Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Cited by CrossRef (170)

  1. James S. Martin, Claire J. MacKenzie, Daniel Fletcher, Ian H. Gilbert. Characterising covalent warhead reactivity. Bioorganic & Medicinal Chemistry 2019;27:2066
    https://doi.org/10.1016/j.bmc.2019.04.002
  2. Andy Liu, Bellal Jubran, Emeka K. Enwere, Megan Hansen, Nicole E. Burma, Yasmin Nasser. Encyclopedia of Gastroenterology. 2019.
    https://doi.org/10.1016/B978-0-12-801238-3.65617-9
  3. Abdrrahman Shemsu Surur, Lukas Schulig, Andreas Link. Interconnection of sulfides and sulfoxides in medicinal chemistry. Arch. Pharm. Chem. Life Sci. 2018:1800248
    https://doi.org/10.1002/ardp.201800248
  4. Dongyang Liu, Hong Yang, Ji Jiang, Péter Nagy, Kai Shen, Jiaming Qian, Pei Hu. Pharmacokinetic and Pharmacodynamic Modeling Analysis of Intravenous Esomeprazole in Healthy Volunteers. The Journal of Clinical Pharmacology 2016;56:816
    https://doi.org/10.1002/jcph.733
  5. Yang Won Min, Yeong Chan Lee, Kyunga Kim, Seungho Ryu, Kyoung Sub Hong, Han Ho Jeon, Yong Sung Kim, Jong Heon Park, Hee Jung Son, Poong-Lyul Rhee. Proton pump inhibitor use is associated with hip fracture development: a nationwide population-based cohort study . Korean J Intern Med 2020;35:1084
    https://doi.org/10.3904/kjim.2018.331
  6. Hyunsoo Kim, Yoon Soo Hwang, Mingi Kim, Seung Bum Park. Recent advances in the development of covalent inhibitors. RSC Med. Chem. 2021;12:1037
    https://doi.org/10.1039/D1MD00068C
  7. Young Dal Lee, Sung Eun Kim, Seun Ja Park, Moo In Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung, Jiyun Song. Efficacy of Seven-day High-dose Esomeprazole-based Triple Therapy versus Seven-day Standard Dose Non-esomeprazole-based Triple Therapy as the First-line Treatment of Patients with Helicobacter pylori Infection. Korean J Gastroenterol 2020;76:142
    https://doi.org/10.4166/kjg.2020.76.3.142
  8. M. Serratice, B. Bertrand, E. F. J. Janssen, E. Hemelt, A. Zucca, F. Cocco, M. A. Cinellu, A. Casini. Gold(i) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro. Med. Chem. Commun. 2014;5:1418
    https://doi.org/10.1039/C4MD00241E
  9. Hideki Mori, Hidekazu Suzuki. Role of Acid Suppression in Acid-related Diseases: Proton Pump Inhibitor and Potassium-competitive Acid Blocker. J Neurogastroenterol Motil 2019;25:6
    https://doi.org/10.5056/jnm18139
  10. Hee Jin Kim, Nayoung Kim, Ji Hyun Park, Sunkyu Choi, Cheol Min Shin, Ok Jae Lee. Helicobacter pylori Eradication Induced Constant Decrease in Interleukin- 1B Expression over More Than 5 Years in Patients with Gastric Cancer and Dysplasia. Gut and Liver 2020;14:735
    https://doi.org/10.5009/gnl19312
  11. Avik Ray, Swati Sharma, Balakrishnan Sadasivam. The Potential Therapeutic Role of Proton Pump Inhibitors in COVID-19: Hypotheses Based on Existing Evidences. Drug Res (Stuttg) 2020;70:484
    https://doi.org/10.1055/a-1236-3041
  12. Ranran Jia, Fan Zhang, Ni Wu, Wen Xu, Huitao Gao, Bo Liu, Hongyun Wang. Accelerating Development of Benziamidazole-Class Proton Pump Inhibitors: A Mechanism-Based PK/PD Model to Optimize Study Design with Ilaprazole as a Case Drug. Pharmaceutics 2021;13:392
    https://doi.org/10.3390/pharmaceutics13030392
  13. Jin-Young Min, Christopher J. Ocampo, Whitney W. Stevens, Caroline P.E. Price, Christopher F. Thompson, Tetsuya Homma, Julia H. Huang, James E. Norton, Lydia A. Suh, Kathryn L. Pothoven, David B. Conley, Kevin C. Welch, Stephanie Shintani-Smith, Anju T. Peters, Leslie C. Grammer, Kathleen E. Harris, Kathryn E. Hulse, Atsushi Kato, Nikolai N. Modyanov, Robert C. Kern, Robert P. Schleimer, Bruce K. Tan. Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric H,K-ATPase. Journal of Allergy and Clinical Immunology 2017;139:130
    https://doi.org/10.1016/j.jaci.2016.07.020
  14. Craig M. Lilly, Mohammad Aljawadi, Omar Badawi, Ebere Onukwugha, Sarah E. Tom, Laurence S. Magder, Ilene Harris. Comparative Effectiveness of Proton Pump Inhibitors vs Histamine Type 2 Receptor Blockers for Preventing Clinically Important Gastrointestinal Bleeding During Intensive Care. Chest 2018;154:557
    https://doi.org/10.1016/j.chest.2018.05.015
  15. Akiko Shiotani, Ryo Katsumata, Kyousuke  Gouda, Shinya Fukushima, Rui Nakato, Takahisa Murao, Manabu Ishii, Minoru Fujita, Hiroshi Matsumoto, Takashi Sakakibara. Hypergastrinemia in Long-Term Use of Proton Pump Inhibitors. Digestion 2018;97:154
    https://doi.org/10.1159/000484688
  16. King-Wah Chiu, Toshiaki Nakano, Kuang-Den Chen, Li-Wen Hsu, Chia-Yun Lai, Ching-Yin Huang, Yu-Fan Cheng, Shigeru Goto, Chao-Long Chen. Cytochrome P450 in living donor liver transplantation. J Biomed Sci 2015;22
    https://doi.org/10.1186/s12929-015-0140-4
  17. Hariharan Sivaraman, Shi Yin Er, Yeu Khai Choong, Edem Gavor, J. Sivaraman. Structural Basis of SARS-CoV-2– and SARS-CoV–Receptor Binding and Small-Molecule Blockers as Potential Therapeutics. Annu. Rev. Pharmacol. Toxicol. 2021;61:465
    https://doi.org/10.1146/annurev-pharmtox-061220-093932
  18. Boriana K. Tchernookova, Michael W. Gongwer, Alexis George, Brock Goeglein, Alyssa M. Powell, Hannah L. Caringal, Thomas Leuschner, Anna G. Phillips, Adam W. Schantz, Lech Kiedrowski, Richard Chappell, Matthew A. Kreitzer, Robert Paul Malchow. ATP-mediated increase in H+ flux from retinal Müller cells: a role for Na+/H+ exchange. Journal of Neurophysiology 2021;125:184
    https://doi.org/10.1152/jn.00546.2020
  19. Cynthia Kanagaratham, Yasmeen S. El Ansari, Benjamin F. Sallis, Brianna-Marie A. Hollister, Owen L. Lewis, Samantha C. Minnicozzi, Michiko K. Oyoshi, Rachel Rosen, Samuel Nurko, Edda Fiebiger, Hans C. Oettgen. Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice. Journal of Allergy and Clinical Immunology 2020;146:884
    https://doi.org/10.1016/j.jaci.2020.02.032
  20. Luana Lugini, Cristina Federici, Martina Borghi, Tommaso Azzarito, Maria Lucia Marino, Albino Cesolini, Enrico Pierluigi Spugnini, Stefano Fais. Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect. Journal of Enzyme Inhibition and Medicinal Chemistry 2016;31:538
    https://doi.org/10.3109/14756366.2015.1046062
  21. Tadayuki Oshima, Hiroto Miwa. Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases. J Neurogastroenterol Motil 2018;24:334
    https://doi.org/10.5056/jnm18029
  22. Longgang Niu, Yu Liu, Xiaomin Hou, Lijuan Cui, Jiangtao Li, Xuanping Zhang, Mingsheng Zhang. Extracellular acidosis contracts coronary but neither renal nor mesenteric artery via modulation of H+,K+-ATPase, voltage-gated K+channels and L-type Ca2+channels. Exp Physiol 2014;99:995
