904/kjim.2018.331
  8. Mehmet Gul, Serkan Dundar, Alihan Bozoglan, Erhan Cahit Ozcan, Samet Tekin, Tuba Talo Yildirim, Necmettin Karasu, Muhammet Bahattin Bingul. Evaluation of the effects of the systemic proton pump inhibitor-omeprazole on periimplant bone regeneration and osseointegration: An experimental study. Journal of Oral Biology and Craniofacial Research 2022;12:381
    https://doi.org/10.1016/j.jobcr.2022.04.006
  9. Khadija Rouaz-El Hajoui, Helena Herrada-Manchón, David Rodríguez-González, Manuel Alejandro Fernández, Enrique Aguilar, Marc Suñé-Pou, Anna Nardi-Ricart, Pilar Pérez-Lozano, Encarna García-Montoya. Pellets and gummies: Seeking a 3D printed gastro-resistant omeprazole dosage for paediatric administration. International Journal of Pharmaceutics 2023;643:123289
    https://doi.org/10.1016/j.ijpharm.2023.123289
  10. Naina Mohamed Pakkir Maideen. Adverse Effects Associated with Long-Term Use of Proton Pump Inhibitors. Chonnam Med J 2023;59:115
    https://doi.org/10.4068/cmj.2023.59.2.115
  11. Dong Han Yeom, Yong Sung Kim. History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs. Korean J Helicobacter Up Gastrointest Res 2023;23:159
    https://doi.org/10.7704/kjhugr.2023.0040
  12. Sarang Jang, Hyo Geun Choi, Mi Jung Kwon, Ji Hee Kim, Joo-Hee Kim, Yoonjoong Kim, So Young Kim. Association between the Use of Proton Pump Inhibitors and Cardiovascular Diseases: A Nested Case-Control Study Using a National Health Screening Cohort. Biomedicines 2024;12:170
    https://doi.org/10.3390/biomedicines12010170
  13. Anna Papazoglou, Muhammad I. Arshaad, Christina Henseler, Johanna Daubner, Karl Broich, Britta Haenisch, Marco Weiergräber. The Janus-like Association between Proton Pump Inhibitors and Dementia. CAR 2021;18:453
    https://doi.org/10.2174/1567205018666210929144740
  14. Avik Ray, Swati Sharma, Balakrishnan Sadasivam. The Potential Therapeutic Role of Proton Pump Inhibitors in COVID-19: Hypotheses Based on Existing Evidences. Drug Res (Stuttg) 2020;70:484
    https://doi.org/10.1055/a-1236-3041
  15. Ranran Jia, Fan Zhang, Ni Wu, Wen Xu, Huitao Gao, Bo Liu, Hongyun Wang. Accelerating Development of Benziamidazole-Class Proton Pump Inhibitors: A Mechanism-Based PK/PD Model to Optimize Study Design with Ilaprazole as a Case Drug. Pharmaceutics 2021;13:392
    https://doi.org/10.3390/pharmaceutics13030392
  16. Jin-Young Min, Christopher J. Ocampo, Whitney W. Stevens, Caroline P.E. Price, Christopher F. Thompson, Tetsuya Homma, Julia H. Huang, James E. Norton, Lydia A. Suh, Kathryn L. Pothoven, David B. Conley, Kevin C. Welch, Stephanie Shintani-Smith, Anju T. Peters, Leslie C. Grammer, Kathleen E. Harris, Kathryn E. Hulse, Atsushi Kato, Nikolai N. Modyanov, Robert C. Kern, Robert P. Schleimer, Bruce K. Tan. Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric H,K-ATPase. Journal of Allergy and Clinical Immunology 2017;139:130
    https://doi.org/10.1016/j.jaci.2016.07.020
  17. Loren Laine, Prateek Sharma, Darcy J. Mulford, Barbara Hunt, Eckhard Leifke, Neila Smith, Colin W. Howden. Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects. Am J Gastroenterol 2022;117:1158
    https://doi.org/10.14309/ajg.0000000000001735
  18. Kunfeng Yan, Xiaorong Dai, Zhenxing Li, Weiwei Rong, Lei Chen, Xinxin Diao. Clinical Study on the Eradication of Helicobacter pylori by Vonoprazan Combined with Amoxicillin for 10‐Day Dual Therapy. Clinical Pharm in Drug Dev 2024
    https://doi.org/10.1002/cpdd.1357
  19. Craig M. Lilly, Mohammad Aljawadi, Omar Badawi, Ebere Onukwugha, Sarah E. Tom, Laurence S. Magder, Ilene Harris. Comparative Effectiveness of Proton Pump Inhibitors vs Histamine Type 2 Receptor Blockers for Preventing Clinically Important Gastrointestinal Bleeding During Intensive Care. Chest 2018;154:557
    https://doi.org/10.1016/j.chest.2018.05.015
  20. Akiko Shiotani, Ryo Katsumata, Kyousuke  Gouda, Shinya Fukushima, Rui Nakato, Takahisa Murao, Manabu Ishii, Minoru Fujita, Hiroshi Matsumoto, Takashi Sakakibara. Hypergastrinemia in Long-Term Use of Proton Pump Inhibitors. Digestion 2018;97:154
    https://doi.org/10.1159/000484688
  21. Hariharan Sivaraman, Shi Yin Er, Yeu Khai Choong, Edem Gavor, J. Sivaraman. Structural Basis of SARS-CoV-2– and SARS-CoV–Receptor Binding and Small-Molecule Blockers as Potential Therapeutics. Annu. Rev. Pharmacol. Toxicol. 2021;61:465
    https://doi.org/10.1146/annurev-pharmtox-061220-093932
  22. Tae Jin Lee, Dohyun Kim, Jae Cheon Kim, Si Won Ro, Dong Hee Na. Formulation development and pharmacokinetic evaluation of enteric-coated dexrabeprazole tablets. J. Pharm. Investig. 2023;53:323
    https://doi.org/10.1007/s40005-022-00602-x
  23. Yutong Li, Nan Li, Anouck Girard, Ilya Kolmanovsky. Scheduling Dosage of Proton Pump Inhibitors Using Constrained Optimization With Gastric Acid Secretion Model. IFAC-PapersOnLine 2023;56:6465
    https://doi.org/10.1016/j.ifacol.2023.10.860
  24. Sung-Hwa Sohn, Nayoung Kim, Hyun Jin Jo, Jaeyeon Kim, Ji Hyun Park, Ryoung Hee Nam, Yeong-Jae Seok, Yeon-Ran Kim, Dong Ho Lee. Analysis of Gastric Body Microbiota by Pyrosequencing: Possible Role of Bacteria Other ThanHelicobacter pyloriin the Gastric Carcinogenesis. J Cancer Prev 2017;22:115
    https://doi.org/10.15430/JCP.2017.22.2.115
  25. V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, O. A. Storonova, O. V. Zayratyants, O. B. Dronova, Yu. A. Kucheryavyy, S. S. Pirogov, R. G. Sayfutdinov, Yu. P. Uspenskiy, A. A. Sheptulin, D. N. Andreev, D. E. Rumyantseva. Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease. Rossijskij žurnal gastroènterologii, gepatologii, koloproktologii 2020;30:70
    https://doi.org/10.22416/1382-4376-2020-30-4-70-97
  26. Valentina Shakhnovich, P. Brian Smith, Jeffrey T. Guptill, Laura P. James, David N. Collier, Huali Wu, Chad E. Livingston, Jian Zhao, Gregory L. Kearns, Daniel K. Benjamin, Katherine Y. Berezny, P. Michael Cohen Wolkowiez, Matthew M. Laughon, Ian M. Paul, Michael J. Smith, John van den Anker, Kelly Wade, David Siegel, Perdita Taylor-Zapata, Anne Zajicek, Zhaoxia Ren, Ekaterini Tsilou, Alice Pagan, Ravinder Anand, Traci Clemons, Gina Simone, Lee Howard, Jaylene Weigel, Nancy Darden Saad. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures. The Journal of Pediatrics 2018;193:102
    https://doi.org/10.1016/j.jpeds.2017.10.011
  27. Yuli Guzman-Prado, Roberto Vita, Ondrej Samson. Concomitant Use of Levothyroxine and Proton Pump Inhibitors in Patients with Primary Hypothyroidism: a Systematic Review. J GEN INTERN MED 2021;36:1726
    https://doi.org/10.1007/s11606-020-06403-y
  28. Mustafa Abdul‐Hussein, Janice Freeman, Donald Castell. Concomitant Administration of a Histamine2 Receptor Antagonist and Proton Pump Inhibitor Enhances Gastric Acid Suppression. Pharmacotherapy 2015;35:1124
    https://doi.org/10.1002/phar.1665
  29. Yi Song, Fengna Dou, Zhe Zhou, Ningmin Yang, Jing Zhong, Jie Pan, Qiqi Liu, Jianzhong Zhang, Shengqi Wang. Microarray-Based Detection and Clinical Evaluation for Helicobacter pylori Resistance to Clarithromycin or Levofloxacin and the Genotype of CYP2C19 in 1083 Patients. BioMed Research International 2018;2018:1
    https://doi.org/10.1155/2018/2684836
  30. Clyde A. Smith, Afshin Ebrahimpour, Lyudmila Novikova, Dominic Farina, Aaron O. Bailey, William K. Russell, Antrix Jain, Alexander B. Saltzman, Anna Malovannaya, B.V. Venkataram Prasad, Liya Hu, Yohannes T. Ghebre. Esomeprazole covalently interacts with the cardiovascular enzyme dimethylarginine dimethylaminohydrolase: Insights into the cardiovascular risk of proton pump inhibitors. Biochimica et Biophysica Acta (BBA) - General Subjects 2022;1866:130149
