Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Cited by CrossRef (156)

  1. Andrea Shin, Geoffrey A. Preidis, Robert Shulman, Purna C. Kashyap. The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders. Clinical Gastroenterology and Hepatology 2019;17:256
    https://doi.org/10.1016/j.cgh.2018.08.054
  2. Evelyn Xiu Ling Loo, De Yun Wang, Kewin Tien Ho Siah. Association between Irritable Bowel Syndrome and Allergic Diseases: To Make a Case for Aeroallergen. Int Arch Allergy Immunol 2020;181:31
    https://doi.org/10.1159/000503629
  3. Dale Wilson, Malkanthi Evans, Eric Weaver, Audrey L. Shaw, Gerald L. Klein. Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects with Diarrhea-Predominant Irritable Bowel Syndrome. Clin Med Insights Gastroenterol 2013;6:CGast.S13200
    https://doi.org/10.4137/CGast.S13200
  4. Dervla O’Malley, Maria M. Buckley, Declan P. McKernan, Eamonn M.M. Quigley, John F. Cryan, Timothy G. Dinan. Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons. Brain, Behavior, and Immunity 2015;44:57
    https://doi.org/10.1016/j.bbi.2014.08.005
  5. De-Rong Liu, Xiao-Juan Xu, Shu-Kun Yao. Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome. WJG 2018;24:46
    https://doi.org/10.3748/wjg.v24.i1.46
  6. J. B. J. Kamphuis, Laurent Reber, H. Eutamène, V. Theodorou. Increased fermentable carbohydrate intake alters colonic mucus barrier function through glycation processes and increased mast cell counts. The FASEB Journal 2022;36
    https://doi.org/10.1096/fj.202100494RRR
  7. Keishi Komori, Eikichi Ihara, Hirotada Akiho. Irritable Bowel Syndrome. 2022.
    https://doi.org/10.1007/978-981-97-8410-3_6
  8. Tamar Ringel-Kulka, Chang Hwan Choi, Daniel Temas, Ari Kim, Daniele M Maier, Karen Scott, Joseph A Galanko, Yehuda Ringel. Altered Colonic Bacterial Fermentation as a Potential Pathophysiological Factor in Irritable Bowel Syndrome. 2015;110:1339
    https://doi.org/10.1038/ajg.2015.220
  9. Swapnajeet Sahoo, Susanta Kumar Padhy. Cross‐cultural and psychological issues in irritable bowel syndrome. J of Gastro and Hepatol 2017;32:1679
    https://doi.org/10.1111/jgh.13773
  10. О. N. Мinushkin. Irritable bowel syndrome: shifts in point of view. Medicinskij sovet 2023:168
    https://doi.org/10.21518/ms2022-054
  11. Mio Kodani, Hirokazu Fukui, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Hiroto Miwa. Association between gastrointestinal motility and macrophage/mast cell distribution in mice during the healing stage after DSS‑induced colitis. Mol Med Report 2018
    https://doi.org/10.3892/mmr.2018.8926
  12. B. Jonefjäll, H. Strid, L. Öhman, J. Svedlund, A. Bergstedt, M. Simren. Characterization of IBS‐like symptoms in patients with ulcerative colitis in clinical remission. Neurogastroenterology Motil 2013;25:756
    https://doi.org/10.1111/nmo.12163
  13. Kyeong Ok Kim. Functional Gastrointestinal Disorders in Patients with Inflammatory Bowel Disease. Korean J Gastroenterol 2022;79:4
    https://doi.org/10.4166/kjg.2022.001
  14. B Sivaprakash. Physiology and Neurobiology of Stress and the Implications for Physical Health . 2014;3:25
    https://doi.org/10.5005/jp-journals-10085-3105
  15. Adrian Szczepaniak, Marta Zielińska. A Comprehensive Overview of Irritable Bowel Syndrome. 2014.
    https://doi.org/10.1016/B978-0-12-821324-7.00004-6
  16. Giovanni Barbara, Cesare Cremon, Vito Annese, Guido Basilisco, Franco Bazzoli, Massimo Bellini, Antonio Benedetti, Luigi Benini, Fabrizio Bossa, Paola Buldrini, Michele Cicala, Rosario Cuomo, Bastianello Germanà, Paola Molteni, Matteo Neri, Marcello Rodi, Alfredo Saggioro, Maria Lia Scribano, Maurizio Vecchi, Giorgio Zoli, Roberto Corinaldesi, Vincenzo Stanghellini. Randomised controlled trial of mesalazine in IBS. Gut 2016;65:82
    https://doi.org/10.1136/gutjnl-2014-308188
  17. Gian Paolo Caviglia, Alessandra Tucci, Rinaldo Pellicano, Sharmila Fagoonee, Chiara Rosso, Maria Lorena Abate, Antonella Olivero, Angelo Armandi, Ester Vanni, Giorgio Maria Saracco, Elisabetta Bugianesi, Marco Astegiano, Davide Giuseppe Ribaldone. Clinical Response and Changes of Cytokines and Zonulin Levels in Patients with Diarrhoea-Predominant Irritable Bowel Syndrome Treated with Bifidobacterium Longum ES1 for 8 or 12 Weeks: A Preliminary Report. JCM 2020;9:2353
    https://doi.org/10.3390/jcm9082353
  18. Senbao Xu, Qiuyan Luo, Jian He, Xiling Chen, Simin Li, Yang Bai. Causal associations of 25-hydroxyvitamin D with functional gastrointestinal disorders: a two-sample Mendelian randomization study. Genes Nutr 2023;18
    https://doi.org/10.1186/s12263-023-00734-1
  19. J. Boyer, M.‐C. Saint‐Paul, B. Dadone, S. Patouraux, M.‐H. Vivinus, D. Ouvrier, J.‐F. Michiels, T. Piche, M. K. Tulic. Inflammatory cell distribution in colon mucosa as a new tool for diagnosis of irritable bowel syndrome: A promising pilot study. Neurogastroenterology Motil 2018;30
    https://doi.org/10.1111/nmo.13223
  20. Lifang Fan, Mary Wong, Xuemo (Sean) Fan, Yuntian Hong, Kongliang Sun, Congqing Jiang, Xiaoyu Xie, Hanlin L. Wang. Quantitative Analysis of Intramucosal Mast Cells in Irritable Bowel Syndrome. 2021;55:244
    https://doi.org/10.1097/MCG.0000000000001394
  21. Muhammad Sohail Arshad, Sameen Fatima, Kazem Nazari, Radeyah Ali, Muhammad Farhan, Syed Aun Muhammad, Nasir Abbas, Amjad Hussain, Israfil Kucuk, Ming-Wei Chang, Prina Mehta, Zeeshan Ahmad. Engineering and characterisation of BCG-loaded polymeric microneedles. Journal of Drug Targeting 2020;28:525
    https://doi.org/10.1080/1061186X.2019.1693577
