• Mechanisms of Stress-induced Visceral Pain

    Amygdala-mediated mechanisms for stress-induced colonic hypersensitivity. The body’s neuroendocrine stress response (hypothalamic-pituitary-adrenal [HPA] axis) is initiated at the hypothalamus and causes the synthesis and release of corticotropin-releasing hormone (CRH) onto the anterior pituitary. Upon binding of CRH to its type 1 receptor, the pituitary gland secretes adrenocorticotropic hormone (ACTH) into the peripheral blood circulation leading to production of cortisol in humans or corticosterone (CORT) in rodents. Following release into the circulation, CORT binds to the glucocorticoid receptor (GR) to initiate negative feedback of the HPA axis at the level of the hypothalamus and the hippocampus. In contrast, CORT binding to GR at the amygdala leads to facilitation of HPA axis, thus promoting persistent stress activation.,– In this review, we discuss our recent data showing that stress activation or implantation of a CORT micropellet at the amygdala produces persistent colonic hypersensitivity to balloon distension along with decreased GR expression and increased CRH expression.– Our findings have also revealed that a decrease in GR expression could be due to increased methylation (Me) of the GR promoter along with decreased acetylation (Ac) of histone 3 (H3) at the GR promoter., The persistent decrease in GR expression decreases the binding of GR to a negative GR response (nGRE) element in the CRH promoter, thus removing GR-induced repression of CRH expression. The loss of the repression of the CRH promoter induced a persistent increase in CRH expression, and inhibiting the increase in CRH expression reversed the stress-induced colonic hypersensitivity.62

  • Esophageal Baseline Impedance Reflects Mucosal Integrity and Predicts Symptomatic Outcome With Proton Pump Inhibitor Treatment

    The comparison of intercellular space diameter (ISD) and mean nocturnal baseline impedance among 3 subgroups and controls. The ISD of patients were larger than that of healthy controls, whether with or without esophagitis (P < 0.05). The baseline impedance in erosive esophagitis (EE) and non-erosive reflux disease (NERD) patients was lower than that in patients with hypersensitive esophagus (HE) and healthy controls (P < 0.05).

  • Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome

    Differential gene expression in irritable bowel syndrome (IBS). A heat map illustrating 858 genetic features with differential expression levels between IBS and asymptomatic populations, with P-values < 0.05 as determined through the Mann-Whitney U test. Color and intensity correlated with the expression patterns for individual biomarkers. Blue is indicative of lower levels of expression while red is indicative of higher levels.

  • Bifidobacterium longum and Lactobacillus helveticus Synergistically Suppress Stress-related Visceral Hypersensitivity Through Hypothalamic-Pituitary-Adrenal Axis Modulation

    Prevention of abdominal pain induced by chronic stress (water avoidance stress [WAS]) depends on the strain probiotic. *P < 0.05 and #P < 0.05 are significantly different from control and WAS groups. B. longum, Bifidobacterium longum; L. helveticus, Lactobacillus helveticus.

  • Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus

    The degree of inflammation in the postoperative ileus (POI) and sham groups. (A) Semi-quantitative analysis of inflammatory cells was done by counting the leukocytes per field under bright field microscopy. Scatter dot plots showed significantly increased expression of inflammation in POI groups compared to sham groups (control, n = 4; sham, n = 4; POI 3-hr, n = 6; POI 6-hr, n = 5). *P < 0.05 was considered to indicate statistical significance compared to the sham groups. (B) Representative hematoxylin and eosin images of the POI and sham groups (×400 magnification).