    https://doi.org/10.1016/j.bbagen.2022.130149
  31. Johan Gabrielsson, Stephan Hjorth. Early Drug Development. 2022.
    https://doi.org/10.1002/9783527801756.ch14
  32. Ankit Namdev, Dharmendra Jain. Floating Drug Delivery Systems: An Emerging Trend for the Treatment of Peptic Ulcer. CDD 2019;16:874
    https://doi.org/10.2174/1567201816666191018163519
  33. Hsun Yang, Shiun-Yang Juang, Kuan-Fu Liao. Proton pump inhibitors use and risk of chronic kidney disease in diabetic patients. Diabetes Research and Clinical Practice 2019;147:67
    https://doi.org/10.1016/j.diabres.2018.11.019
  34. Mahdieh Darroudi, Ghodsi Mohammadi Ziarani, Shahriyar Bahar, Jahan B. Ghasemi, Alireza Badiei. Lansoprazole-Based Colorimetric Chemosensor for Efficient Binding and Sensing of Carbonate Ion: Spectroscopy and DFT Studies. Front. Chem. 2021;8
    https://doi.org/10.3389/fchem.2020.626472
  35. Laurent Soulère, Thibaut Barbier, Yves Queneau. Docking-based virtual screening studies aiming at the covalent inhibition of SARS-CoV-2 MPro by targeting the cysteine 145. Computational Biology and Chemistry 2021;92:107463
    https://doi.org/10.1016/j.compbiolchem.2021.107463
  36. Holmfridur Helgadottir, Einar S. Bjornsson. Problems Associated with Deprescribing of Proton Pump Inhibitors. IJMS 2019;20:5469
    https://doi.org/10.3390/ijms20215469
  37. Ciro Celsa, Calogero Cammà. Editorial: proton pump inhibitor use in cirrhosis—a piece of the puzzle. Aliment Pharmacol Ther 2021;53:663
    https://doi.org/10.1111/apt.16250
  38. Yugo Hamada, Kenji Ikemura, Takuya Iwamoto, Masahiro Okuda. Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers. Pharmacology 2018;101:176
    https://doi.org/10.1159/000485920
  39. Dragos Apostu, Ondine Lucaciu, Gheorghe Dan Osvald Lucaciu, Bogdan Crisan, Liana Crisan, Mihaela Baciut, Florin Onisor, Grigore Baciut, Radu Septimiu Câmpian, Simion Bran. Systemic drugs that influence titanium implant osseointegration. Drug Metabolism Reviews 2017;49:92
    https://doi.org/10.1080/03602532.2016.1277737
  40. Timothy P. Shiraev, Andrew Bullen. Proton Pump Inhibitors and Cardiovascular Events: A Systematic Review. Heart, Lung and Circulation 2018;27:443
    https://doi.org/10.1016/j.hlc.2017.10.020
  41. Jessica Escoffier, Bastien Arnaud, Mayis Kaba, Jean Pascal Hograindleur, Emilie Le Blévec, Guillaume Martinez, Isabelle Stévant, Pierre F. Ray, Christophe Arnoult, Serge Nef. Pantoprazole, a proton‐pump inhibitor, impairs human sperm motility and capacitation in vitro. Andrology 2020;8:1795
    https://doi.org/10.1111/andr.12855
  42. Carol M. Antequera, Kimberly Orleck, Rinu Jacob, Amy Kenneally, Wendy L. Wright. Potassium-competitive acid blockers: rethinking acid suppression for gastroesophageal reflux disease and Helicobacter pylori . Postgraduate Medicine 2024;136:131
    https://doi.org/10.1080/00325481.2024.2320081
  43. Xiaoxiao Yang, Yueyue Li, Yiyuan Sun, Mingming Zhang, Chuanguo Guo, Iqtida Ahmed Mirza, Yan-Qing Li. Vonoprazan: A Novel and Potent Alternative in the Treatment of Acid-Related Diseases. Dig Dis Sci 2018;63:302
    https://doi.org/10.1007/s10620-017-4866-6
  44. Alexandra Tiţa, Roxana-Marcela Criseru, Ana-Maria-Andreea Ioan, Selda Ali, Roxana Silvia Bumbăcea. Hypersensitivity reactions induced by proton pump inhibitors: diagnostic and management strategies. Alergologia 2023;3:122
    https://doi.org/10.26416/Aler.7.3.2023.8790
  45. Carine Franco Morschel, Denise Mafra, José Carlos Carraro Eduardo. The relationship between proton pump inhibitors and renal disease. J. Bras. Nefrol. 2018;40:301
    https://doi.org/10.1590/2175-8239-jbn-2018-0021
  46. Vincent H Ha, Margaret Ngo, Michael P Chu, Sunita Ghosh, Michael B Sawyer, Carole R Chambers. Does gastric acid suppression affect sunitinib efficacy in patients with advanced or metastatic renal cell cancer?. J Oncol Pharm Pract 2015;21:194
    https://doi.org/10.1177/1078155214527145
  47. Mohamed S. AbdElhalim, Ahmed S. Kenawy, Heba H. El Demellawy, Amany A. Azouz, Sarah S. Alghanem, Torki Al-Otaibi, Osama Gheith, Mohamed Abd ElMonem, Mohammed K. Afifi, Raghda R. S. Hussein. The impact of omeprazole on mycophenolate pharmacokinetics in kidney transplant recipients. Kidney Res Clin Pract 2020;39:479
    https://doi.org/10.23876/j.krcp.20.059
  48. Mitsuhiro Tachibana, Tomohiko Hanaoka, Shinya Watanabe, Masahiro Matsushita, Tadahiro Isono, Yutaka Tsutsumi. Colitis nucleomigrans: The third type of microscopic colitis (part 1). Pathology International 2020;70:752
    https://doi.org/10.1111/pin.12996
  49. Mohammed N. Abed, Fawaz A. Alassaf, Mahmood H.M. Jasim, Mohanad Alfahad, Mohannad E. Qazzaz. Comparison of Antioxidant Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole. Pharmacology 2020;105:645
    https://doi.org/10.1159/000506232
  50. Anthony J. Doman, Sara Tommasi, Michael V. Perkins, Ross A. McKinnon, Arduino A. Mangoni, Pramod C. Nair. Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulating the nitric oxide pathway. Bioorganic & Medicinal Chemistry 2022;72:116970
    https://doi.org/10.1016/j.bmc.2022.116970
  51. Yingting Wu, Jiaqi Xin, Xinyu Li, Ting Yang, Yi Liu, Yongsheng Zhao, Wen Xie, Mengxi Jiang. Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition. Acta Pharmaceutica Sinica B 2024;14:1711
    https://doi.org/10.1016/j.apsb.2024.01.001
  52. Shringi Sharma, Xavier Pepin, Jean Cheung, Lianqing Zheng, Hua Wei, Danielle Townsley, David Han, Michal Majewski, Joseph A. Ware, James Mann, Veerendra Munugalavadla, Louise Sheridan, Priti Patel, Ashok Gupta, Helen Tomkinson. Bioavailability of acalabrutinib suspension delivered via nasogastric tube in the presence or absence of a proton pump inhibitor in healthy subjects. Brit J Clinical Pharma 2022;88:4573
    https://doi.org/10.1111/bcp.15362
  53. Adila Salih ElObeid, Adil Haseeb. Treating ENT symptoms and diseases induced by extraesophageal acidity using plant extracted melanin. Medical Hypotheses 2020;144:110126
    https://doi.org/10.1016/j.mehy.2020.110126
  54. Mihirkumar P Parmar, Safa Kaleem, Periyaiyadever Samuganathan, Lyluma Ishfaq, Tejawi Anne, Yashaswi Patel, Sashank Bollu, Roopeessh Vempati. Impact of Proton Pump Inhibitors on Kidney Function and Chronic Kidney Disease Progression: A Systematic Review. 2023
    https://doi.org/10.7759/cureus.49883
  55. S. Šutalo, M. Ruetten, S. Hartnack, C.E. Reusch, P. H. Kook. The Effect of Orally Administered Ranitidine and Once‐Daily or Twice‐Daily Orally Administered Omeprazole on Intragastric pH in Cats. Veterinary Internal Medicne 2015;29:840
    https://doi.org/10.1111/jvim.12580
  56. Ryoko Toda, Tomoharu Miyagawa, Yuka Masuda, Yusuke Hoshino, Kazuyoshi Yoshii, Masamichi Hirayama, Minaka Shibuya, Yoshihiro Kawabata. Mass balance and metabolism of Z-215, a novel proton pump inhibitor, in healthy volunteers. Xenobiotica 2018;48:1006
    https://doi.org/10.1080/00498254.2017.1390625
  57. Florence Carrouel, Mikhail Dziadzko, Charles Grégoire, Michel Galinski, Claude Dussart, Virginie-Eve Lvovschi. Relevance of early management by proton-pump inhibitor in acute upper gastro-intestinal tract disorder: A scoping review. Biomedicine & Pharmacotherapy 2023;167:115523
    https://doi.org/10.1016/j.biopha.2023.115523
  58. Cheol Min Shin. Alternations of Gastric Microbiota with Mucosal Atrophy and Intestinal Metaplasia. Korean J Helicobacter Up Gastrointest Res 2020;20:187
    https://doi.org/10.7704/kjhugr.2020.0037
  59. Hashem Ahmadizadegan, Mahdi Ranjbar, Sheida Esmaielzadeh. Synthesis and characterization of green membranes polyimide/titania bionanocomposites containing amino acid and benzimidazole moieties for gas transport properties. Polymer Engineering & Sci 2018;58:1666
    https://doi.org/10.1002/pen.24757
  60. J.M. Remes-Troche, F.D. García García, G. Rojas-Loureiro, X. Rivera-Gutiérrez, J. Reyes-Huerta, M. Amieva-Balmori. Efecto sobre el pH intragástrico de 20 mg de levopantoprazol versus 40 mg de pantoprazol racémico durante los primeros 7 días de tratamiento en pacientes con enfermedad por reflujo gastroesofágico. Revista de Gastroenterología de México 2020;85:48
    https://doi.org/10.1016/j.rgmx.2019.02.006
  61. Annamaria Tonazzi, Ivano Eberini, Cesare Indiveri, Gabriele Vincenzo Gnoni. Molecular Mechanism of Inhibition of the Mitochondrial Carnitine/Acylcarnitine Transporter by Omeprazole Revealed by Proteoliposome Assay, Mutagenesis and Bioinformatics. PLoS ONE 2013;8:e82286
    https://doi.org/10.1371/journal.pone.0082286
  62. Tatjana Bosnjak, Rigmor Solberg, Paya Diana Hemati, Abbas Jafari, Moustapha Kassem, Harald Thidemann Johansen. Lansoprazole inhibits the cysteine protease legumain by binding to the active site. Basic Clin Pharma Tox 2019;125:89
    https://doi.org/10.1111/bcpt.13230
  63. Farwa Jafri, Zachary L. Taylor, Daniel Gonzalez, Valentina Shakhnovich. Effects of obesity on the pharmacology of proton pump inhibitors: current understanding and future implications for patient care and research. Expert Opinion on Drug Metabolism & Toxicology 2023;19:1
    https://doi.org/10.1080/17425255.2023.2178897
  64. Yoon Jin Choi, Nayoung Kim, In-Jin Jang, Joo-Youn Cho, Ryoung Hee Nam, Ji Hyun Park, Hyun Jin Jo, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Hyun Chae Jung. Pantoprazole Does Not Reduce the Antiplatelet Effect of Clopidogrel: A Randomized Controlled Trial in Korea. Gut and Liver 2017;11:504
    https://doi.org/10.5009/gnl16352
  65. Md. Saddam Hussain, Tanoy Mazumder. Long-term use of proton pump inhibitors adversely affects minerals and vitamin metabolism, bone turnover, bone mass, and bone strength. 2022;33:567
    https://doi.org/10.1515/jbcpp-2021-0203
  66. Jarin Tasnim, Najihah Mohd Hashim, Heh Choon Han. A comprehensive review on potential drug–drug interactions of proton pump inhibitors with antidiabetic drugs metformin and DPP‐4 inhibitors. Cell Biochemistry & Function 2024;42
    https://doi.org/10.1002/cbf.3967
  67. Hsiu-Chen Lin, Yu-Ting Hsiao, Hsiu-Li Lin, Yow-Shieng Uang, Hui-Wen Cheng, Ying Wang, Li-Hsuan Wang. The use of proton pump inhibitors decreases the risk of diabetes mellitus in patients with upper gastrointestinal disease. 2016;95:e4195
    https://doi.org/10.1097/MD.0000000000004195
  68. Allah Nazar Atif, Atousa Hatefi, Asadullah Arven, Alireza Foroumadi, Sara Kadkhodaei, Alireza Sadjadi, Farideh Siavoshi. Consumption of non-antibacterial drugs may have negative impact on Helicobacter pylori colonization in the stomach. Heliyon 2024;10:e27327
    https://doi.org/10.1016/j.heliyon.2024.e27327
  69. BYUNG KIL CHOO, SEONG-SOO ROH. Berberine protects against esophageal mucosal damage in reflux esophagitis by suppressing proinflammatory cytokines. 2013;6:663
    https://doi.org/10.3892/etm.2013.1202
  70. Tanzila Arshad, Khalid Mohammed Khan, Najma Rasool, Uzma Salar, Shafqat Hussain, Humna Asghar, Mohammed Ashraf, Abdul Wadood, Muhammad Riaz, Shahnaz Perveen, Muhammad Taha, Nor Hadiani Ismail. 5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of α -glucosidase and urease enzymes. Bioorganic Chemistry 2017;72:21
    https://doi.org/10.1016/j.bioorg.2017.03.007
  71. M. Srinivas, S. Satyaveni, B. Ram. Synthesis and Anticancer Activity of 1,2,4-Oxadiazol Linked Benzimidazole Derivatives. Russ J Gen Chem 2018;88:2653
    https://doi.org/10.1134/S1070363218120289
  72. Sara Granja, Diana Tavares-Valente, Odília Queirós, Fátima Baltazar. Value of pH regulators in the diagnosis, prognosis and treatment of cancer. Seminars in Cancer Biology 2017;43:17
    https://doi.org/10.1016/j.semcancer.2016.12.003
  73. Agastya Patel, Piotr Spychalski, Magdalena Antoszewska, Jaroslaw Regula, Jarek Kobiela. Proton pump inhibitors and colorectal cancer: A systematic review. WJG 2021;27:7716
    https://doi.org/10.3748/wjg.v27.i44.7716