    https://doi.org/10.1113/expphysiol.2014.078634
  23. Sung-Hwa Sohn, Nayoung Kim, Hyun Jin Jo, Jaeyeon Kim, Ji Hyun Park, Ryoung Hee Nam, Yeong-Jae Seok, Yeon-Ran Kim, Dong Ho Lee. Analysis of Gastric Body Microbiota by Pyrosequencing: Possible Role of Bacteria Other ThanHelicobacter pyloriin the Gastric Carcinogenesis. J Cancer Prev 2017;22:115
    https://doi.org/10.15430/JCP.2017.22.2.115
  24. V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, O. A. Storonova, O. V. Zayratyants, O. B. Dronova, Yu. A. Kucheryavyy, S. S. Pirogov, R. G. Sayfutdinov, Yu. P. Uspenskiy, A. A. Sheptulin, D. N. Andreev, D. E. Rumyantseva. Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease. Rossijskij žurnal gastroènterologii, gepatologii, koloproktologii 2020;30:70
    https://doi.org/10.22416/1382-4376-2020-30-4-70-97
  25. Valentina Shakhnovich, P. Brian Smith, Jeffrey T. Guptill, Laura P. James, David N. Collier, Huali Wu, Chad E. Livingston, Jian Zhao, Gregory L. Kearns, Daniel K. Benjamin, Katherine Y. Berezny, P. Michael Cohen Wolkowiez, Matthew M. Laughon, Ian M. Paul, Michael J. Smith, John van den Anker, Kelly Wade, David Siegel, Perdita Taylor-Zapata, Anne Zajicek, Zhaoxia Ren, Ekaterini Tsilou, Alice Pagan, Ravinder Anand, Traci Clemons, Gina Simone, Lee Howard, Jaylene Weigel, Nancy Darden Saad. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures. The Journal of Pediatrics 2018;193:102
    https://doi.org/10.1016/j.jpeds.2017.10.011
  26. Yuli Guzman-Prado, Roberto Vita, Ondrej Samson. Concomitant Use of Levothyroxine and Proton Pump Inhibitors in Patients with Primary Hypothyroidism: a Systematic Review. J GEN INTERN MED 2021;36:1726
    https://doi.org/10.1007/s11606-020-06403-y
  27. Mustafa Abdul-Hussein, Janice Freeman, Donald Castell. Concomitant Administration of a Histamine2 Receptor Antagonist and Proton Pump Inhibitor Enhances Gastric Acid Suppression. Pharmacotherapy 2015;35:1124
    https://doi.org/10.1002/phar.1665
  28. Yi Song, Fengna Dou, Zhe Zhou, Ningmin Yang, Jing Zhong, Jie Pan, Qiqi Liu, Jianzhong Zhang, Shengqi Wang. Microarray-Based Detection and Clinical Evaluation for Helicobacter pylori Resistance to Clarithromycin or Levofloxacin and the Genotype of CYP2C19 in 1083 Patients. BioMed Research International 2018;2018:1
    https://doi.org/10.1155/2018/2684836
  29. Mario Nagase, Hitoshi Shimada, Masahiro Nii, Shinya Ueda, Mitsuo Higashimori, Katsuomi Ichikawa, Li Zhang, Li Zhou, Yingxue Chen, Diansong Zhou, James Dunyak, Nidal Al‐Huniti. Population pharmacokinetic analysis of esomeprazole in Japanese subjects with various CYP2C19 phenotypes. J Clin Pharm Ther 2020;45:1030
    https://doi.org/10.1111/jcpt.13129
  30. Jumpei Saito, Naho Yakuwa, Noriko Sandaiji, Hiroyo Kawasaki, Kayoko Kaneko, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Atsuko Murashima. Esomeprazole During Pregnancy and Lactation: Esomeprazole Levels in Maternal Serum, Cord Blood, Breast Milk, and the Infant's Serum. Breastfeeding Medicine 2020;15:598
    https://doi.org/10.1089/bfm.2020.0175
  31. Johan Gabrielsson, Stephan Hjorth. Early Drug Development. 2020.
    https://doi.org/10.1002/9783527801756.ch14
  32. Ankit Namdev, Dharmendra Jain. Floating Drug Delivery Systems: An Emerging Trend for the Treatment of Peptic Ulcer. CDD 2019;16:874
    https://doi.org/10.2174/1567201816666191018163519
  33. Olena Kis, Sharon L. Walmsley, Reina Bendayan. In Vitro and In Situ Evaluation of pH-Dependence of Atazanavir Intestinal Permeability and Interactions with Acid-Reducing Agents. Pharm Res 2014;31:2404
    https://doi.org/10.1007/s11095-014-1336-0
  34. Hsun Yang, Shiun-Yang Juang, Kuan-Fu Liao. Proton pump inhibitors use and risk of chronic kidney disease in diabetic patients. Diabetes Research and Clinical Practice 2019;147:67
    https://doi.org/10.1016/j.diabres.2018.11.019
  35. Mahdieh Darroudi, Ghodsi Mohammadi Ziarani, Shahriyar Bahar, Jahan B. Ghasemi, Alireza Badiei. Lansoprazole-Based Colorimetric Chemosensor for Efficient Binding and Sensing of Carbonate Ion: Spectroscopy and DFT Studies. Front. Chem. 2021;8
    https://doi.org/10.3389/fchem.2020.626472
  36. Laurent Soulère, Thibaut Barbier, Yves Queneau. Docking-based virtual screening studies aiming at the covalent inhibition of SARS-CoV-2 MPro by targeting the cysteine 145. Computational Biology and Chemistry 2021;92:107463
    https://doi.org/10.1016/j.compbiolchem.2021.107463
  37. Helgadottir, Bjornsson. Problems Associated with Deprescribing of Proton Pump Inhibitors. IJMS 2019;20:5469
    https://doi.org/10.3390/ijms20215469
  38. Yugo Hamada, Kenji Ikemura, Takuya Iwamoto, Masahiro Okuda. Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers. Pharmacology 2018;101:176
    https://doi.org/10.1159/000485920
  39. Dragos Apostu, Ondine Lucaciu, Gheorghe Dan Osvald Lucaciu, Bogdan Crisan, Liana Crisan, Mihaela Baciut, Florin Onisor, Grigore Baciut, Radu Septimiu Câmpian, Simion Bran. Systemic drugs that influence titanium implant osseointegration. Drug Metabolism Reviews 2017;49:92
    https://doi.org/10.1080/03602532.2016.1277737
  40. Timothy P. Shiraev, Andrew Bullen. Proton Pump Inhibitors and Cardiovascular Events: A Systematic Review. Heart, Lung and Circulation 2018;27:443
    https://doi.org/10.1016/j.hlc.2017.10.020
  41. Jessica Escoffier, Bastien Arnaud, Mayis Kaba, Jean Pascal Hograindleur, Emilie Le Blévec, Guillaume Martinez, Isabelle Stévant, Pierre F. Ray, Christophe Arnoult, Serge Nef. Pantoprazole, a proton‐pump inhibitor, impairs human sperm motility and capacitation in vitro. Andrologia 2020;8:1795
    https://doi.org/10.1111/andr.12855
  42. Xiaoxiao Yang, Yueyue Li, Yiyuan Sun, Mingming Zhang, Chuanguo Guo, Iqtida Ahmed Mirza, Yan-Qing Li. Vonoprazan: A Novel and Potent Alternative in the Treatment of Acid-Related Diseases. Dig Dis Sci 2018;63:302
    https://doi.org/10.1007/s10620-017-4866-6
  43. Carine Franco Morschel, Denise Mafra, José Carlos Carraro Eduardo. The relationship between proton pump inhibitors and renal disease. J. Bras. Nefrol. 2018;40:301
    https://doi.org/10.1590/2175-8239-jbn-2018-0021
  44. Saswati Bhattacharya, Jasmina Khanam, Pradipta Sarkar, Tapan Kumar Pal. A chemotherapeutic approach targeting the acidic tumor microenvironment: combination of a proton pump inhibitor and paclitaxel for statistically optimized nanotherapeutics. RSC Adv. 2019;9:240
    https://doi.org/10.1039/C8RA08924H