  22. Li Cheng, Qing Qing Luo, Sheng Liang Chen. The role of intestinal mast cell infiltration in irritable bowel syndrome. J of Digest Diseases 2021;22:143
    https://doi.org/10.1111/1751-2980.12971
  23. Sarah L. Eady, Alison J. Wallace, Duncan I. Hedderley, Kerry L. Bentley-Hewitt, Christine A. Butts. The Effects on Immune Function and Digestive Health of Consuming the Skin and Flesh of Zespri® SunGold Kiwifruit (Actinidia Chinensis var. Chinensis ‘Zesy002’) in Healthy and IBS-Constipated Individuals. Nutrients 2020;12:1453
    https://doi.org/10.3390/nu12051453
  24. Fiorella Giancola, Umberto Volta, Roberta Repossi, Rocco Latorre, Dorien Beeckmans, Florencia Carbone, Karen Van den Houte, Francesca Bianco, Elena Bonora, Alessandra Gori, Anna Costanzini, Elisa Boschetti, Giacomo Caio, Tim Vanuytsel, Vincenzo Stanghellini, Jan Tack, Roberto De Giorgio. Mast cell‐nerve interactions correlate with bloating and abdominal pain severity in patients with non‐celiac gluten / wheat sensitivity. Neurogastroenterology Motil 2020;32
    https://doi.org/10.1111/nmo.13814
  25. Julia König, María Fernanda Roca Rubio, Richard A. Forsgård, Julia Rode, Jakob Axelsson, Gianfranco Grompone, Robert J. Brummer, Imad Al Kassaa. The effects of a 6-week intervention with Limosilactobacillus reuteri ATCC PTA 6475 alone and in combination with L. reuteri DSM 17938 on gut barrier function, immune markers, and symptoms in patients with IBS-D—An exploratory RCT. PLoS ONE 2024;19:e0312464
    https://doi.org/10.1371/journal.pone.0312464
  26. Amy E. Foxx-Orenstein. New and emerging therapies for the treatment of irritable bowel syndrome: an update for gastroenterologists. Therap Adv Gastroenterol 2016;9:354
    https://doi.org/10.1177/1756283X16633050
  27. Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara. Management of Irritable Bowel Syndrome With Diarrhea. 2024
    https://doi.org/10.1097/MCG.0000000000001964
  28. Jean Carlos Fernando Besson, Isadora Carolina Rissi Colombo , Enrique Ayres de Oliveira. SÍNDROME DO INTESTINO IRRITÁVEL NO CONTEXTO DE ESTRESSE CRÔNICO VIVENCIADO PELOS ESTUDANTES DE MEDICINA. Rev. Contemp. 2025;5:e7748
    https://doi.org/10.56083/RCV5N3-078
  29. S. Mahurkar, C. Polytarchou, D. Iliopoulos, C. Pothoulakis, E. A. Mayer, L. Chang. Genome‐wide DNA methylation profiling of peripheral blood mononuclear cells in irritable bowel syndrome. Neurogastroenterology Motil 2016;28:410
    https://doi.org/10.1111/nmo.12741
  30. Yu. P. Uspenskiy, O. S. Mirzoev, Yu. A. Fominykh, A. A. Gnutov, S. V. Polyushkin. Efficacy of Kolofort in Combined Functional Gastroenterological Pathology: an Open Study. Rossijskij žurnal gastroènterologii, gepatologii, koloproktologii 2020;30:30
    https://doi.org/10.22416/1382-4376-2020-30-5-30-41
  31. Umberto Volta, Maria Ines Pinto-Sanchez, Elisa Boschetti, Giacomo Caio, Roberto De Giorgio, Elena F Verdu. Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten?. J Neurogastroenterol Motil 2016;22:547
    https://doi.org/10.5056/jnm16069
  32. Roberto De Giorgio, Umberto Volta, Peter R Gibson. Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction?. Gut 2016;65:169
    https://doi.org/10.1136/gutjnl-2015-309757
  33. Amir Abbasnezhad, Razieh Choghakhori. Dietary Interventions in Gastrointestinal Diseases. 2016.
    https://doi.org/10.1016/B978-0-12-814468-8.00007-7
  34. Stephen J. Vanner, Beverley Greenwood-Van Meerveld, Gary M. Mawe, Terez Shea-Donohue, Elena F. Verdu, Jackie Wood, David Grundy. Fundamentals of Neurogastroenterology: Basic Science. Gastroenterology 2016;150:1280
    https://doi.org/10.1053/j.gastro.2016.02.018
  35. Paul Enck, Qasim Aziz, Giovanni Barbara, Adam D. Farmer, Shin Fukudo, Emeran A. Mayer, Beate Niesler, Eamonn M. M. Quigley, Mirjana Rajilić-Stojanović, Michael Schemann, Juliane Schwille-Kiuntke, Magnus Simren, Stephan Zipfel, Robin C. Spiller. Irritable bowel syndrome. Nat Rev Dis Primers 2016;2
    https://doi.org/10.1038/nrdp.2016.14
  36. Chao Du, Lijun Peng, Guanjun Kou, Peng Wang, Lin Lu, Yanqing Li. Assessment of Serum sTREM-1 as a Marker of Subclinical Inflammation in Diarrhea-Predominant Patients with Irritable Bowel Syndrome. Dig Dis Sci 2018;63:1182
    https://doi.org/10.1007/s10620-018-5002-y
  37. O.A. Gizinger. The state of the intestinal microbiota and antimicrobial protection: obtaining and analyzing information. 2020:21
    https://doi.org/10.33920/MED-12-2012-03
  38. Russell Dolan, William D. Chey, Shanti Eswaran. The role of diet in the management of irritable bowel syndrome: a focus on FODMAPs. Expert Review of Gastroenterology & Hepatology 2018;12:607
    https://doi.org/10.1080/17474124.2018.1476138
  39. Gülen Arslan Lied. Indication of Immune Activation in Patients with Perceived Food Hypersensitivity. Dig Dis Sci 2014;59:259
    https://doi.org/10.1007/s10620-013-2926-0
  40. Sean M.P. Bennet, Lena Ohman, Magnus Simren. Gut Microbiota as Potential Orchestrators of Irritable Bowel Syndrome. Gut Liver 2015;9
    https://doi.org/10.5009/gnl14344
  41. Anna Chiara Piscaglia, Lucrezia Laterza, Valentina Cesario, Viviana Gerardi, Rosario Landi, Loris Riccardo Lopetuso, Giovanni Calò, Giovanna Fabbretti, Massimo Brisigotti, Maria Loredana Stefanelli, Antonio Gasbarrini. Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?. WJG 2016;22:10198
    https://doi.org/10.3748/wjg.v22.i46.10198