  74. Taek Kwan Kwon, Ji-Hyun Kang, Sang-Beom Na, Jae Ho Kim, Yong-Il Kim, Dong-Wook Kim, Chun-Woong Park. Novel Esomeprazole Magnesium-Loaded Dual-Release Mini-Tablet Polycap: Formulation, Optimization, Characterization, and In Vivo Evaluation in Beagle Dogs. Pharmaceutics 2022;14:1411
    https://doi.org/10.3390/pharmaceutics14071411
  75. Jung Sunwoo, Sang Chun Ji, Jaeseong Oh, Mu Seong Ban, Ji Yeon Nam, Bongtae Kim, Geun Seog Song, Kyung‐Sang Yu, In‐Jin Jang, SeungHwan Lee. Pharmacodynamics of tegoprazan and revaprazan after single and multiple oral doses in healthy subjects. Aliment Pharmacol Ther 2020;52:1640
    https://doi.org/10.1111/apt.16121
  76. Ran Li, Xiaoyun Chai, Xiaoyan Cui, Yuanying Jiang, Dazhi Zhang, Ting Wang. A fluorescence resonance energy transfer based pH probe for visualizing acidification in fungal cells. Sensors and Actuators B: Chemical 2018;274:533
    https://doi.org/10.1016/j.snb.2018.07.134
  77. J. P. Moraes-Filho, M. Pedroso, E. M. M. Quigley. Randomised clinical trial: daily pantoprazole magnesium 40 mg vs. esomeprazole 40 mg for gastro-oesophageal reflux disease, assessed by endoscopy and symptoms. Aliment Pharmacol Ther 2014;39:47
    https://doi.org/10.1111/apt.12540
  78. Susan M. Watanabe, Lorna S. Ehrlich, Madeleine Strickland, Xiaofan Li, Veronica Soloveva, Arthur J. Goff, Charles B. Stauft, Sumita Bhaduri-McIntosh, Nico Tjandra, Carol Carter. Selective Targeting of Virus Replication by Proton Pump Inhibitors. Sci Rep 2020;10
    https://doi.org/10.1038/s41598-020-60544-y
  79. Óskar Ö. Hálfdánarson, Katja Fall, Margret H. Ogmundsdottir, Sigrún H. Lund, Eiríkur Steingrímsson, Helga M. Ogmundsdottir, Helga Zoega. Proton pump inhibitor use and risk of breast cancer, prostate cancer, and malignant melanoma: An Icelandic population‐based case‐control study. Pharmacoepidemiology and Drug 2019;28:471
    https://doi.org/10.1002/pds.4702
  80. Yvonne Y. Lau, Wen Gu, Tiffany Lin, Kalyanee Viraswami-Appanna, Can Cai, Jeffrey W. Scott, Michael Shi. Assessment of drug–drug interaction potential between ceritinib and proton pump inhibitors in healthy subjects and in patients with ALK-positive non-small cell lung cancer. Cancer Chemother Pharmacol 2017;79:1119
    https://doi.org/10.1007/s00280-017-3308-7
  81. Prakash Bhaskar, Vasantha Kumar, Suresha Kumara Tholappanavara Hanumanthappa, Sowmya Haliwana Banakara Vijaykumar. 2-(3,4-Dimethoxyphenyl)-N-(4-methoxyphenyl)-1-propyl-1H-benzo[d]imidazole-5-carboxamide. Molbank 2019;2019:M1079
    https://doi.org/10.3390/M1079
  82. Caroline Dale, Rohan Takhar, Michail Katsoulis, Valerie Kuan Po Ai, Sheng-Chia Chung, Rui Providencia, John P. Overington, Reecha Sofat. Investigating the Potential Anti-Viral Effects of Proton Pump Inhibitors on Influenza: Intention-to-Treat Trial Emulation Using Electronic Health Records. SSRN Journal 2022
    https://doi.org/10.2139/ssrn.4103143
  83. . Drug Disposition and Pharmacokinetics. 2022.
    https://doi.org/10.1002/9781119589181.ch15
  84. E. Pradeepa, Y. Arthoba Nayaka. Cerium oxide nanoparticles via gel-combustion for electrochemical investigation of pantoprazole in the presence of epinephrine. J Mater Sci: Mater Electron 2022;33:18374
    https://doi.org/10.1007/s10854-022-08692-x
  85. Yingxi Chen, Bette Liu, Kathryn Glass, Wei Du, Emily Banks, Martyn Kirk, John Green. Use of Proton Pump Inhibitors and the Risk of Hospitalization for Infectious Gastroenteritis. PLoS ONE 2016;11:e0168618
    https://doi.org/10.1371/journal.pone.0168618
  86. Caroline Race, Joanna Chowdry, Jean M. Russell, Bernard M. Corfe, Stuart A. Riley. Studies of salivary pepsin in patients with gastro‐oesophageal reflux disease. Aliment Pharmacol Ther 2019;49:1173
    https://doi.org/10.1111/apt.15138
  87. Davide Cucchi, Alessandra Menon, Francesca Maria Feroldi, Linda Boerci, Pietro Simone Randelli. The presence of gastroesophageal reflux disease increases the risk of developing postoperative shoulder stiffness after arthroscopic rotator cuff repair. Journal of Shoulder and Elbow Surgery 2020;29:2505
    https://doi.org/10.1016/j.jse.2020.07.002
  88. Helena Emery, Tariq M. Butt, Christopher J. Coates. Nutraceutical intervention protects against bacterial and chemical-induced gastrotoxicity in a non-mammalian model, Galleria mellonella. Food and Chemical Toxicology 2021;154:112354
    https://doi.org/10.1016/j.fct.2021.112354
  89. Young Kwang Shim, Nayoung Kim. The Effect of H2Receptor Antagonist in Acid Inhibition and Its Clinical Efficacy. Korean J Gastroenterol 2017;70:4
    https://doi.org/10.4166/kjg.2017.70.1.4
  90. Flávia Almeida Santos, Vietla Satyanarayana Rao. Sistema Digestório: Integração Básico-Clínica. 2017.
    https://doi.org/10.5151/9788580391893-23
  91. K. Renuka Prasad, Priyanka Chettri, N. A. Rajesh, A. Rathinaswamy, R. Padmanaban, T. M. Vijayakumar. Assessment of the risk of acute kidney injury associated with the use of pantoprazole and esomeprazole. Drugs Ther Perspect 2018;34:223
    https://doi.org/10.1007/s40267-018-0503-5
  92. J.M. Remes-Troche, F.D. García García, G. Rojas-Loureiro, X. Rivera-Gutiérrez, J. Reyes-Huerta, M. Amieva-Balmori. Intragastric pH effect of 20 mg of levo-pantoprazole versus 40 mg of racemic pantoprazole the first seven days of treatment in patients with gastroesophageal reflux disease. Revista de Gastroenterología de México (English Edition) 2020;85:48
    https://doi.org/10.1016/j.rgmxen.2019.02.016
  93. Pietro Enea Lazzerini, Alessandra Cartocci, Yongxia Sarah Qu, Simona Saponara, Simone Furini, Fabio Fusi, Frank Fabris, Alessandra Gamberucci, Nabil El-Sherif, Gabriele Cevenini, Francesco Pettini, Franco Laghi-Pasini, Maurizio Acampa, Iacopo Bertolozzi, Pier Leopoldo Capecchi, Deana Lazaro, Mohamed Boutjdir. Proton Pump Inhibitors Directly Block hERG-Potassium Channel and Independently Increase the Risk of QTc Prolongation in a Large Cohort of US Veterans. Circ: Arrhythmia and Electrophysiology 2021;14
    https://doi.org/10.1161/CIRCEP.121.010042
  94. Artem Minalyan, Lilit Gabrielyan, David Scott, Jonathan Jacobs, Joseph R. Pisegna. The Gastric and Intestinal Microbiome: Role of Proton Pump Inhibitors. Curr Gastroenterol Rep 2017;19
    https://doi.org/10.1007/s11894-017-0577-6
  95. Uriel Gomez-Ramirez, Pedro Valencia-Mayoral, Sandra Mendoza-Elizalde, Juan Rafael Murillo-Eliosa, Fortino Solórzano Santos, Araceli Contreras-Rodríguez, Gerardo Zúñiga, Pamela Aguilar-Rodea, Verónica Leticia Jiménez-Rojas, Juan Carlos Vigueras Galindo, Marcela Salazar-García, Norma Velázquez-Guadarrama. Role of Helicobacter pylori and Other Environmental Factors in the Development of Gastric Dysbiosis. Pathogens 2021;10:1203
    https://doi.org/10.3390/pathogens10091203
  96. Lisanne M. M. Gommers, Joost G. J. Hoenderop, Jeroen H. F. de Baaij. Mechanisms of proton pump inhibitor‐induced hypomagnesemia. Acta Physiologica 2022;235
    https://doi.org/10.1111/apha.13846
  97. Antonio Pirodda, Maria Chiara Raimondi, Arrigo Francesco Giuseppe Cicero, Martina Rosticci, Elisa Rebecca Rinaldi, Lara Bellacosa, Vincenzo Stanghellini, Claudio Borghi. Tinnitus in patients on therapy with proton pump inhibitors (PPI) and in PPI non-users. Hearing, Balance and Communication 2014;12:84
    https://doi.org/10.3109/21695717.2014.902554
  98. Khaled A. Shibany, Stefanie L. Pratt, Mohammed Aldurdunji, Sabine Totemeyer, Stuart W. Paine. Prediction of pharmacokinetic clearance and potential Drug-Drug interactions for omeprazole in the horse using in vitro systems. Xenobiotica 2020;50:1220
    https://doi.org/10.1080/00498254.2020.1764131
  99. Wei Li, Han Yao, Chenxi Gu, Yuanyuan Ren, Jiadai Liu, Baijiao An, Wenhao Hu, Xingshu Li, Albert S.C. Chan. Discovery of a potent EGFR and ALK dual mutation inhibitor containing N-(3-((4-((2-(cyclopropylsulfinyl)phenyl)amino)pyrimidin-2-yl)amino) phenyl)acrylamide scaffold. Bioorganic Chemistry 2022;129:106188
    https://doi.org/10.1016/j.bioorg.2022.106188
  100. Roman A. Sukhovershin, John P. Cooke. How May Proton Pump Inhibitors Impair Cardiovascular Health?. Am J Cardiovasc Drugs 2016;16:153
    https://doi.org/10.1007/s40256-016-0160-9
  101. Mohammed Albatany, Valeriy G. Ostapchenko, Susan Meakin, Robert Bartha. Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms. J Neurooncol 2019;144:453
    https://doi.org/10.1007/s11060-019-03251-7
  102. Joo Hyun Oh, Danbee Kang, Wonseok Kang, Eliseo Guallar, Juhee Cho, Yang Won Min. Proton Pump Inhibitor Use Increases Pyogenic Liver Abscess Risk: A Nationwide Cohort Study. J Neurogastroenterol Motil 2021;27:555
    https://doi.org/10.5056/jnm20221
  103. Agnieszka Wiesner, Małgorzata Zwolińska-Wcisło, Paweł Paśko. Effect of Food and Dosing Regimen on Safety and Efficacy of Proton Pump Inhibitors Therapy—A Literature Review. IJERPH 2021;18:3527
    https://doi.org/10.3390/ijerph18073527
  104. Endre Csiki, Hanna Szabó, Lilla Hanák, Zsolt Szakács, Szabolcs Kiss, Nóra Vörhendi, Dániel Pécsi, Eszter Hegyi, Péter Hegyi, Bálint Erőss. Oral Proton Pump Inhibitors May Be as Effective as Intravenous in Peptic Ulcer Bleeding: A Systematic Review and Meta-analysis. Clin Transl Gastroenterol 2021;12:e00341
    https://doi.org/10.14309/ctg.0000000000000341
  105. Raimunda SN Brilhante, Maria G da Rocha, Jonathas S de Oliveira, Jaime DA España, Vandbergue S Pereira, Débora de SCM Castelo-Branco, Waldemiro de A Pereira-Neto, José JC Sidrim, Rossana de A Cordeiro, Marcos FG Rocha. Proton pump Inhibitors Versus Cryptococcus Species: Effects on in Vitro Susceptibility and Melanin Production . Future Microbiol. 2019;14:489
    https://doi.org/10.2217/fmb-2018-0340
  106. Syed Mohammed Basheeruddin Asdaq, Marah ALbasha, Asmaa Almutairi, Reham Alyabisi, Alaa Almuhaisni, Roaa Faqihi, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani. Use of proton pump inhibitors: An exploration of awareness, attitude and behavior of health care professionals of Riyadh, Saudi Arabia. Saudi Pharmaceutical Journal 2021;29:713
    https://doi.org/10.1016/j.jsps.2021.04.033
  107. Ana Ruiz‐Garcia, Joanna C. Masters, Laure Mendes da Costa, Robert R. LaBadie, Yali Liang, Grace Ni, Craig A. Ellery, Tanya Boutros, Zelanna Goldberg, Carlo L. Bello. Effect of food or proton pump inhibitor treatment on the bioavailability of dacomitinib in healthy volunteers. The Journal of Clinical Pharma 2016;56:223
    https://doi.org/10.1002/jcph.588
  108. Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes, Mauricio Orlando Nava Mesa. Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences. Neural Plasticity 2018;2018:1
    https://doi.org/10.1155/2018/5257285
  109. Jin Liu, Ning Huang, Ning Li, Si-Nian Liu, Min-Hui Li, Hua Li, Xing-Yan Luo, Yan-Tang Wang, Li-Mei Li, Qiang Zou, Yang Liu, Tai Yang. 2-(1H-Benzimidazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol, a Benzimidazole Derivative, Inhibits T Cell Proliferation Involving H+/K+-ATPase Inhibition. Molecules 2014;19:17173
    https://doi.org/10.3390/molecules191117173
  110. Neda O. Anastassova, Anelia Ts. Mavrova, Denitsa Y. Yancheva, Magdalena S. Kondeva-Burdina, Virginia I. Tzankova, Simeon S. Stoyanov, Boris L. Shivachev, Rositsa P. Nikolova. Hepatotoxicity and antioxidant activity of some new N,N′-disubstituted benzimidazole-2-thiones, radical scavenging mechanism and structure-activity relationship. Arabian Journal of Chemistry 2018;11:353
    https://doi.org/10.1016/j.arabjc.2016.12.003
  111. Hólmfríður Helgadóttir, Sigrún H. Lund, Sveinbjörn Gizurarson, Helge Waldum, Einar S. Björnsson. Pharmacokinetics of single and repeated oral doses of esomeprazole and gastrin elevation in healthy males and females. Scandinavian Journal of Gastroenterology 2021;56:128
    https://doi.org/10.1080/00365521.2020.1859610
  112. Neetu Soni, Namrata Soni, Rahul Maheshwari, Shreya Thakkar, Dilip Sharma, Rakesh K. Tekade, Nagaraja Sreeharsha, Muktika Tekade. The Future of Pharmaceutical Product Development and Research. 2021.