  45. Vincent H Ha, Margaret Ngo, Michael P Chu, Sunita Ghosh, Michael B Sawyer, Carole R Chambers. Does gastric acid suppression affect sunitinib efficacy in patients with advanced or metastatic renal cell cancer?. J Oncol Pharm Pract 2015;21:194
    https://doi.org/10.1177/1078155214527145
  46. Mohamed S. AbdElhalim, Ahmed S. Kenawy, Heba H. El Demellawy, Amany A. Azouz, Sarah S. Alghanem, Torki Al-Otaibi, Osama Gheith, Mohamed Abd ElMonem, Mohammed K. Afifi, Raghda R. S. Hussein. The impact of omeprazole on mycophenolate pharmacokinetics in kidney transplant recipients. Kidney Res Clin Pract 2020;39:479
    https://doi.org/10.23876/j.krcp.20.059
  47. Mitsuhiro Tachibana, Tomohiko Hanaoka, Shinya Watanabe, Masahiro Matsushita, Tadahiro Isono, Yutaka Tsutsumi. Colitis nucleomigrans: The third type of microscopic colitis (part 1). Pathology International 2020;70:752
    https://doi.org/10.1111/pin.12996
  48. Adila Salih ElObeid, Adil Haseeb. Treating ENT symptoms and diseases induced by extraesophageal acidity using plant extracted melanin. Medical Hypotheses 2020;144:110126
    https://doi.org/10.1016/j.mehy.2020.110126
  49. David B. Stewart, John P. Hegarty. Correlation between virulence gene expression and proton pump inhibitors and ambient pH in Clostridium difficile: results of an in vitro study. 2013;62:1517
    https://doi.org/10.1099/jmm.0.059709-0
  50. S. Šutalo, M. Ruetten, S. Hartnack, C.E. Reusch, P. H. Kook. The Effect of Orally Administered Ranitidine and Once-Daily or Twice-Daily Orally Administered Omeprazole on Intragastric pH in Cats. J Vet Intern Med 2015;29:840
    https://doi.org/10.1111/jvim.12580
  51. Chuan Tian, Lixin Zhu, Dan Yu, Zhiwei Cao, Tingguo Kang, Ruixin Zhu. The Stereoselectivity of CYP2C19 on R- and S-isomers of Proton Pump Inhibitors. Chem Biol Drug Des 2014;83:610
    https://doi.org/10.1111/cbdd.12274
  52. Megan Walsh, Stefano Fais, Enrico Pierluigi Spugnini, Salvador Harguindey, Tareq Abu Izneid, Licia Scacco, Paula Williams, Cinzia Allegrucci, Cyril Rauch, Ziad Omran. Proton pump inhibitors for the treatment of cancer in companion animals. J Exp Clin Cancer Res 2015;34
    https://doi.org/10.1186/s13046-015-0204-z
  53. G. Sachs, E. A. Marcus, Y. Wen, K. Munson. Editorial: control of acid secretion. Aliment Pharmacol Ther 2018;48:682
    https://doi.org/10.1111/apt.14864
  54. Ryoko Toda, Tomoharu Miyagawa, Yuka Masuda, Yusuke Hoshino, Kazuyoshi Yoshii, Masamichi Hirayama, Minaka Shibuya, Yoshihiro Kawabata. Mass balance and metabolism of Z-215, a novel proton pump inhibitor, in healthy volunteers. Xenobiotica 2018;48:1006
    https://doi.org/10.1080/00498254.2017.1390625
  55. Carlos Arturo Rojas, Mario Sepúlveda Copete, Jairo Alberto García Abadía, Héctor Raúl Echavarría Abad, Fernando Rosso Suárez, Andrés Fernando Jiménez, Andrés Mauricio Castro Llanos. Un ensayo clínico piloto de la efectividad clínica de dos presentaciones de esomeprazol . Rev Colomb Gastroenterol 2019;34:261
    https://doi.org/10.22516/25007440.335
  56. Cheol Min Shin. Alternations of Gastric Microbiota with Mucosal Atrophy and Intestinal Metaplasia. Korean J Helicobacter Up Gastrointest Res 2020;20:187
    https://doi.org/10.7704/kjhugr.2020.0037
  57. Mohammed M Mehanna, Amina Tarek Mneimneh, Souraya Domiati, Ahmed N Allam.

    Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity

    . IJN 2020;Volume 15:10099
    https://doi.org/10.2147/IJN.S288552
  58. Hashem Ahmadizadegan, Mahdi Ranjbar, Sheida Esmaielzadeh. Synthesis and characterization of green membranes polyimide/titania bionanocomposites containing amino acid and benzimidazole moieties for gas transport properties. Polym Eng Sci 2018;58:1666
    https://doi.org/10.1002/pen.24757
  59. Hua‐Ching Chang, Yin‐Shuo Chang, Kuo‐Hsien Wang, Tiong Cheng, Hsiou‐Hsin Tsai. Esomeprazole‐induced ashy dermatosis‐like drug eruptions. Australas J Dermatol 2019;60
    https://doi.org/10.1111/ajd.12978
  60. J.M. Remes-Troche, F.D. García García, G. Rojas-Loureiro, X. Rivera-Gutiérrez, J. Reyes-Huerta, M. Amieva-Balmori. Efecto sobre el pH intragástrico de 20 mg de levopantoprazol versus 40 mg de pantoprazol racémico durante los primeros 7 días de tratamiento en pacientes con enfermedad por reflujo gastroesofágico. Revista de Gastroenterología de México 2020;85:48
    https://doi.org/10.1016/j.rgmx.2019.02.006
  61. Michael Burger, Caroline Schmitt-Koopmann, Jean-Christophe Leroux. DNA unchained: two assays to discover and study inhibitors of the DNA clustering function of barrier-to-autointegration factor. Sci Rep 2020;10
    https://doi.org/10.1038/s41598-020-69246-x
  62. Annamaria Tonazzi, Ivano Eberini, Cesare Indiveri, Gabriele Vincenzo Gnoni. Molecular Mechanism of Inhibition of the Mitochondrial Carnitine/Acylcarnitine Transporter by Omeprazole Revealed by Proteoliposome Assay, Mutagenesis and Bioinformatics. PLoS ONE 2013;8:e82286
    https://doi.org/10.1371/journal.pone.0082286
  63. Philip Woodland, Gehanjali Amarasinghe, Daniel Sifrim. Emerging therapeutic options in GERD. Best Practice & Research Clinical Gastroenterology 2013;27:455
    https://doi.org/10.1016/j.bpg.2013.06.006
  64. Tatjana Bosnjak, Rigmor Solberg, Paya Diana Hemati, Abbas Jafari, Moustapha Kassem, Harald Thidemann Johansen. Lansoprazole inhibits the cysteine protease legumain by binding to the active site. Basic Clin Pharmacol Toxicol 2019
    https://doi.org/10.1111/bcpt.13230
  65. Gautham Yepuri, Roman Sukhovershin, Timo Z. Nazari-Shafti, Michael Petrascheck, Yohannes T. Ghebre, John P. Cooke. Proton Pump Inhibitors Accelerate Endothelial Senescence. Circ Res 2016;118
    https://doi.org/10.1161/CIRCRESAHA.116.308807
  66. Yoon Jin Choi, Nayoung Kim, In-Jin Jang, Joo-Youn Cho, Ryoung Hee Nam, Ji Hyun Park, Hyun Jin Jo, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Hyun Chae Jung. Pantoprazole Does Not Reduce the Antiplatelet Effect of Clopidogrel: A Randomized Controlled Trial in Korea. Gut and Liver 2017;11:504
    https://doi.org/10.5009/gnl16352
  67. Madeleine Strickland, Lorna S. Ehrlich, Susan Watanabe, Mahfuz Khan, Marie-Paule Strub, Chi-Hao Luan, Michael D. Powell, Jonathan Leis, Nico Tjandra, Carol A. Carter. Tsg101 chaperone function revealed by HIV-1 assembly inhibitors. Nat Commun 2017;8
    https://doi.org/10.1038/s41467-017-01426-2
  68. Hsiu-Chen Lin, Yu-Ting Hsiao, Hsiu-Li Lin, Yow-Shieng Uang, Hui-Wen Cheng, Ying Wang, Li-Hsuan Wang. The use of proton pump inhibitors decreases the risk of diabetes mellitus in patients with upper gastrointestinal disease. 2016;95:e4195