  42. Giorgio Gargari, Valentina Taverniti, Claudio Gardana, Cesare Cremon, Filippo Canducci, Isabella Pagano, Maria Raffaella Barbaro, Lara Bellacosa, Anna Maria Castellazzi, Chiara Valsecchi, Sara Carlotta Tagliacarne, Massimo Bellini, Lorenzo Bertani, Dario Gambaccini, Santino Marchi, Michele Cicala, Bastianello Germanà, Elisabetta Dal Pont, Maurizio Vecchi, Cristina Ogliari, Walter Fiore, Vincenzo Stanghellini, Giovanni Barbara, Simone Guglielmetti. Fecal Clostridiales distribution and short‐chain fatty acids reflect bowel habits in irritable bowel syndrome. Environmental Microbiology 2018;20:3201
    https://doi.org/10.1111/1462-2920.14271
  43. M. Jovani, G. Fiorino, S. Danese. Commentary: associations between immune activation, intestinal permeability and irritable bowel syndrome. Aliment Pharmacol Ther 2013;37:277
    https://doi.org/10.1111/apt.12136
  44. Michele Pier Luca Guarino, Michele Cicala, Lorenza Putignani, Carola Severi. Gastrointestinal neuromuscular apparatus: An underestimated target of gut microbiota. WJG 2016;22:9871
    https://doi.org/10.3748/wjg.v22.i45.9871
  45. Mohamed Abuelazm, Shoaib Muhammad, Mohamed Gamal, Fatma Labieb, Mostafa Atef Amin, Basel Abdelazeem, James Robert Brašić. The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 2022;14:2618
    https://doi.org/10.3390/nu14132618
  46. Sander J M van Wanrooij, Mira M Wouters, Lukas Van Oudenhove, Winde Vanbrabant, Stéphanie Mondelaers, Patrick Kollmann, Florian Kreutz, Michael Schemann, Guy E Boeckxstaens. Sensitivity Testing in Irritable Bowel Syndrome With Rectal Capsaicin Stimulations: Role of TRPV1 Upregulation and Sensitization in Visceral Hypersensitivity?. 2014;109:99
    https://doi.org/10.1038/ajg.2013.371
  47. Ju Yup Lee, Nayoung Kim, Ji Hyun Park, Ryoung Hee Nam, Sun Min Lee, Chin-Hee Song, Geun Kim, Hee Young Na, Yoon Jin Choi, Jin Joo Kim, Dong Ho Lee. Expression of Neurotrophic Factors, Tight Junction Proteins, and Cytokines According to the Irritable Bowel Syndrome Subtype and Sex. J Neurogastroenterol Motil 2020;26:106
    https://doi.org/10.5056/jnm19099
  48. Eluisa Perna, Javier Aguilera-Lizarraga, Morgane V Florens, Piyush Jain, Stavroula A Theofanous, Nikita Hanning, Joris G De Man, Maya Berg, Benedicte De Winter, Yeranddy A Alpizar, Karel Talavera, Pieter Vanden Berghe, Mira Wouters, Guy Boeckxstaens. Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS. Gut 2021;70:1275
    https://doi.org/10.1136/gutjnl-2020-321530
  49. Rajan Singh, Hannah Zogg, Seungil Ro. Role of microRNAs in Disorders of Gut–Brain Interactions: Clinical Insights and Therapeutic Alternatives. JPM 2021;11:1021
    https://doi.org/10.3390/jpm11101021
  50. Gerard E. Mullin, Sue J. Shepherd, Bani Chander Roland, Carol Ireton‐Jones, Laura E. Matarese. Irritable Bowel Syndrome. J Parenter Enteral Nutr 2014;38:781
    https://doi.org/10.1177/0148607114545329
  51. A. Riba, M. Olier, S. Lacroix-Lamandé, C. Lencina, V. Bacquié, C. Harkat, N. Van Langendonck, M. Gillet, C. Cartier, M. Baron, C. Sommer, V. Mallet, M. Zill, H. Robert, F. Laurent, S. Ellero-Simatos, V. Théodorou, S. Ménard. Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections. Brain, Behavior, and Immunity 2018;73:403
    https://doi.org/10.1016/j.bbi.2018.05.024
  52. Seok-Hoon Lee, Nam-Seok Joo, Kwang-Min Kim, Kyu-Nam Kim. The Therapeutic Effect of a Multistrain Probiotic on Diarrhea-Predominant Irritable Bowel Syndrome: A Pilot Study. Gastroenterology Research and Practice 2018;2018:1
    https://doi.org/10.1155/2018/8791916
  53. Edoardo Savarino, Fabiana Zingone, Brigida Barberio, Giovanni Marasco, Filiz Akyuz, Hale Akpinar, Oana Barboi, Giorgia Bodini, Serhat Bor, Giuseppe Chiarioni, Gheorghe Cristian, Maura Corsetti, Antonio Di Sabatino, Anca Mirela Dimitriu, Vasile Drug, Dan L. Dumitrascu, Alexander C. Ford, Goran Hauser, Radislav Nakov, Nisha Patel, Daniel Pohl, Cătălin Sfarti, Jordi Serra, Magnus Simrén, Alina Suciu, Jan Tack, Murat Toruner, Julian Walters, Cesare Cremon, Giovanni Barbara. Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility. UEG Journal 2022;10:556
    https://doi.org/10.1002/ueg2.12259
  54. Marianne H. Fraher, Paul W. O'Toole, Eamonn M. M. Quigley. Techniques used to characterize the gut microbiota: a guide for the clinician. Nat Rev Gastroenterol Hepatol 2012;9:312
    https://doi.org/10.1038/nrgastro.2012.44
  55. Michael Herzlinger, Carolina Cerezo. Functional Abdominal Pain and Related Syndromes. Child and Adolescent Psychiatric Clinics of North America 2018;27:15
    https://doi.org/10.1016/j.chc.2017.08.006
  56. Jasper B.J. Kamphuis, Bruno Guiard, Mathilde Leveque, Maiwenn Olier, Isabelle Jouanin, Sophie Yvon, Valerie Tondereau, Pauline Rivière, Françoise Guéraud, Sylvie Chevolleau, Maria-Helena Noguer-Meireles, Jean- François Martin, Laurent Debrauwer, Helene Eutamène, Vassilia Theodorou. Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Glycation Processes, Increasing Mast Cell Density in Colonic Mucosa. Gastroenterology 2020;158:652
    https://doi.org/10.1053/j.gastro.2019.10.037
  57. Elaine Meade, Mary Garvey. The Role of Neuro-Immune Interaction in Chronic Pain Conditions; Functional Somatic Syndrome, Neurogenic Inflammation, and Peripheral Neuropathy. IJMS 2022;23:8574
    https://doi.org/10.3390/ijms23158574
  58. M. García Carrasco, C. Mendoza Pinto, A. López Colombo, S. Méndez Martínez, R. Andari Sawaya, M. Muñoz Guarneros, L. Vázquez De Lara, M. Lescas Hernández, A. Montiel Jarquín, G. Ramos Álvarez, M. Schmulson. Irritable bowel syndrome‐type symptoms in female patients with mild systemic lupus erythematosus: frequency, related factors and quality of life. Neurogastroenterology Motil 2013;25:958
    https://doi.org/10.1111/nmo.12230
  59. Theoharis C Theoharides, Shahrzad Asadi, Jihong Chen, Jan D Huizinga. Editorial: Irritable Bowel Syndrome and the Elusive Mast Cells. 2012;107:727