Journal of Neurogastroenterology and Motility 2018; 24(1): 1~160 Total PDF
Editorials
Can Esophageal Baseline Impedance Predict Proton Pump Inhibitor Response in Gastroesophageal Reflux Disease?
Kyoungwon Jung, and Moo In Park
Journal of Neurogastroenterology and Motility 2018; 24(1): 1-3  https://doi.org/10.5056/jnm17138
Gut Microbiota-Brain Axis Modulation by a Healthier Microbiological Microenvironment : Facts and Fictions
Uday C Ghoshal
Journal of Neurogastroenterology and Motility 2018; 24(1): 4-6  https://doi.org/10.5056/jnm17150
Reviews
Mechanisms of Stress-induced Visceral Pain
Beverley Greenwood-Van Meerveld, and Anthony C Johnson
Journal of Neurogastroenterology and Motility 2018; 24(1): 7-18  https://doi.org/10.5056/jnm17137
Neuromodulation via Interferential Electrical Stimulation as a Novel Therapy in Gastrointestinal Motility Disorders
Judith S Moore, Peter R Gibson, and Rebecca E Burgell
Journal of Neurogastroenterology and Motility 2018; 24(1): 19-29  https://doi.org/10.5056/jnm17071
Gut Microbiota Dysfunction as Reliable Non-invasive Early Diagnostic Biomarkers in the Pathophysiology of Parkinson’s Disease: A Critical Review
Arun T Nair, Vadivelan Ramachandran, Nanjan M Joghee, Shanish Antony, and Gopalakrishnan Ramalingam
Journal of Neurogastroenterology and Motility 2018; 24(1): 30-42  https://doi.org/10.5056/jnm17105
Original Articles
Esophageal Baseline Impedance Reflects Mucosal Integrity and Predicts Symptomatic Outcome With Proton Pump Inhibitor Treatment
Chenxi Xie, Daniel Sifrim, Yuwen Li, Minhu Chen, and Yinglian Xiao
Journal of Neurogastroenterology and Motility 2018; 24(1): 43-50  https://doi.org/10.5056/jnm17032
Is It Useful to Administer Probiotics Together With Proton Pump Inhibitors in Children With Gastroesophageal Reflux?
Oana Belei, Laura Olariu, Andreea Dobrescu, Tamara Marcovici, and Otilia Marginean
Journal of Neurogastroenterology and Motility 2018; 24(1): 51-57  https://doi.org/10.5056/jnm17059
Factors Determining the Inter-observer Variability and Diagnostic Accuracy of High-resolution Manometry for Esophageal Motility Disorders
Ji Hyun Kim, Sung Eun Kim, Yu Kyung Cho, Chul-Hyun Lim, Moo In Park, Jin Won Hwang, Jae-Sik Jang, Minkyung Oh; Motility Study Club of Korean Society of Neurogastroenterology and Motility
Journal of Neurogastroenterology and Motility 2018; 24(1): 58-69  https://doi.org/10.5056/jnm17064
Interest of Anorectal Manometry During Long-term Follow-up of Patients Operated on for Hirschsprung’s Disease
Viet Q Tran, Tania Mahler, Patrick Bontems, Dinh Q Truong, Annie Robert, Philippe Goyens, and Henri Steyaert
Journal of Neurogastroenterology and Motility 2018; 24(1): 70-78  https://doi.org/10.5056/jnm17019
Sexual Abuse Is Associated With an Abnormal Psychological Profile and Sleep Difficulty in Patients With Irritable Bowel Syndrome in Taiwan
Hsing-Feng Lee, Pei-Yi Liu, Yen-Po Wang, Chia-Fen Tsai, Full-Young Chang, and Ching-Liang Lu
Journal of Neurogastroenterology and Motility 2018; 24(1): 79-86  https://doi.org/10.5056/jnm17004
Increased Postprandial Colonic Motility and Autonomic Nervous System Activity in Patients With Irritable Bowel Syndrome: A Prospective Study
Yukari Tanaka, Motoyori Kanazawa, Olafur S Palsson, Miranda A Van Tilburg, Lisa M Gangarosa, Shin Fukudo, Douglas A Drossman, and William E Whitehead
Journal of Neurogastroenterology and Motility 2018; 24(1): 87-95  https://doi.org/10.5056/jnm16216
Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome
Christopher M Dussik, Maryam Hockley, Aleksandra Grozić, Ichiro Kaneko, Lin Zhang, Marya S Sabir, Jin Park, Jie Wang, Cheryl A Nickerson, Steven H Yale, Christopher J Rall, Amy E Foxx-Orenstein, Connie M Borror, Todd R Sandrin, and Peter W Jurutka
Journal of Neurogastroenterology and Motility 2018; 24(1): 96-106  https://doi.org/10.5056/jnm17021
White Matter Microstructural Similarity and Diversity of Functional Constipation and Constipation-predominant Irritable Bowel Syndrome
Jiaofen Nan, Liangliang Zhang, Qiqiang Chen, Nannan Zong, Peiyong Zhang, Xing Ji, Shaohui Ma, Yuchen Zhang, Wei Huang, Zhongzhou Du, Yongquan Xia, and Ming Zhang
Journal of Neurogastroenterology and Motility 2018; 24(1): 107-118  https://doi.org/10.5056/jnm17038
Colorectal Transit and Volume During Treatment With Prolonged-release Oxycodone/Naloxone Versus Oxycodone Plus Macrogol 3350
Jakob L Poulsen, Esben B Mark, Christina Brock, Jens B Frøkjær, Klaus Krogh, and Asbjørn M Drewes
Journal of Neurogastroenterology and Motility 2018; 24(1): 119-127  https://doi.org/10.5056/jnm17058
Regulation of Intracellular Calcium by Endoplasmic Reticulum Proteins in Small Intestinal Interstitial Cells of Cajal
Chan Guk Park, Mei Jin Wu, Chansik Hong, Ju Yeon Jo, Han Yi Jiao, Hyun Park, Jae Yeoul Jun, and Seok Choi
Journal of Neurogastroenterology and Motility 2018; 24(1): 128-137  https://doi.org/10.5056/jnm16212
Bifidobacterium longum and Lactobacillus helveticus Synergistically Suppress Stress-related Visceral Hypersensitivity Through Hypothalamic-Pituitary-Adrenal Axis Modulation
Afifa Ait-Belgnaoui, Isabelle Payard, Claire Rolland, Cherryl Harkat, Viorica Braniste, Vassillia Théodorou, and Thomas A Tompkins
Journal of Neurogastroenterology and Motility 2018; 24(1): 138-146  https://doi.org/10.5056/jnm16167
Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus
Yoo Jin Lee, Zahid Hussain, Cheal Wung Huh, Young Ju Lee, and Hyojin Park
Journal of Neurogastroenterology and Motility 2018; 24(1): 147-158  https://doi.org/10.5056/jnm17012
Letter to the Editor
Symptomatic Non-acidic Reflux in a Patient With Chronic Autoimmune Atrophic Gastritis Successfully Treated With Anti-reflux Surgery
Carlos Teruel, María Jesús de Higes, Patricia Luengo, and Eduardo Lobo
Journal of Neurogastroenterology and Motility 2018; 24(1): 159-160  https://doi.org/10.5056/jnm17083

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Current Issue

January 2018
Volume 24
Issue 1
  • News & Notice
  • Yu Kyung Cho
    Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's hospital, Seoul, Korea
    Jung Ho Park
    Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea
    Tadayuki Oshima
    Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
  • Daniel Sifrim
    Barts and The London School of Medicine and Dentistry Queen Mary, University of London, UK
    Moon Young Lee
    Department of Physiology, Wonkwang Digestive Disease Research Institute and Institute of Wonkwang Medical Science, School of Medicine, Wonkwang University, Iksan, Korea
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