    https://doi.org/10.1097/MD.0000000000004195
  69. Ning-Ning Liu, Julia R. Köhler. Antagonism of Fluconazole and a Proton Pump Inhibitor against Candida albicans. Antimicrob Agents Chemother 2016;60:1145
    https://doi.org/10.1128/AAC.02043-15
  70. Alexandru Mester, Dragos Apostu, Lidia Ciobanu, Andra Piciu, Ondine Lucaciu, Radu Septimiu Campian, Marian Taulescu, Simion Bran. The impact of proton pump inhibitors on bone regeneration and implant osseointegration. Drug Metabolism Reviews 2019;51:330
    https://doi.org/10.1080/03602532.2019.1610767
  71. Negar Kanounisabet, Ahmad Mogharehabed, Nakisa Torabinia, SeyedehMarzieh Hashemi Nejad, Jaber Yaghini. Effect of systemic administration of omeprazole on osseointegration around titanium dental implants: A histomorphometric study in dogs. Dent Res J 2021;18:43
    https://doi.org/10.4103/1735-3327.318938
  72. Xiaoxia Zhao, Ning Zhang, Yingying Huang, Xiaojing Dou, Xiaolin Peng, Wei Wang, Zhe Zhang, Ran Wang, Yuling Qiu, Meihua Jin, Dexin Kong. Lansoprazole Alone or in Combination With Gefitinib Shows Antitumor Activity Against Non-small Cell Lung Cancer A549 Cells in vitro and in vivo. Front. Cell Dev. Biol. 2021;9
    https://doi.org/10.3389/fcell.2021.655559
  73. BYUNG KIL CHOO, SEONG-SOO ROH. Berberine protects against esophageal mucosal damage in reflux esophagitis by suppressing proinflammatory cytokines. 2013;6:663
    https://doi.org/10.3892/etm.2013.1202
  74. Tanzila Arshad, Khalid Mohammed Khan, Najma Rasool, Uzma Salar, Shafqat Hussain, Humna Asghar, Mohammed Ashraf, Abdul Wadood, Muhammad Riaz, Shahnaz Perveen, Muhammad Taha, Nor Hadiani Ismail. 5-Bromo-2-aryl benzimidazole derivatives as non-cytotoxic potential dual inhibitors of α -glucosidase and urease enzymes. Bioorganic Chemistry 2017;72:21
    https://doi.org/10.1016/j.bioorg.2017.03.007
  75. Tigran Makunts, Isaac V. Cohen, Linda Awdishu, Ruben Abagyan. Analysis of postmarketing safety data for proton-pump inhibitors reveals increased propensity for renal injury, electrolyte abnormalities, and nephrolithiasis. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-39335-7
  76. Hao Wang, Yantong Sun, Yan Yang, Wei Guo, Mi Zheng, Weiping Zhang, J Paul Fawcett, Jingkai Gu. Application of a high-throughput, parallel HPLC system for quantitative chiral analysis of pantoprazole. Bioanalysis 2015;7:2981
    https://doi.org/10.4155/bio.15.215
  77. M. Srinivas, S. Satyaveni, B. Ram. Synthesis and Anticancer Activity of 1,2,4-Oxadiazol Linked Benzimidazole Derivatives. Russ J Gen Chem 2018;88:2653
    https://doi.org/10.1134/S1070363218120289
  78. Chongzhuang Tang, Zhaoqiang Chen, Xiaojian Dai, Weiliang Zhu, Dafang Zhong, Xiaoyan Chen. Mechanism of Reductive Metabolism and Chiral Inversion of Proton Pump Inhibitors. Drug Metab Dispos 2019;47:657
    https://doi.org/10.1124/dmd.118.086090
  79. Sara Granja, Diana Tavares-Valente, Odília Queirós, Fátima Baltazar. Value of pH regulators in the diagnosis, prognosis and treatment of cancer. Seminars in Cancer Biology 2017;43:17
    https://doi.org/10.1016/j.semcancer.2016.12.003
  80. Kentaro Sugano. Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date. Therap Adv Gastroenterol 2018;11:1756283X1774577
    https://doi.org/10.1177/1756283X17745776
  81. S Setiadji, C D D Sundari, M A Ramdhani, A B K Umam, A L Ivansyah. Theoretical Investigation of Inclusion Complex between Omeprazole Enantiomers and Carboxymethyl-β-Cyclodextrin. IOP Conf. Ser.: Mater. Sci. Eng. 2018;288:012138
    https://doi.org/10.1088/1757-899X/288/1/012138
  82. Ran Li, Xiaoyun Chai, Xiaoyan Cui, Yuanying Jiang, Dazhi Zhang, Ting Wang. A fluorescence resonance energy transfer based pH probe for visualizing acidification in fungal cells. Sensors and Actuators B: Chemical 2018;274:533
    https://doi.org/10.1016/j.snb.2018.07.134
  83. Filippo Basagni, Michela Rosini, Michael Decker. Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes. ChemMedChem 2020;15:1374
    https://doi.org/10.1002/cmdc.202000298
  84. Dawei Yu, Tuo Wang, Yushuai Liang, Jibao Liu, Jiaxi Zheng, Meixue Chen, Yuansong Wei. Delivery and effects of proton pump inhibitor on anaerobic digestion of food and kitchen waste under ammonia stress. Journal of Hazardous Materials 2021;416:126211
    https://doi.org/10.1016/j.jhazmat.2021.126211
  85. J. P. Moraes-Filho, M. Pedroso, E. M. M. Quigley. Randomised clinical trial: daily pantoprazole magnesium 40 mg vs. esomeprazole 40 mg for gastro-oesophageal reflux disease, assessed by endoscopy and symptoms. Aliment Pharmacol Ther 2014;39:47
    https://doi.org/10.1111/apt.12540
  86. Madeleine Strickland, David Nyenhuis, Susan M. Watanabe, Nico Tjandra, Carol A. Carter. Novel Tsg101 Binding Partners Regulate Viral L Domain Trafficking. Viruses 2021;13:1147
    https://doi.org/10.3390/v13061147
  87. Susan M. Watanabe, Lorna S. Ehrlich, Madeleine Strickland, Xiaofan Li, Veronica Soloveva, Arthur J. Goff, Charles B. Stauft, Sumita Bhaduri-McIntosh, Nico Tjandra, Carol Carter. Selective Targeting of Virus Replication by Proton Pump Inhibitors. Sci Rep 2020;10
    https://doi.org/10.1038/s41598-020-60544-y
  88. S. Tommasi, D. J. Elliot, J. A. Hulin, B. C. Lewis, M. McEvoy, A. A. Mangoni. Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance. Sci Rep 2017;7
    https://doi.org/10.1038/s41598-017-03069-1
  89. Óskar Ö. Hálfdánarson, Katja Fall, Margret H. Ogmundsdottir, Sigrún H. Lund, Eiríkur Steingrímsson, Helga M. Ogmundsdottir, Helga Zoega. Proton pump inhibitor use and risk of breast cancer, prostate cancer, and malignant melanoma: An Icelandic population‐based case‐control study. Pharmacoepidemiol Drug Saf 2019;28:471
    https://doi.org/10.1002/pds.4702
  90. Yvonne Y. Lau, Wen Gu, Tiffany Lin, Kalyanee Viraswami-Appanna, Can Cai, Jeffrey W. Scott, Michael Shi. Assessment of drug–drug interaction potential between ceritinib and proton pump inhibitors in healthy subjects and in patients with ALK-positive non-small cell lung cancer. Cancer Chemother Pharmacol 2017;79:1119
    https://doi.org/10.1007/s00280-017-3308-7
  91. Prakash Bhaskar, Vasantha Kumar, Suresha Kumara Tholappanavara Hanumanthappa, Sowmya Haliwana Banakara Vijaykumar. 2-(3,4-Dimethoxyphenyl)-N-(4-methoxyphenyl)-1-propyl-1H-benzo[d]imidazole-5-carboxamide. Molbank 2019;2019:M1079
    https://doi.org/10.3390/M1079
  92. Gaurav Taneja, Punniyakoti V. Thanikachalam, Satyendra K. Rajput. Dose and time-dependent toxicological impact of pantoprazole on vascular endothelium and renal tissue. Toxicology Letters 2020;333:97