    https://doi.org/10.1038/ajg.2012.61
  60. Kang Nyeong Lee, Oh Young Lee. The Role of Mast Cells in Irritable Bowel Syndrome. Gastroenterology Research and Practice 2016;2016:1
    https://doi.org/10.1155/2016/2031480
  61. Róisín Ní Dhonnabháín, Qiao Xiao, Dervla O’Malley. Aberrant Gut-To-Brain Signaling in Irritable Bowel Syndrome - The Role of Bile Acids. Front. Endocrinol. 2021;12
    https://doi.org/10.3389/fendo.2021.745190
  62. Chi Fung Willis Chow, Sijia Che, Hong-Yan Qin, Hiu Yee Kwan, Zhao-Xiang Bian, Hoi Leong Xavier Wong. From psychology to physicality: how nerve growth factor transduces early life stress into gastrointestinal motility disorders later in life. Cell Cycle 2019;18:1824
    https://doi.org/10.1080/15384101.2019.1637203
  63. Yasunari Kageyama, Yutaka Shimokawa, Kimihiko Kawauchi, Masafumi Morimoto, Koichi Aida, Tetsu Akiyama, Tsutomu Nakamura. Higher Prevalence of Nickel and Palladium Hypersensitivity in Patients with Ulcerative Colitis. Int Arch Allergy Immunol 2020;181:456
    https://doi.org/10.1159/000506633
  64. Rajan Singh, Hannah Zogg, Uday C Ghoshal, Seungil Ro. Current Treatment Options and Therapeutic Insights for Gastrointestinal Dysmotility and Functional Gastrointestinal Disorders. Front. Pharmacol. 2022;13
    https://doi.org/10.3389/fphar.2022.808195
  65. Caterina Carco, Wayne Young, Richard B. Gearry, Nicholas J. Talley, Warren C. McNabb, Nicole C. Roy. Increasing Evidence That Irritable Bowel Syndrome and Functional Gastrointestinal Disorders Have a Microbial Pathogenesis. Front. Cell. Infect. Microbiol. 2020;10
    https://doi.org/10.3389/fcimb.2020.00468
  66. Sang-Hoon Lee, Doo-Yeoun Cho, Seok-Hoon Lee, Kyung-Sun Han, Sung-Won Yang, Jin-Ho Kim, Su-Hyun Lee, Soo-Min Kim, Kyu-Nam Kim. A Randomized Clinical Trial of Synbiotics in Irritable Bowel Syndrome: Dose-Dependent Effects on Gastrointestinal Symptoms and Fatigue. Korean J Fam Med 2019;40:2
    https://doi.org/10.4082/kjfm.17.0064
  67. S. E. Kim, L. Chang. Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms?. Neurogastroenterology Motil 2012;24:895
    https://doi.org/10.1111/j.1365-2982.2012.01993.x
  68. Keith McIntosh, David E Reed, Theresa Schneider, Frances Dang, Ammar H Keshteli, Giada De Palma, Karen Madsen, Premysl Bercik, Stephen Vanner. FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial. Gut 2017;66:1241
    https://doi.org/10.1136/gutjnl-2015-311339
  69. Md. Sharif Shajib, Adriana Baranov, Waliul I. Khan. Diverse Effects of Gut-Derived Serotonin in Intestinal Inflammation. ACS Chem. Neurosci. 2017;8:920
    https://doi.org/10.1021/acschemneuro.6b00414
  70. Fuqiang Yuan, Huijuan Ni, Carl V. Asche, Minchul Kim, Saqib Walayat, Jinma Ren. Efficacy ofBifidobacterium infantis 35624in patients with irritable bowel syndrome: a meta-analysis. Current Medical Research and Opinion 2017;33:1191
    https://doi.org/10.1080/03007995.2017.1292230
  71. Giovanni Dothel, Maria Raffaella Barbaro, Hélène Boudin, Valentina Vasina, Cesare Cremon, Luciana Gargano, Lara Bellacosa, Roberto De Giorgio, Catherine Le Berre-Scoul, Philippe Aubert, Michel Neunlist, Fabrizio De Ponti, Vincenzo Stanghellini, Giovanni Barbara. Nerve Fiber Outgrowth Is Increased in the Intestinal Mucosa of Patients With Irritable Bowel Syndrome. Gastroenterology 2015;148:1002
    https://doi.org/10.1053/j.gastro.2015.01.042
  72. Valentina Leccioli, Mara Oliveri, Marcello Romeo, Massimiliano Berretta, Paola Rossi. A New Proposal for the Pathogenic Mechanism of Non-Coeliac/Non-Allergic Gluten/Wheat Sensitivity: Piecing Together the Puzzle of Recent Scientific Evidence. Nutrients 2017;9:1203
    https://doi.org/10.3390/nu9111203
  73. Qin Qian, Ping Li, Tiancheng Wang, Ji Zhang, Shanfa Yu, Tian Chen, Lei Yan, Yanshuang Song, Xiaohua Liu, Yongen Gu, Yun Wang, Guang Jia. Alteration of Th1/Th2/Th17 cytokine profile and humoral immune responses associated with chromate exposure. Occup Environ Med 2013;70:697
    https://doi.org/10.1136/oemed-2013-101421
  74. Giovanni Barbara, Lisa Zecchi, Raffaella Barbaro, Cesare Cremon, Lara Bellacosa, Marco Marcellini, Roberto De Giorgio, Roberto Corinaldesi, Vincenzo Stanghellini. Mucosal Permeability and Immune Activation as Potential Therapeutic Targets of Probiotics in Irritable Bowel Syndrome. 2012;46:S52
    https://doi.org/10.1097/MCG.0b013e318264e918
  75. Alba Rodríguez-Nogales, Francesca Algieri, Teresa Vezza, José Garrido-Mesa, José Alberto Molina-Tijeras, María Elena Rodríguez-Cabezas, María Pilar Utrilla, Ivo Pischel, Julio Gálvez. Calcium Pyruvate Exerts Beneficial Effects in an Experimental Model of Irritable Bowel Disease Induced by DCA in Rats. Nutrients 2019;11:140
    https://doi.org/10.3390/nu11010140
  76. Ellen Johanne Vara, Cecilie Svanes, Trude D. Skorge, Aud Berstad, Erik Florvaag, Debbie Jarvis, Ernst Omenaas, Marie Waatevik, Ane Johannessen, Gülen Arslan Lied. Functional Gastrointestinal Symptoms Are Associated with Higher Serum Total IgE Levels, but Less Atopic Sensitization. Dig Dis Sci 2016;61:189
    https://doi.org/10.1007/s10620-015-3835-1
  77. Giovanni Di Nardo, Cesare Cremon, Annamaria Staiano, Vincenzo Stanghellini, Osvaldo Borrelli, Caterina Strisciuglio, Claudio Romano, Saverio Mallardo, Elena Scarpato, Giovanni Marasco, Silvia Salvatore, Letizia Zenzeri, Enrico Felici, Licia Pensabene, Simona Sestito, Ruggiero Francavilla, Paolo Quitadamo, Mariella Baldassarre, Valentina Giorgio, Renato Tambucci, Chiara Ziparo, Pasquale Parisi, Maria Raffaella Barbaro, Giovanni Barbara. Role of inflammation in pediatric irritable bowel syndrome. Neurogastroenterology Motil 2023;35
