• Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases

    Comparison of mechanisms of action of lansoprazole (conventional proton pump inhibitor) and vonoprazan (potassium-competitive acid blocker). Hydrogen potassium (H+, K+)-ATPases are located in tubulovesicles in quiescent phase and appear on the apical membrane of secretory canaliculus in the active phase, which occurs after a meal. Lansoprazole converts to its active form in the secretory canaliculus, though it degrades soon after (X). The active form of lansoprazole covalently binds to H+, K+-ATPase (proton pump). Vonoprazan stably accumulates in the acidic secretory canaliculus and non-covalently binds to H+, K+-ATPase with very a very slow dissociation rate and can inhibit newly exposed H+, K+-ATPase for a long time.

  • Role of the Duodenum in the Pathogenesis of Functional Dyspepsia: A Paradigm Shift

    Low-grade duodenal inflammation in the etiopathogenesis of functional dyspepsia.

  • Pharmabiotic Manipulation of the Microbiota in Gastrointestinal Disorders: A Clinical Perspective

    Engagement between the gut immune system and a probiotic (exemplified by Bifidobacterium longum subsp. longum 35624) leads to a regulatory T-cell response. 1. Rather than initiating an inflammatory response via the nuclear factor-kappa B (NF-κB) pathway, B. longum subsp. longum 35624 engages with dendritic cells (DCs) through toll-like receptors (TLR) 2 and 6. 2. This does not lead to the release of inflammatory cytokines such as TNF-α and IL-12 which would typify engagement with a pathogen. 3. Instead, engagement with B. longum subsp. infantis 35624 leads to the secretion of the anti-inflammatory cytokines IL-10 and TGF-β and the stimulation of regulatory T-cells. 4. Engagement of B. longum subsp. infantis 35624 via TLR-9 also stimulates IL-10 secretion and regulatory T-cell proliferation. CCL-20, chemokine (C-C motif) ligand 20; CLR, C-type lectin receptors; DC-SIGN, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; MDC, myeloid-derived dendritic cells; PDC, plasmacytoid dendritic cells. Modified from Konieczna et al with permission.

  • Anorectal Manometry in Defecatory Disorders: A Comparative Analysis of High-resolution Pressure Topography and Waveform Manometry

    The 4 types (I–IV) of dyssynergic defecation patterns (A) previously described by Rao et al and Rao and Singh are illustrated in conventional lines and color topographic forms. (B) The 3 defecatory subtypes based on principal components analysis recently described by Ratuapli et al, ie, [a] high anal, [b] hybrid, and [c] low rectal.