    https://doi.org/10.1016/j.toxlet.2020.07.031
  93. Nayoung Kim, Yoon Jin Choi. Helicobacter pylori. 2020.
    https://doi.org/10.1007/978-981-287-706-2_4
  94. Yingxi Chen, Bette Liu, Kathryn Glass, Wei Du, Emily Banks, Martyn Kirk, John Green. Use of Proton Pump Inhibitors and the Risk of Hospitalization for Infectious Gastroenteritis. PLoS ONE 2016;11:e0168618
    https://doi.org/10.1371/journal.pone.0168618
  95. Caroline Race, Joanna Chowdry, Jean M. Russell, Bernard M. Corfe, Stuart A. Riley. Studies of salivary pepsin in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2019;49:1173
    https://doi.org/10.1111/apt.15138
  96. Davide Cucchi, Alessandra Menon, Francesca Maria Feroldi, Linda Boerci, Pietro Simone Randelli. The presence of gastroesophageal reflux disease increases the risk of developing postoperative shoulder stiffness after arthroscopic rotator cuff repair. Journal of Shoulder and Elbow Surgery 2020;29:2505
    https://doi.org/10.1016/j.jse.2020.07.002
  97. Helena Emery, Tariq M. Butt, Christopher J. Coates. Nutraceutical intervention protects against bacterial and chemical-induced gastrotoxicity in a non-mammalian model, Galleria mellonella. Food and Chemical Toxicology 2021;154:112354
    https://doi.org/10.1016/j.fct.2021.112354
  98. Young Kwang Shim, Nayoung Kim. The Effect of H2Receptor Antagonist in Acid Inhibition and Its Clinical Efficacy. Korean J Gastroenterol 2017;70:4
    https://doi.org/10.4166/kjg.2017.70.1.4
  99. Flávia Almeida Santos, Vietla Satyanarayana Rao. Sistema Digestório: Integração Básico-Clínica. 2017.
    https://doi.org/10.5151/9788580391893-23
  100. K. Renuka Prasad, Priyanka Chettri, N. A. Rajesh, A. Rathinaswamy, R. Padmanaban, T. M. Vijayakumar. Assessment of the risk of acute kidney injury associated with the use of pantoprazole and esomeprazole. Drugs Ther Perspect 2018;34:223
    https://doi.org/10.1007/s40267-018-0503-5
  101. Stefano Fais, Yoshinori Marunaka. The Acidic Microenvironment: Is It a Phenotype of All Cancers? A Focus on Multiple Myeloma and Some Analogies with Diabetes Mellitus. Cancers 2020;12:3226
    https://doi.org/10.3390/cancers12113226
  102. J.M. Remes-Troche, F.D. García García, G. Rojas-Loureiro, X. Rivera-Gutiérrez, J. Reyes-Huerta, M. Amieva-Balmori. Intragastric pH effect of 20 mg of levo-pantoprazole versus 40 mg of racemic pantoprazole the first seven days of treatment in patients with gastroesophageal reflux disease. Revista de Gastroenterología de México (English Edition) 2020;85:48
    https://doi.org/10.1016/j.rgmxen.2019.02.016
  103. Krista L. Niece, Natalie K. Boyd, Kevin S. Akers. In VitroStudy of the Variable Effects of Proton Pump Inhibitors on Voriconazole. Antimicrob. Agents Chemother. 2015;59:5548
    https://doi.org/10.1128/AAC.00884-15
  104. Pietro Enea Lazzerini, Alessandra Cartocci, Yongxia Sarah Qu, Simona Saponara, Simone Furini, Fabio Fusi, Frank Fabris, Alessandra Gamberucci, Nabil El-Sherif, Gabriele Cevenini, Francesco Pettini, Franco Laghi-Pasini, Maurizio Acampa, Iacopo Bertolozzi, Pier Leopoldo Capecchi, Deana Lazaro, Mohamed Boutjdir. Proton Pump Inhibitors Directly Block hERG-Potassium Channel and Independently Increase the Risk of QTc Prolongation in a Large Cohort of US Veterans. Circ: Arrhythmia and Electrophysiology 2021;14
    https://doi.org/10.1161/CIRCEP.121.010042
  105. Artem Minalyan, Lilit Gabrielyan, David Scott, Jonathan Jacobs, Joseph R. Pisegna. The Gastric and Intestinal Microbiome: Role of Proton Pump Inhibitors. Curr Gastroenterol Rep 2017;19
    https://doi.org/10.1007/s11894-017-0577-6
  106. Nihal El Rouby, John J. Lima, Julie A. Johnson. Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine. Expert Opinion on Drug Metabolism & Toxicology 2018;14:447
    https://doi.org/10.1080/17425255.2018.1461835
  107. Xiuyu Sui, Jin Guan, Xiaoyu Li, Lei Gu, Feng Yan, Shuang Shi, Dongxiang Zhang. Preparation of a polydopamine/β‐cyclodextrin coated open tubular capillary electrochromatography column and application for enantioseparation of five proton pump inhibitors. J. Sep. Sci. 2021
    https://doi.org/10.1002/jssc.202100298
  108. Antonio Pirodda, Maria Chiara Raimondi, Arrigo Francesco Giuseppe Cicero, Martina Rosticci, Elisa Rebecca Rinaldi, Lara Bellacosa, Vincenzo Stanghellini, Claudio Borghi. Tinnitus in patients on therapy with proton pump inhibitors (PPI) and in PPI non-users. Hearing, Balance and Communication 2014;12:84
    https://doi.org/10.3109/21695717.2014.902554
  109. Shuqin Zhou, Debra J. Skaar, Pamala A. Jacobson, R. Stephanie Huang. Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit. Front. Pharmacol. 2018;9
    https://doi.org/10.3389/fphar.2018.01436
  110. Khaled A. Shibany, Stefanie L. Pratt, Mohammed Aldurdunji, Sabine Totemeyer, Stuart W. Paine. Prediction of pharmacokinetic clearance and potential Drug-Drug interactions for omeprazole in the horse using in vitro systems. Xenobiotica 2020;50:1220
    https://doi.org/10.1080/00498254.2020.1764131
  111. Yu Kyung Cho, Myung-Gyu Choi, Suck Chei Choi, Kee Myung Lee, Tae Oh Kim, Soo-Heon Park, Jeong Seop Moon, Yun Jeong Lim, Dae Hwan Kang, Gab Jin Cheon, Gwang Ho Baik, Kyoung Oh Kim, Kwang Bum Cho, Jin Seok Jang, Jong-Jae Park, Byoung Kwan Son, Hye-Kyung Jung, Byung-Wook Kim, Sung Kuk Kim, Soo Teik Lee, Jae Myung Cha, Ah Rong Kim, Eun Ji Kim, Hyun Wook Park, Geun Seog Song. Randomised clinical trial: tegoprazan, a novel potassium-competitive acid blocker, or lansoprazole in the treatment of gastric ulcer. Aliment Pharmacol Ther 2020;52:789
    https://doi.org/10.1111/apt.15865
  112. Michael Kukulka, Sai Nudurupati, Maria Claudia Perez. Pharmacokinetics and pharmacodynamics of an orally disintegrating tablet formulation of dexlansoprazole. Therap Adv Gastroenterol 2016;9:759
    https://doi.org/10.1177/1756283X16670073
  113. Roman A. Sukhovershin, John P. Cooke. How May Proton Pump Inhibitors Impair Cardiovascular Health?. Am J Cardiovasc Drugs 2016;16:153
    https://doi.org/10.1007/s40256-016-0160-9
  114. Regis R Vieira, Luís Eduardo S Fontes, Rafael L Pacheco, Marcos AP Fernandes, Paloma P Malta, Rachel Riera. Proton pump inhibitor- and clarithromycin-based triple therapies for Helicobacter pylori eradication. 2020
    https://doi.org/10.1002/14651858.CD013734