    https://doi.org/10.1016/B978-0-12-814455-8.00012-8
  113. Kyu‐Nam Kim, Sung‐Won Yang, Hyunil Kim, Seong Shin Kwak, Young‐Sang Kim, Doo‐Yeoun Cho. Acid Inhibitory Effect of a Combination of Omeprazole and Sodium Bicarbonate (CDFR0209) Compared With Delayed‐Release Omeprazole 40 mg Alone in Healthy Adult Male Subjects. Clinical Pharm in Drug Dev 2018;7:53
    https://doi.org/10.1002/cpdd.331
  114. Justyna Srebro, Witold Brniak, Aleksander Mendyk. Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives. Pharmaceutics 2022;14:2043
    https://doi.org/10.3390/pharmaceutics14102043
  115. Adam Chwiesko, Radoslaw Charkiewicz, Jacek Niklinski, Wojciech Luczaj, Elzbieta Skrzydlewska, Robert Milewski, Andrzej Baniukiewicz, Eugeniusz Wroblewski, Mariusz Rosolowski, Andrzej Dabrowski. Effects of different omeprazole dosing on gastric pH in non‐variceal upper gastrointestinal bleeding: A randomized prospective study. J of Digest Diseases 2016;17:588
    https://doi.org/10.1111/1751-2980.12393
  116. Kiyoaki Uryu, Yoshinori Imamura, Rai Shimoyama, Takahiro Mase, Yoshiaki Fujimura, Maki Hayashi, Megu Ohtaki, Keiko Otani, Makoto Hibino, Shigeto Horiuchi, Tomoya Fukui, Ryuta Fukai, Yusuke Chihara, Akihiko Iwase, Noriko Yamada, Yukihiro Tamura, Hiromasa Harada, Nobuaki Shinozaki, Toyoshi Shimada, Asuka Tsuya, Masahiro Fukuoka, Hironobu Minami. Prognostic impact of concomitant pH-regulating drugs in patients with non-small cell lung cancer receiving epidermal growth factor receptor tyrosine kinase inhibitors: the Tokushukai REAl-world Data project 01-S1. Cancer Chemother Pharmacol 2024
    https://doi.org/10.1007/s00280-024-04666-4
  117. Mehmet Aslan, Yilmaz Celik, Sevdegul Karadas, Sehmus Olmez, Adem Cifci. Liver hepatotoxicity associated with pantoprazole: a rare case report. Wien Klin Wochenschr 2014;126:390
    https://doi.org/10.1007/s00508-014-0535-3
  118. Ameena Benchamana, Hiroyuki Mori, Ormond A. MacDougald, Sunhapas Soodvilai. Regulation of adipocyte differentiation and metabolism by lansoprazole. Life Sciences 2019;239:116897
    https://doi.org/10.1016/j.lfs.2019.116897
  119. Shan Zhou, Fang-Ling Zhao, Shuang-Hu Wang, Yi-Ran Wang, Yun Hong, Quan Zhou, Pei-Wu Geng, Qing-Feng Luo, Jian-Ping Cai, Da-Peng Dai. Assessments of CYP‑inhibition‑based drug–drug interaction between vonoprazan and poziotinib in vitro and in vivo . Pharmaceutical Biology 2023;61:356
    https://doi.org/10.1080/13880209.2023.2173253
  120. Juan Jin, Cuiping Huang, Changhai Zhu, Wanni Feng, Ang He, Tuo Li, Lina Wang, Xiaolu Wang, Xiali Rao, Fangliang Gan. Pharmacokinetics, Bioequivalence, and Safety of Esomeprazole Magnesium Enteric‐Coated Capsules in Healthy Chinese Subjects. Clinical Pharm in Drug Dev 2023;12:691
    https://doi.org/10.1002/cpdd.1273
  121. S. Sobrino-Cossío, O. Teramoto-Matsubara, G. Mateos-Pérez, J.M. Abdo-Francis, J. Tawil, C. Olguín-Ramírez, A. Orozco-Gamiz, E.S. Galvis-García. In search of the grail: A race for acid suppression. Revista de Gastroenterología de México (English Edition) 2019;84:344
    https://doi.org/10.1016/j.rgmxen.2019.04.001
  122. Naren Nallapeta, Jessica L. Reynolds, Smita Bakhai. Deprescribing Proton Pump Inhibitors in an Academic, Primary Care Clinic. 2020;54:864
    https://doi.org/10.1097/MCG.0000000000001317
  123. C. Launois, P. Mulette, J. Ancel, S. Dury, J. Hagenburg, F. Lebargy, V. Dormoy, G. Deslee, J.-M. Perotin. Traitement du reflux gastro-œsophagien dans l’asthme. Revue des Maladies Respiratoires 2021;38:733
    https://doi.org/10.1016/j.rmr.2021.04.013
  124. Yuuichi Sakurai, Madoka Shiino, Hiroyuki Okamoto, Akira Nishimura, Koki Nakamura, Setsuo Hasegawa. Pharmacokinetics and Safety of Triple Therapy with Vonoprazan, Amoxicillin, and Clarithromycin or Metronidazole: A Phase 1, Open-Label, Randomized, Crossover Study. Adv Ther 2016;33:1519
    https://doi.org/10.1007/s12325-016-0374-x
  125. A. M. Amin, M. M. Omar, S. M. Abd-elhaliem, A. A. Elshanawany. Gastric ulcer localization: Potential use of 125I-omeprazole as radiotracer. Radiochemistry 2015;57:182
    https://doi.org/10.1134/S1066362215020113
  126. Qianjun Zhuang, Aijun Liao, Qingling He, Chengxia Liu, Changqing Zheng, Xing Li, Youli Liu, Bangmao Wang, Side Liu, Yan Zhang, Rong Lin, Huixin Chen, Min Deng, Yanping Tang, Chiyi He, Weijie Dai, Haitao Tang, Lei Gong, Liangping Li, Baohong Xu, Changqing Yang, Bingxi Zhou, Dongxing Su, Qinghong Guo, Bin Li, Yongjian Zhou, Xiaoyang Wang, Sujuan Fei, Huili Wu, Sichen Wei, Zhihong Peng, Jianning Wang, Yanqing Li, Hong Wang, Tianwei Deng, Shigang Ding, Fangfang Li, Minhu Chen, Yinglian Xiao. The efficacy and safety of fexuprazan in treating erosive esophagitis: a phase III, randomized, double‐blind, multicenter study. J of Gastro and Hepatol 2024;39:658
    https://doi.org/10.1111/jgh.16471
  127. I. G. Pakhomova, G. Yu. Knorring, T. N. Kochegura, E. Yu. Pavlova. Differentiated approach to the choice of PPI in a patient with GERD in the practice of an outpatient (with a clinical case). Medicinskij sovet 2021:118
    https://doi.org/10.21518/2079-701X-2020-21-118-125
  128. Miao Yan, Zhu-feng Wu, Dan Tang, Feng Wang, Yi-wen Xiao, Ping Xu, Bi-kui Zhang, Yi-ping Liu, Da-xiong Xiang, Hoan Linh Banh. The impact of proton pump inhibitors on the pharmacokinetics of voriconazole in vitro and in vivo. Biomedicine & Pharmacotherapy 2018;108:60
    https://doi.org/10.1016/j.biopha.2018.08.121
  129. Prashanth Porayette, David Flockhart, Sandeep K. Gupta. One Size Fits One: Pharmacogenetics in Gastroenterology. Clinical Gastroenterology and Hepatology 2014;12:565
    https://doi.org/10.1016/j.cgh.2014.01.035
  130. TAI YANG, MIN-HUI LI, JIN LIU, NING HUANG, NING LI, SI-NIAN LIU, YANG LIU, TAO ZHANG, QIANG ZOU, HUA LI. Benzimidazole derivative, BMT-1, induces apoptosis in multiple myeloma cells via a mitochondrial-mediated pathway involving H+/K+-ATPase inhibition. 2014;31:2743
    https://doi.org/10.3892/or.2014.3122
  131. Steven C. Mitini-Nkhoma, Narmada Fernando, G. K. D. Ishaka, Shiroma M. Handunnetti, Sisira L. Pathirana, Alexander S. Apt. Ion Transport Modulators as Antimycobacterial Agents. Tuberculosis Research and Treatment 2020;2020:1
    https://doi.org/10.1155/2020/3767915
  132. Jung-Hyun Lim, Jongbeom Shin, Jin-Seok Park. Effect of a Proton Pump Inhibitor on the Duodenum Microbiome of Gastric Ulcer Patients. Life 2022;12:1505
    https://doi.org/10.3390/life12101505
  133. Kenji Ikemura, Shunichi Hiramatsu, Masahiro Okuda. Drug Repositioning of Proton Pump Inhibitors for Enhanced Efficacy and Safety of Cancer Chemotherapy. Front. Pharmacol. 2017;8
    https://doi.org/10.3389/fphar.2017.00911
  134. Emre Yucel, Mesut Sancar, Aylin Yucel, Betul Okuyan. Adverse drug reactions due to drug–drug interactions with proton pump inhibitors: assessment of systematic reviews with AMSTAR method. Expert Opinion on Drug Safety 2016;15:223
    https://doi.org/10.1517/14740338.2016.1128413
  135. Ho Kang, So Kim, Ji Kim, Eun Kim, Hyo Choi, Hyun Lim, Joo-Hee Kim, Ha Park, Nan Kim, Sangkyoon Hong, Kyung Choi, Mi Kwon. Association between Migraines and Prior Proton Pump Inhibitor Use: A Nested Case-Control Study Using a National Health Screening Cohort. Pharmaceuticals 2022;15:1385
    https://doi.org/10.3390/ph15111385
  136. Martin Michaelis, Malte C. Kleinschmidt, Denisa Bojkova, Holger F. Rabenau, Mark N. Wass, Jindrich Cinatl Jr.. Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2. Front. Microbiol. 2019;10