    https://doi.org/10.1111/nmo.14365
  78. Julia König, Robert-Jan Brummer. Pharma-Nutrition. 2023.
    https://doi.org/10.1007/978-3-319-06151-1_4
  79. Carmela Conte, Marzia Sichetti, Giovanna Traina. Gut–Brain Axis: Focus on Neurodegeneration and Mast Cells. Applied Sciences 2020;10:1828
    https://doi.org/10.3390/app10051828
  80. Sambhawa Priya, Michael B. Burns, Tonya Ward, Ruben A. T. Mars, Beth Adamowicz, Eric F. Lock, Purna C. Kashyap, Dan Knights, Ran Blekhman. Identification of shared and disease-specific host gene–microbiome associations across human diseases using multi-omic integration. Nat Microbiol 2022;7:780
    https://doi.org/10.1038/s41564-022-01121-z
  81. Ratnakar Shukla, Ujjala Ghoshal, Tapan N. Dhole, Uday C. Ghoshal. Fecal Microbiota in Patients with Irritable Bowel Syndrome Compared with Healthy Controls Using Real-Time Polymerase Chain Reaction: An Evidence of Dysbiosis. Dig Dis Sci 2015;60:2953
    https://doi.org/10.1007/s10620-015-3607-y
  82. Giovanni Barbara, Christine Feinle-Bisset, Uday C. Ghoshal, Javier Santos, Stepen J. Vanner, Nathalie Vergnolle, Erwin G. Zoetendal, Eamonn M. Quigley. The Intestinal Microenvironment and Functional Gastrointestinal Disorders. Gastroenterology 2016;150:1305
    https://doi.org/10.1053/j.gastro.2016.02.028
  83. O. N. Minushkin. Pharmacological approaches to the treatment of combined functional pathology (biliary and intestinal tract). Med. sov. 2018:78
    https://doi.org/10.21518/2079-701X-2018-14-78-82
  84. Mark L. Dreher. Dietary Patterns and Whole Plant Foods in Aging and Disease. 2018.
    https://doi.org/10.1007/978-3-319-59180-3_6
  85. Mohammad Bashashati, Max J. Schmulson. From gene polymorphisms to serum cytokine levels in irritable bowel syndrome. Clinics and Research in Hepatology and Gastroenterology 2016;40:525
    https://doi.org/10.1016/j.clinre.2016.01.002
  86. HiamF Elsaied, KhaledS Sherra, El-HassaninM Mahmoud, MohamadA Ebrahim. A study of sociodemographic factors and anxiety: depressive disorders among irritable bowel syndrome patients. Egypt J Psychiatr 2017;38:97
    https://doi.org/10.4103/1110-1105.209680
  87. Silvia Perez-Pujol, Omer Aras, Gines Escolar. Factor V Leiden and Inflammation. Thrombosis 2012;2012:1
    https://doi.org/10.1155/2012/594986
  88. Roy Dekel, Douglas A Drossman, Ami D Sperber. The use of psychotropic drugs in irritable bowel syndrome. Expert Opinion on Investigational Drugs 2013;22:329
    https://doi.org/10.1517/13543784.2013.761205
  89. Karolina Skonieczna-Żydecka, Igor Loniewski, Anastasios Koulaouzidis, Wojciech Marlicz. Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications. 2013.
    https://doi.org/10.1016/B978-0-12-815249-2.00026-9
  90. Mengfei Peng, Nana Frekua Kennedy, Andy Truong, Blair Arriola, Ahlam Akmel. Gut Microbiome and Its Impact on Health and Diseases. 2013.
    https://doi.org/10.1007/978-3-030-47384-6_4
  91. A. Abbasnezhad, R. Amani, E. Hajiani, P. Alavinejad, B. Cheraghian, A. Ghadiri. Effect of vitamin D on gastrointestinal symptoms and health‐related quality of life in irritable bowel syndrome patients: a randomized double‐blind clinical trial. Neurogastroenterology Motil 2016;28:1533
    https://doi.org/10.1111/nmo.12851
  92. Ju Yup Lee, Nayoung Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee. A Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of DA-9701 (Motilitone) in Patients With Constipation-type Irritable Bowel Syndrome and Functional Dyspepsia Overlap: A Pilot Study. J Neurogastroenterol Motil 2022;28:265
    https://doi.org/10.5056/jnm20236
  93. Emily A. Beckmann, Claire M. Aarnio-Peterson, Kristen E. Jastrowski Mano. Advancing the Assessment and Treatment of Comorbid Pediatric Chronic Functional Abdominal Pain (CFAP) and Restrictive Eating Disorders. Children 2023;10:1539
    https://doi.org/10.3390/children10091539
  94. Mattia Cappelletti, Emiliana Tognon, Linda Vona, Katia Basello, Andrea Costanzi, Michela Carola Speciani, Attilio Francesco Speciani. Food-specific serum IgG and symptom reduction with a personalized, unrestricted-calorie diet of six weeks in Irritable Bowel Syndrome (IBS). Nutr Metab (Lond) 2020;17
    https://doi.org/10.1186/s12986-020-00528-x
  95. Laurence Guzylack-Piriou, Sandrine Ménard. Early Life Exposure to Food Contaminants and Social Stress as Risk Factor for Metabolic Disorders Occurrence?—An Overview. Biomolecules 2021;11:687