  115. Mohammed Albatany, Valeriy G. Ostapchenko, Susan Meakin, Robert Bartha. Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms. J Neurooncol 2019;144:453
    https://doi.org/10.1007/s11060-019-03251-7
  116. Ruben Gomez-Sanchez, Stephen Besley, Zoe Zeliku, Robert J. Young. Method Development and Application of an Accelerated Solution Stability Screen for Drug Discovery. SLAS DISCOVERY: Advancing the Science of Drug Discovery 2020;25:1191
    https://doi.org/10.1177/2472555220931795
  117. Lateef Ahmad, Zafar Iqbal, Yasar Shah, D. G. Watson, Abad Khan, Muhammad Imran Khan, Fazli Khuda, Abbas Khan, Fazli Nasir. Simple and Fast Liquid Chromatography–Mass Spectrometry (LC–MS) Method for the Determination of Omeprazole, 5-hydroxyomeprazole, and Omeprazole Sulphone in Human Plasma. Journal of Liquid Chromatography & Related Technologies 2015;38:692
    https://doi.org/10.1080/10826076.2014.951763
  118. Elise Pape, Delphine Michel, Julien Scala-Bertola, Thomas Schiestel, Alexandre Harlé, Stéphane Bouchet, Audrey Contet, Cécile Pochon, Nicolas Gambier. Effect of esomeprazole on the oral absorption of dasatinib in a patient with Philadelphia-positive acute lymphoblastic leukemia. Br J Clin Pharmacol 2016;81:1195
    https://doi.org/10.1111/bcp.12895
  119. Agnieszka Wiesner, Małgorzata Zwolińska-Wcisło, Paweł Paśko. Effect of Food and Dosing Regimen on Safety and Efficacy of Proton Pump Inhibitors Therapy—A Literature Review. IJERPH 2021;18:3527
    https://doi.org/10.3390/ijerph18073527
  120. Endre Csiki, Hanna Szabó, Lilla Hanák, Zsolt Szakács, Szabolcs Kiss, Nóra Vörhendi, Dániel Pécsi, Eszter Hegyi, Péter Hegyi, Bálint Erőss. Oral Proton Pump Inhibitors May Be as Effective as Intravenous in Peptic Ulcer Bleeding: A Systematic Review and Meta-analysis. Clin Transl Gastroenterol 2021;12:e00341
    https://doi.org/10.14309/ctg.0000000000000341
  121. NohaMahmoud Elkhodary, KhaledAbdalkader Farrag, AmanyMahmoud Elokaby, GamalAbd El-Hay Omran. Efficacy and safety of 7 days versus 10 days triple therapy based on levofloxacin-dexlansoprazole for eradication of Helicobacter pylori: A pilot randomized trial. Indian J Pharmacol 2020;52:356
    https://doi.org/10.4103/ijp.IJP_364_19
  122. Raimunda SN Brilhante, Maria G da Rocha, Jonathas S de Oliveira, Jaime DA España, Vandbergue S Pereira, Débora de SCM Castelo-Branco, Waldemiro de A Pereira-Neto, José JC Sidrim, Rossana de A Cordeiro, Marcos FG Rocha. Proton pump inhibitors versus Cryptococcus species: effects on in vitro susceptibility and melanin production. Future Microbiology 2019;14:489
    https://doi.org/10.2217/fmb-2018-0340
  123. Natalia Estrada-Ortiz, Elena Lopez-Gonzales, Ben Woods, Stefan Stürup, Inge A. M. de Graaf, Geny M. M. Groothuis, Angela Casini. Ex vivo toxicological evaluation of experimental anticancer gold(i) complexes with lansoprazole-type ligands. 2019;8:885
    https://doi.org/10.1039/c9tx00149b
  124. Syed Mohammed Basheeruddin Asdaq, Marah ALbasha, Asmaa Almutairi, Reham Alyabisi, Alaa Almuhaisni, Roaa Faqihi, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani. Use of proton pump inhibitors: An exploration of awareness, attitude and behavior of health care professionals of Riyadh, Saudi Arabia. Saudi Pharmaceutical Journal 2021;29:713
    https://doi.org/10.1016/j.jsps.2021.04.033
  125. Steven C. Mitini-Nkhoma, Narmada Fernando, G. K. D. Ishaka, Shiroma M. Handunnetti, Sisira L. Pathirana, Enrique Ortega. Ion Transport Modulators Differentially Modulate Inflammatory Responses in THP-1-Derived Macrophages. Journal of Immunology Research 2021;2021:1
    https://doi.org/10.1155/2021/8832586
  126. Olha V. Makarenko, Malika M. Karimova, Alona M. Masheiko, Nataliia M. Onul. QUALIMETRIC ANALYSIS OF PROTON PUMP INHIBITORS IN UKRAINE. Wiad Lek 2019;72:1769
    https://doi.org/10.36740/WLek201909212
  127. Ana Ruiz-Garcia, Joanna C. Masters, Laure Mendes da Costa, Robert R. LaBadie, Yali Liang, Grace Ni, Craig A. Ellery, Tanya Boutros, Zelanna Goldberg, Carlo L. Bello. Effect of food or proton pump inhibitor treatment on the bioavailability of dacomitinib in healthy volunteers. The Journal of Clinical Pharmacology 2016;56:223
    https://doi.org/10.1002/jcph.588
  128. Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes, Mauricio Orlando Nava Mesa. Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences. Neural Plasticity 2018;2018:1
    https://doi.org/10.1155/2018/5257285
  129. Jin Liu, Ning Huang, Ning Li, Si-Nian Liu, Min-Hui Li, Hua Li, Xing-Yan Luo, Yan-Tang Wang, Li-Mei Li, Qiang Zou, Yang Liu, Tai Yang. 2-(1H-Benzimidazol-2-yl)-4,5,6,7-tetrahydro-2H-indazol-3-ol, a Benzimidazole Derivative, Inhibits T Cell Proliferation Involving H+/K+-ATPase Inhibition. Molecules 2014;19:17173
    https://doi.org/10.3390/molecules191117173
  130. Neda O. Anastassova, Anelia Ts. Mavrova, Denitsa Y. Yancheva, Magdalena S. Kondeva-Burdina, Virginia I. Tzankova, Simeon S. Stoyanov, Boris L. Shivachev, Rositsa P. Nikolova. Hepatotoxicity and antioxidant activity of some new N,N′-disubstituted benzimidazole-2-thiones, radical scavenging mechanism and structure-activity relationship. Arabian Journal of Chemistry 2018;11:353
    https://doi.org/10.1016/j.arabjc.2016.12.003
  131. Zhimin Chen, Fangliang Gan, Xiali Rao, Xiaoxiao Huang, Huafang Chen. Pharmacokinetics, Bioequivalence, and Safety Studies of Pantoprazole Sodium Enteric‐Coated Tablets in Healthy Subjects. Clinical Pharmacology in Drug Development 2021;10:502
    https://doi.org/10.1002/cpdd.888
  132. Hólmfríður Helgadóttir, Sigrún H. Lund, Sveinbjörn Gizurarson, Helge Waldum, Einar S. Björnsson. Pharmacokinetics of single and repeated oral doses of esomeprazole and gastrin elevation in healthy males and females. Scandinavian Journal of Gastroenterology 2021;56:128
    https://doi.org/10.1080/00365521.2020.1859610
  133. Samaneh Soleymani, Roodabeh Bahramsoltani, Roja Rahimi, Mohammad Abdollahi. Clinical risks of St John’s Wort (Hypericum perforatum) co-administration. Expert Opinion on Drug Metabolism & Toxicology 2017;13:1047
    https://doi.org/10.1080/17425255.2017.1378342
  134. Neetu Soni, Namrata Soni, Rahul Maheshwari, Shreya Thakkar, Dilip Sharma, Rakesh K. Tekade, Nagaraja Sreeharsha, Muktika Tekade. The Future of Pharmaceutical Product Development and Research. 2017.