    https://doi.org/10.3389/fmicb.2019.02790
  137. Lihua Wu, Jian Liu, Yunliang Zheng, You Zhai, Meihua Lin, Guolan Wu, Duo Lv, Jianzhong Shentu. Pharmacokinetic/Pharmacodynamic Evaluation of Dexlansoprazole Infusion Injection Compared with Lansoprazole in Healthy Chinese Adults. Clin Drug Investig 2019;39:953
    https://doi.org/10.1007/s40261-019-00824-2
  138. Chih-Ming Liang, Ming-Te Kuo, Pin-I Hsu, Chao-Hung Kuo, Wei-Chen Tai, Shih-Cheng Yang, Keng-Liang Wu, Hsing-Ming Wang, Chih-Chien Yao, Cheng-En Tsai, Yao-Kuang Wang, Jiunn-Wei Wang, Chih-Fang Huang, Deng-Chyang Wu. First-week clinical responses to dexlansoprazole 60 mg and esomeprazole 40 mg for the treatment of grades A and B gastroesophageal reflux disease. WJG 2017;23:8395
    https://doi.org/10.3748/wjg.v23.i47.8395
  139. Wen-Tao Xu, Xiang-Bo Xu, Tian-Shu Ren, Xing-Shun Qi. Vonoprazan for treatment of gastroesophageal reflux disease: Research advances. WCJD 2021;29:1248
    https://doi.org/10.11569/wcjd.v29.i21.1248
  140. Benjamin Ka Seng Thong, Soelaiman Ima-Nirwana, Kok-Yong Chin. Proton Pump Inhibitors and Fracture Risk: A Review of Current Evidence and Mechanisms Involved. IJERPH 2019;16:1571
    https://doi.org/10.3390/ijerph16091571
  141. Huma Hameed, Jahangir Hussain, Ana Cláudia Paiva-Santos, Muhammad Zaman, Ali Hamza, Irsa Sajjad, Faria Asad. Comprehensive insights on treatment modalities with conventional and herbal drugs for the treatment of duodenal ulcers. Naunyn-Schmiedeberg's Arch Pharmacol 2024
    https://doi.org/10.1007/s00210-024-03178-5
  142. Aneta Kiecka, Marian Szczepanik. Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics. Pharmacol. Rep 2023;75:791
    https://doi.org/10.1007/s43440-023-00489-x
  143. Danilo Menichelli, Gianluca Gazzaniga, Francesco Del Sole, Arianna Pani, Pasquale Pignatelli, Daniele Pastori. Acute upper and lower gastrointestinal bleeding management in older people taking or not taking anticoagulants: a literature review. Front. Med. 2024;11
    https://doi.org/10.3389/fmed.2024.1399429
  144. Abdrrahman Shemsu Surur, Lukas Schulig, Andreas Link. Interconnection of sulfides and sulfoxides in medicinal chemistry. Arch. Pharm. Chem. Life Sci. 2018:1800248
    https://doi.org/10.1002/ardp.201800248
  145. Jeremy Klein, Robert T. Kavitt. Gastroesophageal Reflux Disease. 2018.
    https://doi.org/10.1007/978-3-031-48241-0_8
  146. M. Alexandra Lake, Kristin N. Adams, Feilin Nie, Elaine Fowler, Amit K. Verma, Silvia Dei, Elisabetta Teodori, David R. Sherman, Paul H. Edelstein, David R. Spring, Mark Troll, Lalita Ramakrishnan. The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance . Proc. Natl. Acad. Sci. U.S.A. 2023;120
    https://doi.org/10.1073/pnas.2215512120
  147. Hyunsoo Kim, Yoon Soo Hwang, Mingi Kim, Seung Bum Park. Recent advances in the development of covalent inhibitors. RSC Med. Chem. 2021;12:1037
    https://doi.org/10.1039/D1MD00068C
  148. Young Dal Lee, Sung Eun Kim, Seun Ja Park, Moo In Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung, Jiyun Song. Efficacy of Seven-day High-dose Esomeprazole-based Triple Therapy versus Seven-day Standard Dose Non-esomeprazole-based Triple Therapy as the First-line Treatment of Patients with Helicobacter pylori Infection. Korean J Gastroenterol 2020;76:142
    https://doi.org/10.4166/kjg.2020.76.3.142
  149. M. Serratice, B. Bertrand, E. F. J. Janssen, E. Hemelt, A. Zucca, F. Cocco, M. A. Cinellu, A. Casini. Gold(i) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro. Med. Chem. Commun. 2014;5:1418
    https://doi.org/10.1039/C4MD00241E
  150. Alba Rocco, Debora Compare, Costantino Sgamato, Pietro Coccoli, Paolo Chiodini, Gerardo Nardone. Impact of proton pump inhibitors on cytochrome P450 activity assessed by 13C‐aminopyrine breath test in patients with cirrhosis. Aliment Pharmacol Ther 2021;53:608
    https://doi.org/10.1111/apt.16239
  151. Hideki Mori, Hidekazu Suzuki. Role of Acid Suppression in Acid-related Diseases: Proton Pump Inhibitor and Potassium-competitive Acid Blocker. J Neurogastroenterol Motil 2019;25:6
    https://doi.org/10.5056/jnm18139
  152. Hee Jin Kim, Nayoung Kim, Ji Hyun Park, Sunkyu Choi, Cheol Min Shin, Ok Jae Lee. Helicobacter pylori Eradication Induced Constant Decrease in Interleukin- 1B Expression over More Than 5 Years in Patients with Gastric Cancer and Dysplasia. Gut and Liver 2020;14:735
    https://doi.org/10.5009/gnl19312
  153. Lu Feng, Jing Fu, Zhaoqi Dong. Somatostatin plus Gastroscopic Administration of Omeprazole for the Treatment of Acute Upper Gastrointestinal Bleeding: An Exploration of a Promising Alternative. Evidence-Based Complementary and Alternative Medicine 2022;2022:1
    https://doi.org/10.1155/2022/6329592
  154. Louis G. Mueller, Barbara S. Slusher, Takashi Tsukamoto. Empirical Analysis of Drug Targets for Nervous System Disorders. ACS Chem. Neurosci. 2024
    https://doi.org/10.1021/acschemneuro.3c00676
  155. King-Wah Chiu, Toshiaki Nakano, Kuang-Den Chen, Li-Wen Hsu, Chia-Yun Lai, Ching-Yin Huang, Yu-Fan Cheng, Shigeru Goto, Chao-Long Chen. Cytochrome P450 in living donor liver transplantation. J Biomed Sci 2015;22
    https://doi.org/10.1186/s12929-015-0140-4
  156. Boriana K. Tchernookova, Michael W. Gongwer, Alexis George, Brock Goeglein, Alyssa M. Powell, Hannah L. Caringal, Thomas Leuschner, Anna G. Phillips, Adam W. Schantz, Lech Kiedrowski, Richard Chappell, Matthew A. Kreitzer, Robert Paul Malchow. ATP-mediated increase in H+ flux from retinal Müller cells: a role for Na+/H+ exchange. Journal of Neurophysiology 2021;125:184
    https://doi.org/10.1152/jn.00546.2020
  157. Dong Sun, Chunyu Wang, Yanxia Fan, Jingkai Gu. Identification, structure elucidation and origin of a common pyridinium-thiocyanate intermediate in electrospray mass spectrometry among the benziamidazole-class proton pump inhibitors. Journal of Pharmaceutical Analysis 2023;13:683
    https://doi.org/10.1016/j.jpha.2023.04.011
  158. Cynthia Kanagaratham, Yasmeen S. El Ansari, Benjamin F. Sallis, Brianna-Marie A. Hollister, Owen L. Lewis, Samantha C. Minnicozzi, Michiko K. Oyoshi, Rachel Rosen, Samuel Nurko, Edda Fiebiger, Hans C. Oettgen. Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice. Journal of Allergy and Clinical Immunology 2020;146:884
    https://doi.org/10.1016/j.jaci.2020.02.032
  159. Luana Lugini, Cristina Federici, Martina Borghi, Tommaso Azzarito, Maria Lucia Marino, Albino Cesolini, Enrico Pierluigi Spugnini, Stefano Fais. Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect. Journal of Enzyme Inhibition and Medicinal Chemistry 2016;31:538
    https://doi.org/10.3109/14756366.2015.1046062
  160. Tadayuki Oshima, Hiroto Miwa. Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases. J Neurogastroenterol Motil 2018;24:334
    https://doi.org/10.5056/jnm18029
  161. Chia‐Chu Yeh, Chieh‐Chang Chen, Chien‐Chuan Chen, Ming‐Lun Han, Jia‐Feng Wu, Hsiu‐Po Wang, Ming‐Shiang Wu, Ping‐Huei Tseng. Characteristics of the esophageal microbiome in patients with achalasia and its changes before and after peroral endoscopic myotomy: A pilot study. J of Gastro and Hepatol 2023;38:1307
    https://doi.org/10.1111/jgh.16192
  162. Longgang Niu, Yu Liu, Xiaomin Hou, Lijuan Cui, Jiangtao Li, Xuanping Zhang, Mingsheng Zhang. Extracellular acidosis contracts coronary but neither renal nor mesenteric artery via modulation of H+,K+‐ATPase, voltage‐gated K+ channels and L‐type Ca2+ channels. Experimental Physiology 2014;99:995
