• Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten?

    Putative mechanisms for symptom generation by wheat components. CD, celiac disease; FODMAPs, fermentable oligo-, di-, and mono-saccharides and polyols; ATIs, α-amylase/trypsin inhibitors; IBS, irritable bowel syndrome; GI, gastrointestinal; TLR-4, toll-like-receptor-4; NCWS, non-celiac wheat sensitivity; NCGS, non-celiac gluten sensitivity.

  • The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

    Pharmacological targets of novel drugs for the management of visceral hypersensitivity (VH) in irritable bowel syndrome (IBS). TLRs, Toll-like receptors; PGE2, prostaglandin E2; IL-1β, interleukin-1β; H1-R, histamine-1 receptor; 5-HT, 5-hydrodytryptamine; TRPV1, transient receptor potential vanilloid type I; PKA, cAMP-dependent protein kinase; PKC, protein kinase C; ZO-1, Zona occludens protein-1; NK, neuro-kinin; NGF, nerve growth factor; Trk, tyrosine receptor kinase; VG-Cs, voltage-gated channels; KC, potassium channel; CaC, calcium channel; NaC, sodium channel; NERT, norepinephrine reuptake transporter; NMDA, N-methyl-D-aspartate; AMPA, α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; PAR, protease-activated receptors; R, receptor.

  • Sex and Gender Differences in Gastroesophageal Reflux Disease

    Flow chart documenting the results of search strategy.

  • Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review

    Mechanisms of probiotic effects on the central nervous system. Probiotics influence central nervous system (CNS) function through direct and indirect mechanisms. Probiotics affect the hypothalamic-pituitary-adrenal (HPA) axis, by altering corticosteroid (CORT) and/or adrenocorticotropic hormone (ACTH) levels. The immune system is influenced by limited pro-inflammatory cytokine production and inflammation, and this, in turn, has effects on the CNS. Probiotics can also directly alter CNS biochemistry, such as by affecting brain-derived neurotrophic factor (BDNF), c-Fos, γ-aminobutyric acid (GABA), 5 hydroxytryptamine (5-HT), and dopamine (DA) levels, thus influencing mind and behavior. The vagus and enteric nerves are also involved in this gut-brain interaction and are affected by certain probiotics. Probiotics manipulate the gut microbiota (GM) by increasing microbiota diversity and beneficial bacteria composition. An “improved” GM changes metabolites, such as short-chain fatty acids (SCFAs) and tryptophan, and so improves CNS function indirectly. The GM also interacts with the endocrine, immune, and neural systems.