    https://doi.org/10.1016/B978-0-12-814455-8.00012-8
  135. Andrea Canitano, Elisabetta Iessi, Enrico Pierluigi Spugnini, Cristina Federici, Stefano Fais. Proton pump inhibitors induce a caspase-independent antitumor effect against human multiple myeloma. Cancer Letters 2016;376:278
    https://doi.org/10.1016/j.canlet.2016.04.015
  136. Kyu-Nam Kim, Sung-Won Yang, Hyunil Kim, Seong Shin Kwak, Young-Sang Kim, Doo-Yeoun Cho. Acid Inhibitory Effect of a Combination of Omeprazole and Sodium Bicarbonate (CDFR0209) Compared With Delayed-Release Omeprazole 40 mg Alone in Healthy Adult Male Subjects. Clinical Pharmacology in Drug Development 2018;7:53
    https://doi.org/10.1002/cpdd.331
  137. Yunju Jo, Eunkyoung Park, Sang Bong Ahn, Young Kwan Jo, Byungkwan Son, Seong Hwan Kim, Young Sook Park, Hyo Jeong Kim. A Proton Pump Inhibitor's Effect on Bone Metabolism Mediated by Osteoclast Action in Old Age: A Prospective Randomized Study. Gut Liver 2015;9
    https://doi.org/10.5009/gnl14135
  138. Youssef Rouphael, Giampaolo Raimondi, Luigi Lucini, Petronia Carillo, Marios C. Kyriacou, Giuseppe Colla, Valerio Cirillo, Antonio Pannico, Christophe El-Nakhel, Stefania De Pascale. Physiological and Metabolic Responses Triggered by Omeprazole Improve Tomato Plant Tolerance to NaCl Stress. Front. Plant Sci. 2018;9
    https://doi.org/10.3389/fpls.2018.00249
  139. Maria Marinescu, Ludmila Otilia Cinteză, George Iuliu Marton, Mariana-Carmen Chifiriuc, Marcela Popa, Ioana Stănculescu, Christina-Marie Zălaru, Cristina-Elena Stavarache. Synthesis, density functional theory study and in vitro antimicrobial evaluation of new benzimidazole Mannich bases. BMC Chemistry 2020;14
    https://doi.org/10.1186/s13065-020-00697-z
  140. Adam Chwiesko, Radoslaw Charkiewicz, Jacek Niklinski, Wojciech Luczaj, Elzbieta Skrzydlewska, Robert Milewski, Andrzej Baniukiewicz, Eugeniusz Wroblewski, Mariusz Rosolowski, Andrzej Dabrowski. Effects of different omeprazole dosing on gastric pH in non-variceal upper gastrointestinal bleeding: A randomized prospective study. Journal of Digestive Diseases 2016;17:588
    https://doi.org/10.1111/1751-2980.12393
  141. Mehmet Aslan, Yilmaz Celik, Sevdegul Karadas, Sehmus Olmez, Adem Cifci. Liver hepatotoxicity associated with pantoprazole: a rare case report. Wien Klin Wochenschr 2014;126:390
    https://doi.org/10.1007/s00508-014-0535-3
  142. Ameena Benchamana, Hiroyuki Mori, Ormond A. MacDougald, Sunhapas Soodvilai. Regulation of adipocyte differentiation and metabolism by lansoprazole. Life Sciences 2019;239:116897
    https://doi.org/10.1016/j.lfs.2019.116897
  143. S. Sobrino-Cossío, O. Teramoto-Matsubara, G. Mateos-Pérez, J.M. Abdo-Francis, J. Tawil, C. Olguín-Ramírez, A. Orozco-Gamiz, E.S. Galvis-García. In search of the grail: A race for acid suppression. Revista de Gastroenterología de México (English Edition) 2019;84:344
    https://doi.org/10.1016/j.rgmxen.2019.04.001
  144. Naren Nallapeta, Jessica L. Reynolds, Smita Bakhai. Deprescribing Proton Pump Inhibitors in an Academic, Primary Care Clinic. 2020;54:864
    https://doi.org/10.1097/MCG.0000000000001317
  145. C. Launois, P. Mulette, J. Ancel, S. Dury, J. Hagenburg, F. Lebargy, V. Dormoy, G. Deslee, J.-M. Perotin. Traitement du reflux gastro-œsophagien dans l’asthme. Revue des Maladies Respiratoires 2021
    https://doi.org/10.1016/j.rmr.2021.04.013
  146. Rajnish Kumar, Amit Kumar, Agneta Nordberg, Bengt Långström, Taher Darreh‐Shori. Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme—A plausible missing link for their association with incidence of dementia. Alzheimer's & Dementia 2020;16:1031
    https://doi.org/10.1002/alz.12113
  147. Yuuichi Sakurai, Madoka Shiino, Hiroyuki Okamoto, Akira Nishimura, Koki Nakamura, Setsuo Hasegawa. Pharmacokinetics and Safety of Triple Therapy with Vonoprazan, Amoxicillin, and Clarithromycin or Metronidazole: A Phase 1, Open-Label, Randomized, Crossover Study. Adv Ther 2016;33:1519
    https://doi.org/10.1007/s12325-016-0374-x
  148. Saifur Rahman, Taufiq Rahman. Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway. Sci Rep 2017;7
    https://doi.org/10.1038/s41598-017-13343-x
  149. A. M. Amin, M. M. Omar, S. M. Abd-elhaliem, A. A. Elshanawany. Gastric ulcer localization: Potential use of 125I-omeprazole as radiotracer. Radiochemistry 2015;57:182
    https://doi.org/10.1134/S1066362215020113
  150. I. G. Pakhomova, G. Yu. Knorring, T. N. Kochegura, E. Yu. Pavlova. Differentiated approach to the choice of PPI in a patient with GERD in the practice of an outpatient (with a clinical case). Medicinskij sovet 2021:118
    https://doi.org/10.21518/2079-701X-2020-21-118-125
  151. Miao Yan, Zhu-feng Wu, Dan Tang, Feng Wang, Yi-wen Xiao, Ping Xu, Bi-kui Zhang, Yi-ping Liu, Da-xiong Xiang, Hoan Linh Banh. The impact of proton pump inhibitors on the pharmacokinetics of voriconazole in vitro and in vivo. Biomedicine & Pharmacotherapy 2018;108:60
    https://doi.org/10.1016/j.biopha.2018.08.121
  152. Julian Wolfes, Christian Ellermann, Sophie Burde, Patrick Leitz, Nils Bögeholz, Kevin Willy, Michael Fehr, Lars Eckardt, Gerrit Frommeyer. Concomitant Treatment with Proton Pump Inhibitors and Cephalosporins Does Not Enhance QT-Associated Proarrhythmia in Isolated Rabbit Hearts. Cardiovasc Toxicol 2020;20:531