    https://doi.org/10.1113/expphysiol.2014.078634
  163. Nayoung Kim, Yoon Jin Choi. Helicobacter pylori. 2014.
    https://doi.org/10.1007/978-981-97-0013-4_4
  164. Mario Nagase, Hitoshi Shimada, Masahiro Nii, Shinya Ueda, Mitsuo Higashimori, Katsuomi Ichikawa, Li Zhang, Li Zhou, Yingxue Chen, Diansong Zhou, James Dunyak, Nidal Al‐Huniti. Population pharmacokinetic analysis of esomeprazole in Japanese subjects with various CYP2C19 phenotypes. J Clin Pharm Ther 2020;45:1030
    https://doi.org/10.1111/jcpt.13129
  165. Jumpei Saito, Naho Yakuwa, Noriko Sandaiji, Hiroyo Kawasaki, Kayoko Kaneko, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Atsuko Murashima. Esomeprazole During Pregnancy and Lactation: Esomeprazole Levels in Maternal Serum, Cord Blood, Breast Milk, and the Infant's Serum. Breastfeeding Medicine 2020;15:598
    https://doi.org/10.1089/bfm.2020.0175
  166. Christopher J. Bowman, Nathalie Becourt‐Lhote, Virginie Boulifard, Rüdiger Cordts, Solange Corriol‐Rohou, Brian Enright, Linda Erkman, Jayne Harris, Andreas Hartmann, Jan Hilpert, Sophie Kervyn, Britta Mattson, LaRonda Morford, Mireille Muller, Marcy Powell, Zhanna Sobol, Rajamuthu Srinivasan, Claudia Stark, Kary E. Thompson, Katie J. Turner, Paul Barrow. Science‐Based Approach to Harmonize Contraception Recommendations in Clinical Trials and Pharmaceutical Labels. Clin Pharma and Therapeutics 2023;113:226
    https://doi.org/10.1002/cpt.2602
  167. Olena Kis, Sharon L. Walmsley, Reina Bendayan. In Vitro and In Situ Evaluation of pH-Dependence of Atazanavir Intestinal Permeability and Interactions with Acid-Reducing Agents. Pharm Res 2014;31:2404
    https://doi.org/10.1007/s11095-014-1336-0
  168. Cheol Min Shin. Acid Suppressive Drugs. Korean J Helicobacter Up Gastrointest Res 2022;22:119
    https://doi.org/10.7704/kjhugr.2022.0016
  169. Amit Kumar, Rajnish Kumar, John Flanagan, Bengt Långström, Lars Björndahl, Taher Darreh-Shori. Esomeprazole reduces sperm motility index by targeting the spermic cholinergic machinery: A mechanistic study for the association between use of proton pump inhibitors and reduced sperm motility index. Biochemical Pharmacology 2020;182:114212
    https://doi.org/10.1016/j.bcp.2020.114212
  170. Maria Marinescu. Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities. Antibiotics 2021;10:1002
    https://doi.org/10.3390/antibiotics10081002
  171. Danny Jenkins, Ines Modolell. Proton pump inhibitors. BMJ 2023:e070752
    https://doi.org/10.1136/bmj-2022-070752
  172. Saswati Bhattacharya, Jasmina Khanam, Pradipta Sarkar, Tapan Kumar Pal. A chemotherapeutic approach targeting the acidic tumor microenvironment: combination of a proton pump inhibitor and paclitaxel for statistically optimized nanotherapeutics. RSC Adv. 2019;9:240
    https://doi.org/10.1039/C8RA08924H
  173. Paulius Jonaitis, Laimas Jonaitis, Juozas Kupcinskas. Role of Genetic Polymorphisms of Cytochrome P450 2C19 in Pantoprazole Metabolism and Pantoprazole-based Helicobacter pylori Eradication Regimens. CDM 2020;21:830
    https://doi.org/10.2174/1389200221666200514081442
  174. David B. Stewart, John P. Hegarty. Correlation between virulence gene expression and proton pump inhibitors and ambient pH in Clostridium difficile: results of an in vitro study. 2013;62:1517
    https://doi.org/10.1099/jmm.0.059709-0
  175. Edwin E. Escobar, Wanjie Yang, Michael B. Lanzillotti, Kyle J. Juetten, Samuel Shields, Dionicio Siegel, Y. Jessie Zhang, Jennifer S. Brodbelt. Tracking Inhibition of Human Small C-Terminal Domain Phosphatase 1 Using 193 nm Ultraviolet Photodissociation Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2024;35:1330
    https://doi.org/10.1021/jasms.4c00098
  176. Chuan Tian, Lixin Zhu, Dan Yu, Zhiwei Cao, Tingguo Kang, Ruixin Zhu. The Stereoselectivity of CYP2C19 on R‐ and S‐isomers of Proton Pump Inhibitors. Chem Biol Drug Des 2014;83:610
    https://doi.org/10.1111/cbdd.12274
  177. Megan Walsh, Stefano Fais, Enrico Pierluigi Spugnini, Salvador Harguindey, Tareq Abu Izneid, Licia Scacco, Paula Williams, Cinzia Allegrucci, Cyril Rauch, Ziad Omran. Proton pump inhibitors for the treatment of cancer in companion animals. J Exp Clin Cancer Res 2015;34
    https://doi.org/10.1186/s13046-015-0204-z
  178. G. Sachs, E. A. Marcus, Y. Wen, K. Munson. Editorial: control of acid secretion. Aliment Pharmacol Ther 2018;48:682
    https://doi.org/10.1111/apt.14864
  179. Carlos Arturo Rojas, Mario Sepúlveda Copete, Jairo Alberto García Abadía, Héctor Raúl Echavarría Abad, Fernando Rosso Suárez, Andrés Fernando Jiménez, Andrés Mauricio Castro Llanos. Un ensayo clínico piloto de la efectividad clínica de dos presentaciones de esomeprazol . Rev Colomb Gastroenterol 2019;34:261
    https://doi.org/10.22516/25007440.335
  180. Mohammed M Mehanna, Amina Tarek Mneimneh, Souraya Domiati, Ahmed N Allam.

    Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity

    . IJN 2020;Volume 15:10099
    https://doi.org/10.2147/IJN.S288552
  181. Alia Erum, Ume Ruqia Tulain, Asma Maqsood, Sidra, Nadia Shamshad Malik, Ayesha Rashid, Laraib Zia Warraich. Fabrication and comparative appraisal of natural and synthetic polymeric pH responsive nanoparticles for effective delivery of dexlansoprazole. Polym. Bull. 2023;80:9113
    https://doi.org/10.1007/s00289-022-04489-4
  182. Hua‐Ching Chang, Yin‐Shuo Chang, Kuo‐Hsien Wang, Tiong Cheng, Hsiou‐Hsin Tsai. Esomeprazole‐induced ashy dermatosis‐like drug eruptions. Aust J Dermatology 2019;60
    https://doi.org/10.1111/ajd.12978
  183. Michael Burger, Caroline Schmitt-Koopmann, Jean-Christophe Leroux. DNA unchained: two assays to discover and study inhibitors of the DNA clustering function of barrier-to-autointegration factor. Sci Rep 2020;10
    https://doi.org/10.1038/s41598-020-69246-x
  184. Joe S. Smith, Kailee Bennett, Ryan Flynn, Jesse Gebert, Pierre-Yves Mulon, Jessica D. Garcia, Lainey Harvill, Olivia Escher, Lisa Sams Ebner, Joan Bergman, Sherry Cox, Gade Kalyani. Pharmacokinetics and pharmacodynamics of intravenously and subcutaneously administered pantoprazole in sheep (Ovis aries). PLoS ONE 2024;19:e0304533
    https://doi.org/10.1371/journal.pone.0304533
  185. Philip Woodland, Gehanjali Amarasinghe, Daniel Sifrim. Emerging therapeutic options in GERD. Best Practice & Research Clinical Gastroenterology 2013;27:455
    https://doi.org/10.1016/j.bpg.2013.06.006
  186. Gautham Yepuri, Roman Sukhovershin, Timo Z. Nazari-Shafti, Michael Petrascheck, Yohannes T. Ghebre, John P. Cooke. Proton Pump Inhibitors Accelerate Endothelial Senescence. Circulation Research 2016;118
    https://doi.org/10.1161/CIRCRESAHA.116.308807
  187. Madeleine Strickland, Lorna S. Ehrlich, Susan Watanabe, Mahfuz Khan, Marie-Paule Strub, Chi-Hao Luan, Michael D. Powell, Jonathan Leis, Nico Tjandra, Carol A. Carter. Tsg101 chaperone function revealed by HIV-1 assembly inhibitors. Nat Commun 2017;8
    https://doi.org/10.1038/s41467-017-01426-2
  188. Ning-Ning Liu, Julia R. Köhler. Antagonism of Fluconazole and a Proton Pump Inhibitor against Candida albicans. Antimicrob Agents Chemother 2016;60:1145
    https://doi.org/10.1128/AAC.02043-15
  189. Alexandru Mester, Dragos Apostu, Lidia Ciobanu, Andra Piciu, Ondine Lucaciu, Radu Septimiu Campian, Marian Taulescu, Simion Bran. The impact of proton pump inhibitors on bone regeneration and implant osseointegration. Drug Metabolism Reviews 2019;51:330
    https://doi.org/10.1080/03602532.2019.1610767
  190. Negar Kanounisabet, Ahmad Mogharehabed, Nakisa Torabinia, SeyedehMarzieh Hashemi Nejad, Jaber Yaghini. Effect of systemic administration of omeprazole on osseointegration around titanium dental implants: A histomorphometric study in dogs. Dent Res J 2021;18:43
    https://doi.org/10.4103/1735-3327.318938
  191. Xiaoxia Zhao, Ning Zhang, Yingying Huang, Xiaojing Dou, Xiaolin Peng, Wei Wang, Zhe Zhang, Ran Wang, Yuling Qiu, Meihua Jin, Dexin Kong. Lansoprazole Alone or in Combination With Gefitinib Shows Antitumor Activity Against Non-small Cell Lung Cancer A549 Cells in vitro and in vivo. Front. Cell Dev. Biol. 2021;9
    https://doi.org/10.3389/fcell.2021.655559
  192. Tigran Makunts, Isaac V. Cohen, Linda Awdishu, Ruben Abagyan. Analysis of postmarketing safety data for proton-pump inhibitors reveals increased propensity for renal injury, electrolyte abnormalities, and nephrolithiasis. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-39335-7
  193. Sevim Bavbek, Seçil Kepil Özdemir, Patrizia Bonadonna, Marina Atanaskovic‐Markovic, Annick Barbaud, Knut Brockow, Jose Laguna Martinez, Alla Nakonechna, Mauro Pagani, Alessandra Arcolacı, Carla Lombardo, Maria J. Torres. Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper. Allergy 2024;79:552
    https://doi.org/10.1111/all.15961
  194. Hao Wang, Yantong Sun, Yan Yang, Wei Guo, Mi Zheng, Weiping Zhang, J Paul Fawcett, Jingkai Gu. Application of A High-Throughput, Parallel HPLC System for Quantitative Chiral Analysis of Pantoprazole. Bioanalysis 2015;7:2981
    https://doi.org/10.4155/bio.15.215
  195. Elizabeth J. Thompson, Angela Jeong, Victória E. Helfer, Valentina Shakhnovich, Andrea Edginton, Stephen J. Balevic, Laura P. James, David N. Collier, Ravinder Anand, Daniel Gonzalez. Physiologically‐based pharmacokinetic modeling of pantoprazole to evaluate the role of CYP2C19 genetic variation and obesity in the pediatric population. CPT Pharmacom & Syst Pharma 2024
    https://doi.org/10.1002/psp4.13167
  196. Chongzhuang Tang, Zhaoqiang Chen, Xiaojian Dai, Weiliang Zhu, Dafang Zhong, Xiaoyan Chen. Mechanism of Reductive Metabolism and Chiral Inversion of Proton Pump Inhibitors. Drug Metab Dispos 2019;47:657
    https://doi.org/10.1124/dmd.118.086090
  197. Sergio Enríquez-Flores, Luis A. Flores-López, Ignacio De la Mora-De la Mora, Itzhel García-Torres, Isabel Gracia-Mora, Pedro Gutiérrez-Castrellón, Cynthia Fernández-Lainez, Yoalli Martínez-Pérez, Alberto Olaya-Vargas, Paul de Vos, Gabriel López-Velázquez. Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer. Sci Rep 2022;12
    https://doi.org/10.1038/s41598-022-08051-0
  198. G.D. Marijn Veerman, Daan P. Hurkmans, Marthe S. Paats, Esther Oomen-de Hoop, Cor H. van der Leest, Eric R.E. van Thiel, Joachim G.J.V. Aerts, Roelof W. van Leeuwen, Anne-Marie C. Dingemans, Ron H.J. Mathijssen. Influence of esomeprazole on the bioavailability of afatinib: A pharmacokinetic cross-over study in patients with non-small cell lung cancer. Biomedicine & Pharmacotherapy 2022;155:113695
    https://doi.org/10.1016/j.biopha.2022.113695
  199. Kentaro Sugano. Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date. Therap Adv Gastroenterol 2018;11:1756283X1774577
    https://doi.org/10.1177/1756283X17745776
  200. Naoko Yamagishi, Yuta Yamamoto, Toshio Nishi, Takao Ito, Yoshimitsu Kanai, Wei Hsum Yap. Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK/ARE/Nrf2 pathway. PLoS ONE 2023;18:e0287788
    https://doi.org/10.1371/journal.pone.0287788
  201. S Setiadji, C D D Sundari, M A Ramdhani, A B K Umam, A L Ivansyah. Theoretical Investigation of Inclusion Complex between Omeprazole Enantiomers and Carboxymethyl-β-Cyclodextrin. IOP Conf. Ser.: Mater. Sci. Eng. 2018;288:012138
    https://doi.org/10.1088/1757-899X/288/1/012138
  202. Aparna Das, Muhammad Waqar Ashraf, Bimal Krishna Banik. Thione Derivatives as Medicinally Important Compounds. ChemistrySelect 2021;6:9069
    https://doi.org/10.1002/slct.202102398
  203. Sufeng Zhou, Lijun Xie, Chen Zhou, Lu Wang, Juan Chen, Sijia Ding, Bei Zhu, Mei Su, Feng Shao. Keverprazan, a novel potassium‐competitive acid blocker: Multiple oral doses safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy subjects. Clinical Translational Sci 2023;16:1911
    https://doi.org/10.1111/cts.13598
  204. Endale Mulugeta, Yoseph Samuel, Saleh Ahmed Mohamed. Synthesis of Benzimidazole-Sulfonyl Derivatives and Their Biological Activities. Biochemistry Research International 2022;2022:1
    https://doi.org/10.1155/2022/7255299
  205. Filippo Basagni, Michela Rosini, Michael Decker. Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes. ChemMedChem 2020;15:1374
    https://doi.org/10.1002/cmdc.202000298
  206. Dawei Yu, Tuo Wang, Yushuai Liang, Jibao Liu, Jiaxi Zheng, Meixue Chen, Yuansong Wei. Delivery and effects of proton pump inhibitor on anaerobic digestion of food and kitchen waste under ammonia stress. Journal of Hazardous Materials 2021;416:126211
    https://doi.org/10.1016/j.jhazmat.2021.126211
  207. Madeleine Strickland, David Nyenhuis, Susan M. Watanabe, Nico Tjandra, Carol A. Carter. Novel Tsg101 Binding Partners Regulate Viral L Domain Trafficking. Viruses 2021;13:1147
    https://doi.org/10.3390/v13061147
  208. S. Tommasi, D. J. Elliot, J. A. Hulin, B. C. Lewis, M. McEvoy, A. A. Mangoni. Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance. Sci Rep 2017;7
    https://doi.org/10.1038/s41598-017-03069-1
  209. Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee. Exploring Differences in Pharmacometrics of Rabeprazole between Genders via Population Pharmacokinetic–Pharmacodynamic Modeling. Biomedicines 2023;11:3021
    https://doi.org/10.3390/biomedicines11113021
  210. Gaurav Taneja, Punniyakoti V. Thanikachalam, Satyendra K. Rajput. Dose and time-dependent toxicological impact of pantoprazole on vascular endothelium and renal tissue. Toxicology Letters 2020;333:97