    https://doi.org/10.3390/biom11050687
  96. T. Louwies, B. Greenwood-Van Meerveld. Comprehensive Pharmacology. 2021.
    https://doi.org/10.1016/B978-0-12-820472-6.00037-2
  97. Sang-Yeoup Lee, Hye-Rim Hwang, Yu-Hyeon Yi, Jin-Mi Kim, Yun-Jin Kim, Jeong-Gyu Lee, Young-Hye Cho, Young-Jin Tak, Seung Hun Lee, Eun Ju Park, Youngin Lee. Association between Irritable Bowel Syndrome and Risk of Osteoporosis in Korean Premenopausal Women. Med Princ Pract 2021;30:527
    https://doi.org/10.1159/000517909
  98. Hirokazu Fukui, Xin Xu, Hiroto Miwa. Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders. J Neurogastroenterol Motil 2018;24:367
    https://doi.org/10.5056/jnm18071
  99. Giovanna Traina. Mast Cells in Gut and Brain and Their Potential Role as an Emerging Therapeutic Target for Neural Diseases. Front. Cell. Neurosci. 2019;13
    https://doi.org/10.3389/fncel.2019.00345
  100. Antonio Jesús Ruiz-Malagón, María José Rodríguez-Sanchez, María Jesús Rodríguez-Sojo, Teresa Vezza, Ivo Pischel, Francesca Algieri, María Elena Rodríguez-Cabezas, Alba Rodríguez-Nogales, Julio Gálvez. Intestinal anti-inflammatory and visceral analgesic effects of a Serpylli herba extract in an experimental model of irritable bowel syndrome in rats. Front. Pharmacol. 2022;13
    https://doi.org/10.3389/fphar.2022.967644
  101. Eamonn M. M. Quigley. Overlapping irritable bowel syndrome and inflammatory bowel disease: less to this than meets the eye?. Therap Adv Gastroenterol 2016;9:199
    https://doi.org/10.1177/1756283X15621230
  102. Hanna Ilchmann-Diounou, Sandrine Menard. Psychological Stress, Intestinal Barrier Dysfunctions, and Autoimmune Disorders: An Overview. Front. Immunol. 2020;11
    https://doi.org/10.3389/fimmu.2020.01823
  103. Sutheera Ratanasirintrawoot, Nipan Israsena. Stem Cells in the Intestine: Possible Roles in Pathogenesis of Irritable Bowel Syndrome. J Neurogastroenterol Motil 2016;22:367
    https://doi.org/10.5056/jnm16023
  104. M. Pescatori, V. Podzemny, L. C. Pescatori, M. P. Dore, G. Bassotti. The PNEI holistic approach in coloproctology. Tech Coloproctol 2015;19:269
    https://doi.org/10.1007/s10151-015-1277-6
  105. Soo In Choi, Nayoung Kim, Ryoung Hee Nam, Jae Young Jang, Eun Hye Kim, SungChan Ha, Kisung Kang, Wonseok Lee, HyeLim Choi, Yeon-Ran Kim, Yeong-Jae Seok, Cheol Min Shin, Dong Ho Lee. The Protective Effect of Roseburia faecis Against Repeated Water Avoidance Stress-induced Irritable Bowel Syndrome in a Wister Rat Model. J Cancer Prev 2023;28:93
    https://doi.org/10.15430/JCP.2023.28.3.93
  106. Carolina Barragán-Martínez, Cesar A. Speck-Hernández, Gladis Montoya-Ortiz, Rubén D. Mantilla, Juan-Manuel Anaya, Adriana Rojas-Villarraga, Sudha Chaturvedi. Organic Solvents as Risk Factor for Autoimmune Diseases: A Systematic Review and Meta-Analysis. PLoS ONE 2012;7:e51506
    https://doi.org/10.1371/journal.pone.0051506
  107. Ibtissem Ghouzali, Saïda Azhar, Christine Bôle-Feysot, Philippe Ducrotté, Pierre Déchelotte, Moïse Coëffier. Proteasome inhibitors exacerbate interleukin-8 production induced by protease-activated receptor 2 in intestinal epithelial cells. Cytokine 2016;86:41
    https://doi.org/10.1016/j.cyto.2016.07.014
  108. Yasunori Yamamoto, Shinya Furukawa, Teruki Miyake, Junichi Watanabe, Aki Kato, Katsunori Kusumoto, Eiji Takeshita, Yoshio Ikeda, Naofumi Yamamoto, Yuka Saeki, Yoichi Hiasa. Exercise habits that include exercise partners and irritable bowel syndrome in a young Japanese population: a cross-sectional study. 2023;35:641
    https://doi.org/10.1097/MEG.0000000000002561
  109. Mark L. Dreher. Dietary Fiber in Health and Disease. 2023.
    https://doi.org/10.1007/978-3-319-50557-2_6
  110. Beatriz Gras, Suma Magge, Andrea Bloom, Anthony Lembo. Motility disorders of the colon and rectum. Current Opinion in Gastroenterology 2013;29:66
    https://doi.org/10.1097/MOG.0b013e32835a80e7
  111. Youhe Wu, Yuetong Li, Qi Zheng, Lanjuan Li. The Efficacy of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Nutrients 2024;16:2114
    https://doi.org/10.3390/nu16132114
  112. Simona Deiana, Tommaso Gabbani, Siro Bagnoli, Vito Annese. Emerging drug for diarrhea predominant irritable bowel syndrome. Expert Opinion on Emerging Drugs 2015;20:247
    https://doi.org/10.1517/14728214.2015.1013935
  113. Mihaela Fadgyas-Stanculete, Ana-Maria Buga, Aurel Popa-Wagner, Dan L Dumitrascu. The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations. J Mol Psychiatr 2014;2
    https://doi.org/10.1186/2049-9256-2-4
  114. Marco Soncini, Cristina Stasi, Paolo Usai Satta, Giuseppe Milazzo, Margherita Bianco, Gioacchino Leandro, Luigi Maria Montalbano, Nicola Muscatiello, Fabio Monica, Francesca Galeazzi, Massimo Bellini, Maurizio Carrara, Francesco Cabras, Vito Guerra, Salvatore Camilleri, Dario Gambaccini, Leonardo Tammaro, Lucia D’Alba, Luigi Turco, Paolo Gasparini, Attilio Solinas, Giovanni Russo, Andrea Pancetti, Beatrice Salvioli, Andrea Anderloni, Gabrio Bassotti, Maria Antonia Lai, Matteo Antonino, Manuela De Bona, Sandro Boschetto, Silvia Rentini, Piera Rossitti, Eugenio Limido, Antonio Balzano. IBS clinical management in Italy: The AIGO survey. Digestive and Liver Disease 2019;51:782
    https://doi.org/10.1016/j.dld.2018.10.006
  115. Fanny Söderquist, Mikaela Syk, David Just, Zorana Kurbalija Novicic, Annica J. Rasmusson, Per M. Hellström, Mia Ramklint, Janet L. Cunningham. A cross-sectional study of gastrointestinal symptoms, depressive symptoms and trait anxiety in young adults. BMC Psychiatry 2020;20
    https://doi.org/10.1186/s12888-020-02940-2
  116. Julia König, Ignacio Rangel, Robert J. Brummer. The Role of Lactic Acid Bacteria in the Pathophysiology and Treatment of Irritable Bowel Syndrome (IBS). FNS 2013;04:27
    https://doi.org/10.4236/fns.2013.411A005
  117. Michael P. Jones, Ayesha Shah, Marjorie M. Walker, Natasha A. Koloski, Gerald Holtmann, Nicholas J. Talley. Antibiotic use but not gastrointestinal infection frequently precedes first diagnosis of functional gastrointestinal disorders. UEG Journal 2021;9:1074
    https://doi.org/10.1002/ueg2.12164
  118. Malaksima Ayadilord, Sara Mahmoudzadeh, Zahra Sadat Hoseini, Masoumeh Askari, Hadis Rezapour, Mansoore Saharkhiz, Arefeh Abbaszadeh, Samira Karbasi, Nasrin Zandi Dashtebayaze, Gordon A. Ferns, Afsane Bahrami. Neuropsychological function is related to irritable bowel syndrome in women with premenstrual syndrome and dysmenorrhea. Arch Gynecol Obstet 2020;302:915
    https://doi.org/10.1007/s00404-020-05659-3
  119. Sihao Zhang, Danmei Tian, Zixuan Xia, Fengge Yang, Yanhui Chen, Zhihong Yao, Yi He, Xinglong Miao, Guirong Zhou, Xinsheng Yao, Jinshan Tang. Chang-Kang-Fang alleviates diarrhea predominant irritable bowel syndrome (IBS-D) through inhibiting TLR4/NF-κB/NLRP3 pathway. Journal of Ethnopharmacology 2024;330:118236