Journal of Neurogastroenterology and Motility 2016; 22(4): 543~711
Editorials
Symptomatic Improvement of Gastroparesis with Granisetron Transdermal System
Hye-Kyung Jung
Journal of Neurogastroenterology and Motility 2016; 22(4): 543-544  https://doi.org/10.5056/jnm16150
Irritable Inflammatory Bowel Syndrome as a Distinct Disease Entity
Jung Hwan Oh
Journal of Neurogastroenterology and Motility 2016; 22(4): 545-546  https://doi.org/10.5056/jnm16157
Reviews
Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten?
Umberto Volta, Maria Ines Pinto-Sanchez, Elisa Boschetti, Giacomo Caio, Roberto De Giorgio, and Elena F Verdu
Journal of Neurogastroenterology and Motility 2016; 22(4): 547-557  https://doi.org/10.5056/jnm16069
The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments
Mohammad H Farzaei, Roodabeh Bahramsoltani, Mohammad Abdollahi, and Roja Rahimi
Journal of Neurogastroenterology and Motility 2016; 22(4): 558-574  https://doi.org/10.5056/jnm16001
Sex and Gender Differences in Gastroesophageal Reflux Disease
Young Sun Kim, Nayoung Kim, and Gwang Ha Kim
Journal of Neurogastroenterology and Motility 2016; 22(4): 575-588  https://doi.org/10.5056/jnm16138
Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review
Huiying Wang, In-Seon Lee, Christoph Braun, and Paul Enck
Journal of Neurogastroenterology and Motility 2016; 22(4): 589-605  https://doi.org/10.5056/jnm16018
Original Articles
Role of Mixed Reflux and Hypomotility with Delayed Reflux Clearance in Patients with Non-cardiac Chest Pain
Mentore Ribolsi, Paola Balestrieri, Dario Biasutto, Sara Emerenziani, and Michele Cicala
Journal of Neurogastroenterology and Motility 2016; 22(4): 606-612  https://doi.org/10.5056/jnm15182
Per Oral Endoscopic Myotomy in Children with Achalasia Cardia
Zaheer Nabi, Mohan Ramchandani, D Nageshwar Reddy, Santosh Darisetty, Rama Kotla, Rakesh Kalapala, and Radhika Chavan
Journal of Neurogastroenterology and Motility 2016; 22(4): 613-619  https://doi.org/10.5056/jnm15172
Liquid-containing Refluxes and Acid Refluxes May Be Less Frequent in the Japanese Population Than in Other Populations: Normal Values of 24-hour Esophageal Impedance and pH Monitoring
Osamu Kawamura, Yukie Kohata, Noriyuki Kawami, Hiroshi Iida, Akiyo Kawada, Hiroko Hosaka, Yasuyuki Shimoyama, Shiko Kuribayashi, Yasuhiro Fujiwara, Katsuhiko Iwakiri, Masahiko Inamori, Motoyasu Kusano, and Micho Hongo
Journal of Neurogastroenterology and Motility 2016; 22(4): 620-629  https://doi.org/10.5056/jnm15195
Esophageal Acid Clearance During Random Swallowing Is Faster in Patients with Barrett’s Esophagus Than in Healthy Controls
Christian Lottrup, Anne L Krarup, Hans Gregersen, Per Ejstrud, and Asbjørn M Drewes
Journal of Neurogastroenterology and Motility 2016; 22(4): 630-642  https://doi.org/10.5056/jnm16019
Gastric Electrical Stimulation Is an Option for Patients with Refractory Cyclic Vomiting Syndrome
Inderpreet Grover, Richard Kim, Danielle C Spree, Christopher J Lahr, Archana Kedar, Shivangi Kothari, David Fleisher, and Thomas L Abell
Journal of Neurogastroenterology and Motility 2016; 22(4): 643-649  https://doi.org/10.5056/jnm15135
Granisetron Transdermal System for Treatment of Symptoms of Gastroparesis: A Prescription Registry Study
Deena Midani, and Henry P Parkman
Journal of Neurogastroenterology and Motility 2016; 22(4): 650-655  https://doi.org/10.5056/jnm15203
A New Approach to the Prophylaxis of Cyclic Vomiting: Topiramate
Oya B Sezer, and Taner Sezer
Journal of Neurogastroenterology and Motility 2016; 22(4): 656-660  https://doi.org/10.5056/jnm16035
Prevalence of Irritable Bowel Syndrome?like Symptoms in Japanese Patients with Inactive Inflammatory Bowel Disease
Toshihiko Tomita, Yu Kato, Mayu Takimoto, Takahisa Yamasaki, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Yoko Yokoyama, Hisatomo Ikehara, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Shigemi Tanaka, Masayuki Shima, Jiro Watari, and Hiroto Miwa
Journal of Neurogastroenterology and Motility 2016; 22(4): 661-669  https://doi.org/10.5056/jnm15160
Prevalence of Irritable Bowel Syndrome in Singapore and Its Association with Dietary, Lifestyle, and Environmental Factors
Kewin T H Siah, Reuben K Wong, Yiong H Chan, Khek Y Ho, and Kok-Ann Gwee
Journal of Neurogastroenterology and Motility 2016; 22(4): 670-676  https://doi.org/10.5056/jnm15148
Prevalence and Self-recognition of Chronic Constipation: Results of an Internet Survey
Akio Tamura, Toshihiko Tomita, Tadayuki Oshima, Fumihiko Toyoshima, Takahisa Yamasaki, Takuya Okugawa, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Hisatomo Ikehara, Yoshio Ohda, Hirokazu Fukui, Jiro Watari, and Hiroto Miwa
Journal of Neurogastroenterology and Motility 2016; 22(4): 677-685  https://doi.org/10.5056/jnm15187
Dai-Kenchu-To, a Herbal Medicine, Attenuates Colorectal Distention-induced Visceromotor Responses in Rats
Kumi Nakaya, Yohko Nagura, Ryoko Hasegawa, Hitomi Ito, and Shin Fukudo
Journal of Neurogastroenterology and Motility 2016; 22(4): 686-693  https://doi.org/10.5056/jnm15190
Repeated Water Avoidance Stress Alters Mucosal Mast Cell Counts, Interleukin-1β Levels with Sex Differences in the Distal Colon of Wistar Rats
Ju Yup Lee, Nayoung Kim, Yong Sung Kim, Ryoung Hee Nam, Min Hee Ham, Hye Seung Lee, Wonjun Jo, Youngkwang Shim, Yoon Jin Choi, Hyuk Yoon, Cheol Min Shin, and Dong Ho Lee
Journal of Neurogastroenterology and Motility 2016; 22(4): 694-704  https://doi.org/10.5056/jnm16007
Image and Learning
Raft Formation of Sodium Alginate in the Stomach
Hee Man Kim
Journal of Neurogastroenterology and Motility 2016; 22(4): 705-706  https://doi.org/10.5056/jnm16068
Letter to the Editor
Nav1.7 and Nav1.8: Diabetes-induced Changes in Primary Sensory Neurons in Rats
Jianlin Lv, Mingjie Wang, and Meng Xia
Journal of Neurogastroenterology and Motility 2016; 22(4): 707-708  https://doi.org/10.5056/jnm16110
Reduced Calorie Sweetener Use Does Not Adversely Affect Gastrointestinal Health and Function
Sylvia P Poulos
Journal of Neurogastroenterology and Motility 2016; 22(4): 709-709  https://doi.org/10.5056/jnm16112
Pathophysiological Studies Are Mandatory to Understand the Benefit of Proton Pump Inhibitors in Patients with Idiopathic Pulmonary Fibrosis
Edoardo Savarino, Patrizia Zentilin, Elisa Marabotto, and Vincenzo Savarino
Journal of Neurogastroenterology and Motility 2016; 22(4): 710-711  https://doi.org/10.5056/jnm16120

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October 2016
Volume 22
Issue 4
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The aim of the Journal is to foster and promote research activities on the area of the motor, sensory and functional disorders of gastrointestinal tract. The Journal provides researchers with accessible rooms for publication of their research results in the field of neuroga- stroenterology and motility. more
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