    https://doi.org/10.1016/j.toxlet.2020.07.031
  211. Nayoung Kim, Yoon Jin Choi. Helicobacter pylori. 2020.
    https://doi.org/10.1007/978-981-287-706-2_4
  212. Jeroen M. Schuitenmaker, Thijs Kuipers, André J.P.M. Smout, Paul Fockens, Albert J. Bredenoord. Systematic review: Clinical effectiveness of interventions for the treatment of nocturnal gastroesophageal reflux. Neurogastroenterology Motil 2022;34
    https://doi.org/10.1111/nmo.14385
  213. Yu. V. Evsyutina. How to Make the Right Choice of Proton Pump Inhibitor for Patients with Gastroesophageal Reflux Disease?. Rossijskij žurnal gastroènterologii, gepatologii, koloproktologii 2023;33:68
    https://doi.org/10.22416/1382-4376-2023-33-1-68-76
  214. Stefano Fais, Yoshinori Marunaka. The Acidic Microenvironment: Is It a Phenotype of All Cancers? A Focus on Multiple Myeloma and Some Analogies with Diabetes Mellitus. Cancers 2020;12:3226
    https://doi.org/10.3390/cancers12113226
  215. Krista L. Niece, Natalie K. Boyd, Kevin S. Akers. In Vitro Study of the Variable Effects of Proton Pump Inhibitors on Voriconazole . Antimicrob Agents Chemother 2015;59:5548
    https://doi.org/10.1128/AAC.00884-15
  216. Linda Purnamawati Suherman, Pudjiastuti Kartidjo, Iis Rukmawati, Vina Septiani, Fazrin Azzura. Dyspepsia Drug Use Pattern of Outpatients in a Public Health Center in Batununggal District Bandung. Borneo J Pharm 2021;4:345
    https://doi.org/10.33084/bjop.v4i4.1987
  217. K Manimekalai, R Sudar Codi, Navinraja Komal Veererathinakumar, Vimala Ananthy. Potassium-competitive Acid Blocker: A Newer Target in the Treatment of Acid Peptic Disorder. 2023;6:33
    https://doi.org/10.5005/jp-journals-10082-03182
  218. Nihal El Rouby, John J. Lima, Julie A. Johnson. Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine. Expert Opinion on Drug Metabolism & Toxicology 2018;14:447
    https://doi.org/10.1080/17425255.2018.1461835
  219. Xiuyu Sui, Jin Guan, Xiaoyu Li, Lei Gu, Feng Yan, Shuang Shi, Dongxiang Zhang. Preparation of a polydopamine/β‐cyclodextrin coated open tubular capillary electrochromatography column and application for enantioseparation of five proton pump inhibitors. J of Separation Science 2021;44:3295
    https://doi.org/10.1002/jssc.202100298
  220. Shuqin Zhou, Debra J. Skaar, Pamala A. Jacobson, R. Stephanie Huang. Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit. Front. Pharmacol. 2018;9
    https://doi.org/10.3389/fphar.2018.01436
  221. Yu Kyung Cho, Myung‐Gyu Choi, Suck Chei Choi, Kee Myung Lee, Tae Oh Kim, Soo‐Heon Park, Jeong Seop Moon, Yun Jeong Lim, Dae Hwan Kang, Gab Jin Cheon, Gwang Ho Baik, Kyoung Oh Kim, Kwang Bum Cho, Jin Seok Jang, Jong‐Jae Park, Byoung Kwan Son, Hye‐Kyung Jung, Byung‐Wook Kim, Sung Kuk Kim, Soo Teik Lee, Jae Myung Cha, Ah Rong Kim, Eun Ji Kim, Hyun Wook Park, Geun Seog Song. Randomised clinical trial: tegoprazan, a novel potassium‐competitive acid blocker, or lansoprazole in the treatment of gastric ulcer. Aliment Pharmacol Ther 2020;52:789
    https://doi.org/10.1111/apt.15865
  222. Michael Kukulka, Sai Nudurupati, Maria Claudia Perez. Pharmacokinetics and pharmacodynamics of an orally disintegrating tablet formulation of dexlansoprazole. Therap Adv Gastroenterol 2016;9:759
    https://doi.org/10.1177/1756283X16670073
  223. Regis R Vieira, Luís Eduardo S Fontes, Rafael L Pacheco, Marcos AP Fernandes, Paloma P Malta, Rachel Riera. Proton pump inhibitor- and clarithromycin-based triple therapies for Helicobacter pylori eradication. 2020;2021
    https://doi.org/10.1002/14651858.CD013734
  224. Ruben Gomez-Sanchez, Stephen Besley, Zoe Zeliku, Robert J. Young. Method Development and Application of an Accelerated Solution Stability Screen for Drug Discovery. SLAS Discovery 2020;25:1191
    https://doi.org/10.1177/2472555220931795
  225. Lateef Ahmad, Zafar Iqbal, Yasar Shah, D. G. Watson, Abad Khan, Muhammad Imran Khan, Fazli Khuda, Abbas Khan, Fazli Nasir. Simple and Fast Liquid Chromatography–Mass Spectrometry (LC–MS) Method for the Determination of Omeprazole, 5-hydroxyomeprazole, and Omeprazole Sulphone in Human Plasma. Journal of Liquid Chromatography & Related Technologies 2015;38:692
    https://doi.org/10.1080/10826076.2014.951763
  226. Elise Pape, Delphine Michel, Julien Scala‐Bertola, Thomas Schiestel, Alexandre Harlé, Stéphane Bouchet, Audrey Contet, Cécile Pochon, Nicolas Gambier. Effect of esomeprazole on the oral absorption of dasatinib in a patient with Philadelphia‐positive acute lymphoblastic leukemia. Brit J Clinical Pharma 2016;81:1195
    https://doi.org/10.1111/bcp.12895
  227. Xianghong Zhao, Zhongqiu Zhang, Fang Lu, Mengqiu Xiong, Liping Jiang, Ke Tang, Min Fu, Yu Wu, Bangshun He. Effects of CYP2C19 genetic polymorphisms on the cure rates of H. pylori in patients treated with the proton pump inhibitors: An updated meta-analysis. Front. Pharmacol. 2022;13
    https://doi.org/10.3389/fphar.2022.938419
  228. NohaMahmoud Elkhodary, KhaledAbdalkader Farrag, AmanyMahmoud Elokaby, GamalAbd El-Hay Omran. Efficacy and safety of 7 days versus 10 days triple therapy based on levofloxacin-dexlansoprazole for eradication of Helicobacter pylori: A pilot randomized trial. Indian J Pharmacol 2020;52:356
    https://doi.org/10.4103/ijp.IJP_364_19
  229. Sagar D. Sardesai, Alexandra Thomas, Christopher Gallagher, Filipa Lynce, Yvonne Lynn Ottaviano, Tarah Jean Ballinger, Bryan P. Schneider, Anna Maria Storniolo, Amber Bauchle, Sandra K. Althouse, Susan M. Perkins, Andrea R. Masters, Robert E. Stratford, Zizheng Dong, Jing-Yuan Liu, Jian-Ting Zhang, Kathy D. Miller. Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in Patients with Operable TNBC. 2021;27:5810
    https://doi.org/10.1158/1078-0432.CCR-21-0493
  230. Harini Sri Rethinavel, Divya Bharathi Selvaraj, Sathya Jeevitha Balakrishnan, Jemi Feiona Vergil Andrews, Jerly Helan Mary Joseph, Mahesh Kandasamy. Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder. Heliyon 2022;8:e09787
    https://doi.org/10.1016/j.heliyon.2022.e09787
  231. Loren Laine, Kenneth DeVault, Philip Katz, Stefan Mitev, John Lowe, Barbara Hunt, Stuart Spechler. Vonoprazan Versus Lansoprazole for Healing and Maintenance of Healing of Erosive Esophagitis: A Randomized Trial. Gastroenterology 2023;164:61
    https://doi.org/10.1053/j.gastro.2022.09.041
  232. Karim Kheir, Omar Al Jassem, Georgio El Koubayati, Fady Haddad. A Case of Severe Proton Pump Inhibitor-Induced Hypomagnesemia Refractory to Continuous Oral and Intravenous Magnesium Replenishment. 2024
    https://doi.org/10.7759/cureus.54483
  233. Natalia Estrada-Ortiz, Elena Lopez-Gonzales, Ben Woods, Stefan Stürup, Inge A. M. de Graaf, Geny M. M. Groothuis, Angela Casini. Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands. 2019;8:885
    https://doi.org/10.1039/c9tx00149b
  234. Steven C. Mitini-Nkhoma, Narmada Fernando, G. K. D. Ishaka, Shiroma M. Handunnetti, Sisira L. Pathirana, Enrique Ortega. Ion Transport Modulators Differentially Modulate Inflammatory Responses in THP-1-Derived Macrophages. Journal of Immunology Research 2021;2021:1
    https://doi.org/10.1155/2021/8832586
  235. Charbel Fadel, Beata Łebkowska-Wieruszewskac, Firas Serih, Andrew Lisowski, Amnart Poapolathep, Mario Giorgi. Comparative pharmacokinetics of intravenous and subcutaneous pantoprazole in sheep and goats. The Veterinary Journal 2024;305:106138
    https://doi.org/10.1016/j.tvjl.2024.106138
  236. Olha V. Makarenko, Malika M. Karimova, Alona M. Masheiko, Nataliia M. Onul. QUALIMETRIC ANALYSIS OF PROTON PUMP INHIBITORS IN UKRAINE. Wiad Lek 2019;72:1769
    https://doi.org/10.36740/WLek201909212
  237. Manna Semere Gebreyesus, Eric H. Decloedt, Catherine A. Cluver, Nicole G. M. Hunfeld, Hólmfríður Helgadóttir, Einar S. Björnsson, Roeland E. Wasmann, Paolo Denti. Population pharmacokinetics of esomeprazole in patients with preterm preeclampsia. Brit J Clinical Pharma 2022;88:4639
    https://doi.org/10.1111/bcp.15416
  238. Zhimin Chen, Fangliang Gan, Xiali Rao, Xiaoxiao Huang, Huafang Chen. Pharmacokinetics, Bioequivalence, and Safety Studies of Pantoprazole Sodium Enteric‐Coated Tablets in Healthy Subjects. Clinical Pharm in Drug Dev 2021;10:502
    https://doi.org/10.1002/cpdd.888