    https://doi.org/10.1016/j.jep.2024.118236
  120. Juliet E. Compston. Risk of osteoporotic fractures in irritable bowel syndrome. Nat Rev Endocrinol 2013;9:8
    https://doi.org/10.1038/nrendo.2012.216
  121. Sigrid Elsenbruch, Sven Benson. The Senses: A Comprehensive Reference. 2013.
    https://doi.org/10.1016/B978-0-12-805408-6.00019-1
  122. Molly Duffy, Victoria L. Boggiano, Ravindra Ganesh, Michael Mueller. Functional Gastrointestinal Disorders. Primary Care: Clinics in Office Practice 2023;50:429
    https://doi.org/10.1016/j.pop.2023.03.006
  123. Priya Hattay, Dawn K. Prusator, Anthony C. Johnson, Beverley Greenwood-Van Meerveld. Stereotaxic Exposure of the Central Nucleus of the Amygdala to Corticosterone Increases Colonic Permeability and Reduces Nerve-Mediated Active Ion Transport in Rats. Front. Neurosci. 2018;12
    https://doi.org/10.3389/fnins.2018.00543
  124. Ida Hilmi, Juanda Leo Hartono, Jayalakshmi Pailoor, Sanjiv Mahadeva, Khean-Lee Goh. Low prevalence of ‘classical’ microscopic colitis but evidence of microscopic inflammation in Asian Irritable Bowel Syndrome patients with diarrhoea. BMC Gastroenterol 2013;13
    https://doi.org/10.1186/1471-230X-13-80
  125. P. Hattay, D. K. Prusator, L. Tran, B. Greenwood‐Van Meerveld. Psychological stress‐induced colonic barrier dysfunction: Role of immune‐mediated mechanisms. Neurogastroenterology Motil 2017;29
    https://doi.org/10.1111/nmo.13043
  126. Sigrid Elsenbruch. Reference Module in Neuroscience and Biobehavioral Psychology. 2017.
    https://doi.org/10.1016/B978-0-12-809324-5.00019-5
  127. Lai Wei, Rajan Singh, Uday C Ghoshal. Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction. J Neurogastroenterol Motil 2022;28:357
    https://doi.org/10.5056/jnm22008
  128. J. König, R.J. Brummer. Alteration of the intestinal microbiota as a cause of and a potential therapeutic option in irritable bowel syndrome. BM 2014;5:247
    https://doi.org/10.3920/BM2013.0033
  129. Rajdeep Singh, Ahmed Salem, Julie Nanavati, Gerard E. Mullin. The Role of Diet in the Treatment of Irritable Bowel Syndrome. Gastroenterology Clinics of North America 2018;47:107
    https://doi.org/10.1016/j.gtc.2017.10.003
  130. Jee-Yon Lee, Sang-Hui Chu, Justin Y. Jeon, Mi-Kyung Lee, Ji-Hye Park, Duk-Chul Lee, Ji-Won Lee, Nam-Kyu Kim. Effects of 12 weeks of probiotic supplementation on quality of life in colorectal cancer survivors: A double-blind, randomized, placebo-controlled trial. Digestive and Liver Disease 2014;46:1126
    https://doi.org/10.1016/j.dld.2014.09.004
  131. Elemer Simon, Lavinia Florina Călinoiu, Laura Mitrea, Dan Cristian Vodnar. Probiotics, Prebiotics, and Synbiotics: Implications and Beneficial Effects against Irritable Bowel Syndrome. Nutrients 2021;13:2112
    https://doi.org/10.3390/nu13062112
  132. Emanuele Sinagra, Giancarlo Pompei, Giovanni Tomasello, Francesco Cappello, Gaetano Cristian Morreale, Georgios Amvrosiadis, Francesca Rossi, Attilio Ignazio Lo Monte, Aroldo Gabriele Rizzo, Dario Raimondo. Inflammation in irritable bowel syndrome: Myth or new treatment target?. WJG 2016;22:2242
    https://doi.org/10.3748/wjg.v22.i7.2242
  133. Jintao Fang, Weihan Zhu, Dian Yu, Lujian Zhu, Haorui Zha, Jingyi Tang, Yujia Li, Xiaxin Zhu, Ting Zhao, Wei Zhang. From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases — Opportunity or Challenge?. JIR 2025;Volume 18:3349
    https://doi.org/10.2147/JIR.S498703
  134. Jareth Jun Jie Ng, Wai Mun Loo, Kewin Tien Ho Siah. Associations between irritable bowel syndrome and non-alcoholic fatty liver disease: A systematic review. World J Hepatol 2023;15:925
    https://doi.org/10.4254/wjh.v15.i7.925
  135. Antonio Carroccio, Pasquale Mansueto, Giuditta Morfino, Alberto D'Alcamo, Valentina Di Paola, Giuseppe Iacono, Maurizio Soresi, Gregorio Scerrino, Emiliano Maresi, Gaspare Gulotta, GiovamBattista Rini, Sebastiano Bonventre. Oligo-Antigenic Diet in the Treatment of Chronic Anal Fissures. Evidence for a Relationship Between Food Hypersensitivity and Anal Fissures. 2013;108:825
    https://doi.org/10.1038/ajg.2013.58
  136. Karlo Toljan, Bruce Vrooman. Psychoneuroimmunological approach to gastrointestinal related pain. 2017;17:431
    https://doi.org/10.1016/j.sjpain.2017.10.010
  137. Emanuele Sinagra, Gaetano Cristian Morreale, Ghazaleh Mohammadian, Giorgio Fusco, Valentina Guarnotta, Giovanni Tomasello, Francesco Cappello, Francesca Rossi, Georgios Amvrosiadis, Dario Raimondo. New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond. WJG 2017;23:6593
    https://doi.org/10.3748/wjg.v23.i36.6593
  138. Ju Yup Lee, Nayoung Kim, Ryoung Hee Nam, Sung Hwa Sohn, Sun Min Lee, Daeun Choi, Hyuk Yoon, Yong Sung Kim, Hye Seung Lee, Dong Ho Lee, Seungil Ro. Probiotics reduce repeated water avoidance stress-induced colonic microinflammation in Wistar rats in a sex-specific manner. PLoS ONE 2017;12:e0188992