    https://doi.org/10.1007/s12012-020-09577-3
  153. Prashanth Porayette, David Flockhart, Sandeep K. Gupta. One Size Fits One: Pharmacogenetics in Gastroenterology. Clinical Gastroenterology and Hepatology 2014;12:565
    https://doi.org/10.1016/j.cgh.2014.01.035
  154. Dawei Yu, Qingqing Zhang, Bram De Jaegher, Jibao Liu, Qianwen Sui, Xiang Zheng, Yuansong Wei. Effect of proton pump inhibitor on microbial community, function, and kinetics in anaerobic digestion with ammonia stress. Bioresource Technology 2021;319:124118
    https://doi.org/10.1016/j.biortech.2020.124118
  155. Jong‐Lyul Ghim, May Chien Chin, Jinah Jung, Jiwon Lee, Seokuee Kim, Bongtae Kim, Geun Seog Song, Young‐Kyung Choi, Jae‐Gook Shin. Pharmacokinetics and Pharmacodynamics of Tegoprazan Coadministered With Amoxicillin and Clarithromycin in Healthy Subjects. The Journal of Clinical Pharmacology 2021;61:913
    https://doi.org/10.1002/jcph.1805
  156. TAI YANG, MIN-HUI LI, JIN LIU, NING HUANG, NING LI, SI-NIAN LIU, YANG LIU, TAO ZHANG, QIANG ZOU, HUA LI. Benzimidazole derivative, BMT-1, induces apoptosis in multiple myeloma cells via a mitochondrial-mediated pathway involving H+/K+-ATPase inhibition. 2014;31:2743
    https://doi.org/10.3892/or.2014.3122
  157. Steven C. Mitini-Nkhoma, Narmada Fernando, G. K. D. Ishaka, Shiroma M. Handunnetti, Sisira L. Pathirana, Alexander S. Apt. Ion Transport Modulators as Antimycobacterial Agents. Tuberculosis Research and Treatment 2020;2020:1
    https://doi.org/10.1155/2020/3767915
  158. Nobuhiro Inatomi, Jun Matsukawa, Yuuichi Sakurai, Kazuyoshi Otake. Potassium-competitive acid blockers: Advanced therapeutic option for acid-related diseases. Pharmacology & Therapeutics 2016;168:12
    https://doi.org/10.1016/j.pharmthera.2016.08.001
  159. Man Yu, Carol Lee, Marina Wang, Ian F. Tannock. Influence of the proton pump inhibitor lansoprazole on distribution and activity of doxorubicin in solid tumors. Cancer Sci 2015;106:1438
    https://doi.org/10.1111/cas.12756
  160. Kenji Ikemura, Shunichi Hiramatsu, Masahiro Okuda. Drug Repositioning of Proton Pump Inhibitors for Enhanced Efficacy and Safety of Cancer Chemotherapy. Front. Pharmacol. 2017;8
    https://doi.org/10.3389/fphar.2017.00911
  161. Shu-Kai Zhan, Xiao-Qin Wu, Feng-Ping Zheng, Fabiana Zingone. Clinical Characteristics and Manifestations of Fungal Esophagitis: A Single-Center Experience in South China. Gastroenterology Research and Practice 2021;2021:1
    https://doi.org/10.1155/2021/8869494
  162. Michael Kukulka, Sai Nudurupati, Maria Claudia Perez. Bioavailability, safety, and pharmacodynamics of delayed-release dexlansoprazole administered as two 30 mg orally disintegrating tablets or one 60 mg capsule. Therap Adv Gastroenterol 2016;9:770
    https://doi.org/10.1177/1756283X16666800
  163. Emre Yucel, Mesut Sancar, Aylin Yucel, Betul Okuyan. Adverse drug reactions due to drug–drug interactions with proton pump inhibitors: assessment of systematic reviews with AMSTAR method. Expert Opinion on Drug Safety 2016;15:223
    https://doi.org/10.1517/14740338.2016.1128413
  164. Yusmiati Yusmiati, Dewi Muliaty. The Pharmacogenetics of Cytochrome P450 2C19 Enzymes - Effects on Clopidogrel and Proton Pump Inhibitors. Indones Biomed J 2014;6:33
    https://doi.org/10.18585/inabj.v6i1.41
  165. Martin Michaelis, Malte C. Kleinschmidt, Denisa Bojkova, Holger F. Rabenau, Mark N. Wass, Jindrich Cinatl Jr.. Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2. Front. Microbiol. 2019;10
    https://doi.org/10.3389/fmicb.2019.02790
  166. Lihua Wu, Jian Liu, Yunliang Zheng, You Zhai, Meihua Lin, Guolan Wu, Duo Lv, Jianzhong Shentu. Pharmacokinetic/Pharmacodynamic Evaluation of Dexlansoprazole Infusion Injection Compared with Lansoprazole in Healthy Chinese Adults. Clin Drug Investig 2019;39:953
    https://doi.org/10.1007/s40261-019-00824-2
  167. Chih-Ming Liang, Ming-Te Kuo, Pin-I Hsu, Chao-Hung Kuo, Wei-Chen Tai, Shih-Cheng Yang, Keng-Liang Wu, Hsing-Ming Wang, Chih-Chien Yao, Cheng-En Tsai, Yao-Kuang Wang, Jiunn-Wei Wang, Chih-Fang Huang, Deng-Chyang Wu. First-week clinical responses to dexlansoprazole 60 mg and esomeprazole 40 mg for the treatment of grades A and B gastroesophageal reflux disease. WJG 2017;23:8395
    https://doi.org/10.3748/wjg.v23.i47.8395
  168. Benjamin Ka Seng Thong, Soelaiman Ima-Nirwana, Kok-Yong Chin. Proton Pump Inhibitors and Fracture Risk: A Review of Current Evidence and Mechanisms Involved. IJERPH 2019;16:1571
    https://doi.org/10.3390/ijerph16091571
  169. S. Sobrino-Cossío, O. Teramoto-Matsubara, G. Mateos-Pérez, J.M. Abdo-Francis, J. Tawil, C. Olguín-Ramírez, A. Orozco-Gamiz, E.S. Galvis-García. La búsqueda del Grial: una carrera por la supresión ácida. Revista de Gastroenterología de México 2019;84:344
    https://doi.org/10.1016/j.rgmx.2019.04.002
  170. Jonathan Leis, Chi-Hao Luan, James E. Audia, Sara F. Dunne, Carissa M. Heath, Jae U. Jung. Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells. J Virol 2021;95
    https://doi.org/10.1128/JVI.00190-21