Journal of Neurogastroenterology and Motility 2018; 24(3): 329~506 Total PDF
Editorials
Which Provocation Test Will Be Added to Routine High-resolution Manometry Protocol in Unexplained Dysphagia?
Yu Kyung Cho
Journal of Neurogastroenterology and Motility 2018; 24(3): 329-330  https://doi.org/10.5056/jnm18111
Is High-resolution Anorectal Pressure Topography More Useful Than Wave Manometry in Dyssynergic Defecation?
Tae Hee Lee
Journal of Neurogastroenterology and Motility 2018; 24(3): 331-333  https://doi.org/10.5056/jnm18105
Reviews
Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases
Tadayuki Oshima, and Hiroto Miwa
Journal of Neurogastroenterology and Motility 2018; 24(3): 334-344  https://doi.org/10.5056/jnm18029
Role of the Duodenum in the Pathogenesis of Functional Dyspepsia: A Paradigm Shift
Hye-kyung Jung, and Nicholas J Talley
Journal of Neurogastroenterology and Motility 2018; 24(3): 345-354  https://doi.org/10.5056/jnm18060
Pharmabiotic Manipulation of the Microbiota in Gastrointestinal Disorders: A Clinical Perspective
Fanny Giron, and Eamonn M M Quigley
Journal of Neurogastroenterology and Motility 2018; 24(3): 355-366  https://doi.org/10.5056/jnm18004
Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders
Hirokazu Fukui, Xin Xu, and Hiroto Miwa
Journal of Neurogastroenterology and Motility 2018; 24(3): 367-386  https://doi.org/10.5056/jnm18071
Original Articles
Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry
Michael C Bennett, Amit Patel, Nitin Sainani, Dan Wang, Gregory S Sayuk, and C Prakash Gyawali
Journal of Neurogastroenterology and Motility 2018; 24(3): 387-394  https://doi.org/10.5056/jnm17126
Abnormal Bolus Reflux Is Associated With Poor Pulmonary Outcome in Patients With Idiopathic Pulmonary Fibrosis
Lawrence F Borges, Vikrant Jagadeesan, Hilary Goldberg, Sravanya Gavini, Wai-Kit Lo, Robert Burakoff, Natan Feldman, and Walter W Chan
Journal of Neurogastroenterology and Motility 2018; 24(3): 395-402  https://doi.org/10.5056/jnm18023
Esophagography in Patients With Esophageal Achalasia Diagnosed With High-resolution Esophageal Manometry
Takahisa Yamasaki, Toshihiko Tomita, Sumire Mori, Mayu Takimoto, Akio Tamura, Ken Hara, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Jiro Watari, and Hiroto Miwa
Journal of Neurogastroenterology and Motility 2018; 24(3): 403-409  https://doi.org/10.5056/jnm17147
200 mL Rapid Drink Challenge During High-resolution Manometry Best Predicts Objective Esophagogastric Junction Obstruction and Correlates With Symptom Severity
Philip Woodland, Shirley Gabieta-Sonmez, Julieta Arguero, Joanne Ooi, Kenichiro Nakagawa, Esteban Glasinovic, Etsuro Yazaki, and Daniel Sifrim
Journal of Neurogastroenterology and Motility 2018; 24(3): 410-414  https://doi.org/10.5056/jnm18038
Cytokine Profile and Immunoglobulin E-mediated Serological Food Hypersensitivity in Patients With Irritable Bowel Syndrome With Diarrhea
Ryo Katsumata, Manabu Ishii, Suni Lee, Yukiko Handa, Takahisa Murao, Minoru Fujita, Hiroshi Matsumoto, Takemi Otsuki, and Akiko Shiotani
Journal of Neurogastroenterology and Motility 2018; 24(3): 415-421  https://doi.org/10.5056/jnm17114
Dysregulation of GABAergic Signalling Contributes in the Pathogenesis of Diarrhea-predominant Irritable Bowel Syndrome
Surbhi Aggarwal, Vineet Ahuja, and Jaishree Paul
Journal of Neurogastroenterology and Motility 2018; 24(3): 422-430  https://doi.org/10.5056/jnm17100
Evaluation of 153 Asymptomatic Subjects Using the Anopress Portable Anal Manometry Device
Cosimo Alex Leo, Emanuel Cavazzoni, Gregory P Thomas, Jonathan Hodgkison, Jamie Murphy, and Carolynne J Vaizey
Journal of Neurogastroenterology and Motility 2018; 24(3): 431-436  https://doi.org/10.5056/jnm17135
Use of Dietary Management in Irritable Bowel Syndrome: Results of a Survey of Over 1500 United States Gastroenterologists
Adrienne Lenhart, Courtney Ferch, Michael Shaw, and William D Chey
Journal of Neurogastroenterology and Motility 2018; 24(3): 437-451  https://doi.org/10.5056/jnm17116
Effects of the Administration of Probiotics on Fecal Microbiota Diversity and Composition in Healthy Individuals
Choong-Kyun Noh, Bong Sun Kim, Gana Hong, Jae Youn Cheong, and Kwang Jae Lee
Journal of Neurogastroenterology and Motility 2018; 24(3): 452-459  https://doi.org/10.5056/jnm17140
Anorectal Manometry in Defecatory Disorders: A Comparative Analysis of High-resolution Pressure Topography and Waveform Manometry
Yeong Yeh Lee, Askin Erdogan, Siegfried Yu, Annie Dewitt, and Satish S C Rao
Journal of Neurogastroenterology and Motility 2018; 24(3): 460-468  https://doi.org/10.5056/jnm17081
Relation of Enteric α-Synuclein to Gastrointestinal Dysfunction in Patients With Parkinson’s Disease and in Neurologically Intact Subjects
Hyo Jeong Lee, Kee Wook Jung, Sun Ju Chung, Seung-Mo Hong, Juyeon Kim, Jeong Hoon Lee, Sung Wook Hwang, Ho-Sung Ryu, Mi Jung Kim, Ho-Su Lee, Myeongsook Seo, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Jaewon Choe, Hwoon-Yong Jung, Suk-Kyun Yang, and Seung-Jae Myung
Journal of Neurogastroenterology and Motility 2018; 24(3): 469-478  https://doi.org/10.5056/jnm17141
Effects of Fengliao-Changweikang in Diarrhea-predominant Irritable Bowel Syndrome Rats and Its Mechanism Involving Colonic Motility
Mengdi Jia, Xiaofang Lu, Zhengfang Wang, Luqing Zhao, and Shengsheng Zhang
Journal of Neurogastroenterology and Motility 2018; 24(3): 479-489  https://doi.org/10.5056/jnm17093
The Protective Effect of Melissa officinalis L. in Visceral Hypersensitivity in Rat Using 2 Models of Acid-induced Colitis and Stress-induced Irritable Bowel Syndrome: A Possible Role of Nitric Oxide Pathway
Fatemeh Dolatabadi, Amir H Abdolghaffari, Mohammad H Farzaei, Maryam Baeeri, Fatemeh S Ziarani, Majid Eslami, Mohammad Abdollahi, and Roja Rahimi
Journal of Neurogastroenterology and Motility 2018; 24(3): 490-501  https://doi.org/10.5056/jnm17035
Letter to the Editor
Response to Treatment of Helicobacter pylori-associated Dyspepsia: Eradication of Helicobacter pylori or Correction of Gastric or Intestinal Dysbiosis?
Philip Abraham, and Verima Pereira
Journal of Neurogastroenterology and Motility 2018; 24(3): 502-502  https://doi.org/10.5056/jnm18091
Rumination Syndrome: Unknown Pathology Easy to Diagnose With High-resolution Impedance Manometry
Esperanza Martos Vizcaino, Fernando Canga Rodriguez-Valcárcel, and Constanza Ciriza de Los Ríos
Journal of Neurogastroenterology and Motility 2018; 24(3): 503-505  https://doi.org/10.5056/jnm18048
Corrigenda & Errata
Corrigendum
Journal of Neurogastroenterology and Motility 2018; 24(3): 506-506  https://doi.org/10.5056/jnm24031

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Current Issue

July 2018
Volume 24
Issue 3
  • News & Notice
  • Chul-Hyun Lim
    Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Jae Hak Kim
    Department of Internal Medicine, Ilsan Hospital, Dongguk University, Goyang, Korea
  • Uday C Ghoshal
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Sutep Gonlachanvit
    Center of Excellence on Neurogastroenterology and Motility, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
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