    https://doi.org/10.1371/journal.pone.0188992
  139. Jasmine R. Cleminson, Julie A. Pasco, Chiara C. Bortolasci, Kara L. Holloway-Kew, Jason M. Hodge, Kara B. Anderson, Mark A. Kotowicz, Rasika M. Samarasinghe, Lana J. Williams. Lipopolysaccharide-binding protein and bone health: data from a population-based sample of men. Osteoporos Int 2023;34:309
    https://doi.org/10.1007/s00198-022-06602-9
  140. Giovanni Barbara, Cesare Cremon, Vincenzo Stanghellini. Inflammatory bowel disease and irritable bowel syndrome. Current Opinion in Gastroenterology 2014;30:352
    https://doi.org/10.1097/MOG.0000000000000070
  141. Ju Yup Lee, Nayoung Kim, Yong Sung Kim, Ryoung Hee Nam, Min Hee Ham, Hye Seung Lee, Wonjun Jo, Youngkwang Shim, Yoon Jin Choi, Hyuk Yoon, Cheol Min Shin, Dong Ho Lee. Repeated Water Avoidance Stress Alters Mucosal Mast Cell Counts, Interleukin-1β Levels with Sex Differences in the Distal Colon of Wistar Rats. J Neurogastroenterol Motil 2016;22:694
    https://doi.org/10.5056/jnm16007
  142. Beverley Greenwood-Van Meerveld, Anthony C Johnson. Mechanisms of Stress-induced Visceral Pain. J Neurogastroenterol Motil 2018;24:7
    https://doi.org/10.5056/jnm17137
  143. Adrian Catinean, Adriana Maria Neag, Andreea Nita, Mihaela Buzea, Anca Dana Buzoianu. Bacillus spp. Spores—A Promising Treatment Option for Patients with Irritable Bowel Syndrome. Nutrients 2019;11:1968
    https://doi.org/10.3390/nu11091968
  144. G. Di Nardo, G. Barbara, S. Cucchiara, C. Cremon, R. J. Shulman, S. Isoldi, L. Zecchi, L. Drago, S. Oliva, R. Saulle, M. R. Barbaro, L. Stronati. Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS. Neurogastroenterology Motil 2014;26:196
    https://doi.org/10.1111/nmo.12250
  145. Edwin K. McDonald, Heather Rasmussen, Christopher Forsyth, Ali Keshavarzian. Functional Foods and Beverages. 2014.
    https://doi.org/10.1002/9781118823309.ch2
  146. Yong Hwan Kwon, Hyun Jin Kim. Current Status of Translational Research on Irritable Bowel Syndrome. Korean J Gastroenterol 2016;68:138
    https://doi.org/10.4166/kjg.2016.68.3.138
  147. Jeong Eun Shin. Dose Irritable Bowel Syndrome and Dysmotility Have an Autoimmune Origin? (Neurogastroenterol Motil 2011;23:1000-1006, e459). J Neurogastroenterol Motil 2012;18:104
    https://doi.org/10.5056/jnm.2012.18.1.104
  148. Stephan C Bischoff, Giovanni Barbara, Wim Buurman, Theo Ockhuizen, Jörg-Dieter Schulzke, Matteo Serino, Herbert Tilg, Alastair Watson, Jerry M Wells. Intestinal permeability – a new target for disease prevention and therapy. BMC Gastroenterol 2014;14
    https://doi.org/10.1186/s12876-014-0189-7
  149. Rosario Cuomo, Giovanni Barbara, Fabio Pace, Vito Annese, Gabrio Bassotti, Gian Andrea Binda, Tino Casetti, Antonio Colecchia, Davide Festi, Roberto Fiocca, Andrea Laghi, Giovanni Maconi, Riccardo Nascimbeni, Carmelo Scarpignato, Vincenzo Villanacci, Bruno Annibale. Italian consensus conference for colonic diverticulosis and diverticular disease. UEG Journal 2014;2:413
    https://doi.org/10.1177/2050640614547068
  150. Lei Zhang, Jun Song, Xiaohua Hou. Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside. J Neurogastroenterol Motil 2016;22:181
    https://doi.org/10.5056/jnm15137
  151. Erica Sande Teige, Urd Sortvik, Gülen Arslan Lied. A Systematic Review: Fecal Bacterial Profile in Patients with Irritable Bowel Syndrome Analyzed with the GA-Map Dysbiosis Test Based on the 16S rRNA Gene of Bacterial Species or Groups. CEG 2024;Volume 17:109
    https://doi.org/10.2147/CEG.S451675
  152. C. H. Choi, J. G. Kwon, S. K. Kim, S.‐J. Myung, K. S. Park, C.‐I. Sohn, P.‐L. Rhee, K. J. Lee, O. Y. Lee, H.‐K. Jung, S. R. Jee, Y. T. Jeen, M.‐G. Choi, S. C. Choi, K. C. Huh, H. Park. Efficacy of combination therapy with probiotics and mosapride in patients with IBS without diarrhea: a randomized, double‐blind, placebo‐controlled, multicenter, phase II trial. Neurogastroenterology Motil 2015;27:705
    https://doi.org/10.1111/nmo.12544
  153. Ming Xia. Visceral Pain. 2015.
    https://doi.org/10.1007/978-981-99-9167-9_11
  154. Céline Deraison, Nathalie Vergnolle. Pharmacology of Intestinal Inflammation and Repair. 2025;65:301
    https://doi.org/10.1146/annurev-pharmtox-051921-084536
  155. Sunil Kumar, Ratnakar Shukla, Prabhat Ranjan, Awanish Kumar. Interleukin-10: A Compelling Therapeutic Target in Patients With Irritable Bowel Syndrome. Clinical Therapeutics 2017;39:632
    https://doi.org/10.1016/j.clinthera.2017.01.030
  156. Piplu Bhuiyan, Mamun Al Mahtab, Sheikh Mohammad Fazle Akbar. Unrevealing of dysregulated hub genes linked with immune system and inflammatory signaling pathways in the pathogenesis of irritable bowel syndrome by system biology approaches. Informatics in Medicine Unlocked 2023;39:101241
    https://doi.org/10.1016/j.imu.2023.101241