  239. Samaneh Soleymani, Roodabeh Bahramsoltani, Roja Rahimi, Mohammad Abdollahi. Clinical risks of St John’s Wort (Hypericum perforatum) co-administration. Expert Opinion on Drug Metabolism & Toxicology 2017;13:1047
    https://doi.org/10.1080/17425255.2017.1378342
  240. Andrea Canitano, Elisabetta Iessi, Enrico Pierluigi Spugnini, Cristina Federici, Stefano Fais. Proton pump inhibitors induce a caspase-independent antitumor effect against human multiple myeloma. Cancer Letters 2016;376:278
    https://doi.org/10.1016/j.canlet.2016.04.015
  241. Yunju Jo, Eunkyoung Park, Sang Bong Ahn, Young Kwan Jo, Byungkwan Son, Seong Hwan Kim, Young Sook Park, Hyo Jeong Kim. A Proton Pump Inhibitor's Effect on Bone Metabolism Mediated by Osteoclast Action in Old Age: A Prospective Randomized Study. Gut Liver 2015;9
    https://doi.org/10.5009/gnl14135
  242. Youssef Rouphael, Giampaolo Raimondi, Luigi Lucini, Petronia Carillo, Marios C. Kyriacou, Giuseppe Colla, Valerio Cirillo, Antonio Pannico, Christophe El-Nakhel, Stefania De Pascale. Physiological and Metabolic Responses Triggered by Omeprazole Improve Tomato Plant Tolerance to NaCl Stress. Front. Plant Sci. 2018;9
    https://doi.org/10.3389/fpls.2018.00249
  243. Maria Marinescu, Ludmila Otilia Cinteză, George Iuliu Marton, Mariana-Carmen Chifiriuc, Marcela Popa, Ioana Stănculescu, Christina-Marie Zălaru, Cristina-Elena Stavarache. Synthesis, density functional theory study and in vitro antimicrobial evaluation of new benzimidazole Mannich bases. BMC Chemistry 2020;14
    https://doi.org/10.1186/s13065-020-00697-z
  244. Banita Thakur, Laila Pamela Hasooni, Ruchi Gera, Sumonto Mitra, Lars Björndahl, Taher Darreh-Shori. Presence of key cholinergic enzymes in human spermatozoa and seminal fluid. 2024;110:63
    https://doi.org/10.1093/biolre/ioad127
  245. Yumeng Xiao, Wenwen Xu, Dandan Niu, Zhuowei Quan, Ling Wang. Investigation into the impact of proton pump inhibitors on sertraline transport across the blood-brain barrier. European Journal of Pharmaceutical Sciences 2024;194:106653
    https://doi.org/10.1016/j.ejps.2023.106653
  246. Precious Mathebela, Botle Precious Damane, Thanyani Victor Mulaudzi, Zilungile Lynette Mkhize-Khwitshana, Guy Roger Gaudji, Zodwa Dlamini. Influence of the Microbiome Metagenomics and Epigenomics on Gastric Cancer. IJMS 2022;23:13750
    https://doi.org/10.3390/ijms232213750
  247. Hyun Lim, Jong Kyu Park, Hyunsoo Chung, Si Hyung Lee, Jae Myung Park, Jung Ho Park, Gwang Ha Kim, Sung Kwan Shin, Su Jin Hong, Kwang Jae Lee, Moo In Park, Hye-Kyung Jung, Hyun-Soo Kim, Jae Kyu Sung, Seong Woo Jeon, Suck Chei Choi, Jeong Seop Moon, Nayoung Kim, Jong-Jae Park, Sung Hee Hong, Na Young Kim, Hwoon-Yong Jung. Efficacy and safety of HIP1601 (dual delayed-release esomeprazole) 40 mg in erosive esophagitis compared to HGP1705 (delayed-release esomeprazole) 40 mg: a multicenter, randomized, double-blind, non-inferiority study. BMC Gastroenterol 2023;23
    https://doi.org/10.1186/s12876-023-03087-6
  248. Yunjing He, Jingrui Zheng, Binbin Ye, Yongzhao Dai, Ke Nie. Chemotherapy-induced gastrointestinal toxicity: Pathogenesis and current management. Biochemical Pharmacology 2023;216:115787
    https://doi.org/10.1016/j.bcp.2023.115787
  249. Rajnish Kumar, Amit Kumar, Agneta Nordberg, Bengt Långström, Taher Darreh‐Shori. Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme—A plausible missing link for their association with incidence of dementia. Alzheimer's & Dementia 2020;16:1031
    https://doi.org/10.1002/alz.12113
  250. Saifur Rahman, Taufiq Rahman. Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway. Sci Rep 2017;7
    https://doi.org/10.1038/s41598-017-13343-x
  251. Zuber Khan, Sidharth Mehan, Mohd. Anas Saifi, Ghanshyam Das Gupta, Acharan S. Narula, Reni Kalfin. Proton Pump Inhibitors and Cognitive Health: Review on Unraveling the Dementia Connection and Co-morbid Risks. CAR 2023;20:739
    https://doi.org/10.2174/0115672050289946240223050737
  252. Julian Wolfes, Christian Ellermann, Sophie Burde, Patrick Leitz, Nils Bögeholz, Kevin Willy, Michael Fehr, Lars Eckardt, Gerrit Frommeyer. Concomitant Treatment with Proton Pump Inhibitors and Cephalosporins Does Not Enhance QT-Associated Proarrhythmia in Isolated Rabbit Hearts. Cardiovasc Toxicol 2020;20:531
    https://doi.org/10.1007/s12012-020-09577-3
  253. Liang Tian, Chongfei Huang, Wenkang Fu, Long Gao, Ningning Mi, Mingzhen Bai, Haidong Ma, Chao Zhang, Yawen Lu, Jinyu Zhao, Xianzhuo Zhang, Ningzu Jiang, Yanyan Lin, Ping Yue, Jinqiu Yuan, Wenbo Meng. Proton pump inhibitors may enhance the risk of digestive diseases by regulating intestinal microbiota. Front. Pharmacol. 2023;14
    https://doi.org/10.3389/fphar.2023.1217306
  254. Dawei Yu, Qingqing Zhang, Bram De Jaegher, Jibao Liu, Qianwen Sui, Xiang Zheng, Yuansong Wei. Effect of proton pump inhibitor on microbial community, function, and kinetics in anaerobic digestion with ammonia stress. Bioresource Technology 2021;319:124118
    https://doi.org/10.1016/j.biortech.2020.124118
  255. Jong‐Lyul Ghim, May Chien Chin, Jinah Jung, Jiwon Lee, Seokuee Kim, Bongtae Kim, Geun Seog Song, Young‐Kyung Choi, Jae‐Gook Shin. Pharmacokinetics and Pharmacodynamics of Tegoprazan Coadministered With Amoxicillin and Clarithromycin in Healthy Subjects. The Journal of Clinical Pharma 2021;61:913
    https://doi.org/10.1002/jcph.1805
  256. Shuvo Mitra, Md. Saddam Hussain, Rubiya Rahman, Md. Abdus Salam, Tanoy Mazumder, Sarmin Farzana. A survey on the incidence of common musculoskeletal side effects among the patients taking long-term anti-ulcerant therapies in Bangladesh. Toxicology Reports 2022;9:1796
    https://doi.org/10.1016/j.toxrep.2022.09.007
  257. Nobuhiro Inatomi, Jun Matsukawa, Yuuichi Sakurai, Kazuyoshi Otake. Potassium-competitive acid blockers: Advanced therapeutic option for acid-related diseases. Pharmacology & Therapeutics 2016;168:12
    https://doi.org/10.1016/j.pharmthera.2016.08.001
  258. Man Yu, Carol Lee, Marina Wang, Ian F. Tannock. Influence of the proton pump inhibitor lansoprazole on distribution and activity of doxorubicin in solid tumors. Cancer Science 2015;106:1438
    https://doi.org/10.1111/cas.12756
  259. Shu-Kai Zhan, Xiao-Qin Wu, Feng-Ping Zheng, Fabiana Zingone. Clinical Characteristics and Manifestations of Fungal Esophagitis: A Single-Center Experience in South China. Gastroenterology Research and Practice 2021;2021:1
    https://doi.org/10.1155/2021/8869494
  260. Michael Kukulka, Sai Nudurupati, Maria Claudia Perez. Bioavailability, safety, and pharmacodynamics of delayed-release dexlansoprazole administered as two 30 mg orally disintegrating tablets or one 60 mg capsule. Therap Adv Gastroenterol 2016;9:770
    https://doi.org/10.1177/1756283X16666800
  261. Lars-Olav Harnisch, Jürgen Brockmöller, Anne Hapke, Juliane Sindern, Ellen Bruns, Ruben Evertz, Karl Toischer, Bernhard C. Danner, Dorothee Mielke, Veit Rohde, Tammam Abboud. Oral Drug Absorption and Drug Disposition in Critically Ill Cardiac Patients. Pharmaceutics 2023;15:2598
    https://doi.org/10.3390/pharmaceutics15112598
  262. Yusmiati Yusmiati, Dewi Muliaty. The Pharmacogenetics of Cytochrome P450 2C19 Enzymes - Effects on Clopidogrel and Proton Pump Inhibitors. Indones Biomed J 2014;6:33
    https://doi.org/10.18585/inabj.v6i1.41
  263. Margaret Slavin, Cara L. Frankenfeld, Alexander B. Guirguis, Elizabeth K. Seng. Use of Acid-Suppression Therapy and Odds of Migraine and Severe Headache in the National Health and Nutrition Examination Survey. Neur Clin Pract 2024;14
    https://doi.org/10.1212/CPJ.0000000000200302
  264. S. Sobrino-Cossío, O. Teramoto-Matsubara, G. Mateos-Pérez, J.M. Abdo-Francis, J. Tawil, C. Olguín-Ramírez, A. Orozco-Gamiz, E.S. Galvis-García. La búsqueda del Grial: una carrera por la supresión ácida. Revista de Gastroenterología de México 2019;84:344
    https://doi.org/10.1016/j.rgmx.2019.04.002
  265. Jonathan Leis, Chi-Hao Luan, James E. Audia, Sara F. Dunne, Carissa M. Heath, Jae U. Jung. Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells. J Virol 2021;95
    https://doi.org/10.1128/JVI.00190-21
  266. Inès Ben Ghezala, Maxime Luu, Marc Bardou. An update on drug–drug interactions associated with proton pump inhibitors. Expert Opinion on Drug Metabolism & Toxicology 2022;18:337
    https://doi.org/10.1080/17425255.2022.2098107