• Improving High-resolution Impedance Manometry Using Novel Viscous and Super-viscous Substrates in the Supine and Upright Positions: A Pilot Study

    Examples of high-resolution impedance manometry studies using novel viscous and super-viscous solutions. Impedance and high-resolution manometry plots are shown in the top and bottom panels, respectively. (A) 5-g “Thick-It” solution. (B) 7-g “Thick-It” solution. (C) 10-g “Thick-It” solution.

  • Quantitative Analysis of Distribution of the Gastrointestinal Tract Eosinophils in Childhood Functional Abdominal Pain Disorders

    Photomicrograph of hematoxylin and eosin staining for eosinophils in the ascending colon. Infiltration of tissue eosinophils increased in a definite order of specimen of normal controls (A), functional abdominal pain disorders(B), Crohn’s disease (C), and ulcerative colitis (D) (magnification, ×400).

  • Expression of Toll-like Receptors, Pro-, and Anti-inflammatory Cytokines in Relation to Gut Microbiota in Irritable Bowel Syndrome: The Evidence for Its Micro-organic Basis

    Immunohistochemical analysis of Toll-like receptors (TLRs) 4 and 5 among different subtypes of patients with irritable bowel syndrome (IBS) and controls. Figures (A) and (B) show protein expression of TLR-4 and TLR-5 in colonic biopsies among different subtypes of IBS patients and controls. Protein expression of TLR-4 (C) and TLR-5 (D) was quantified using ImageJ software plugins. Figures (C) and (D) show the percentage contribution of positive cells for TLR-4 and TLR-5. IBS-C, constipation-predominant IBS; IBS-D, diarrhea-predominant IBS.

  • Role of High-affinity Choline Transporter 1 in Colonic Hypermotility in a Rat Model of Irritable Bowel Syndrome

    Immunostaining of high-affinity choline transporter 1 (CHT1) in the colon. (A) Double-immunostaining for CHT1 and transmembrane
    member 16A (TMEM16A) in longitudinal colonic sections from control and water avoidance stress (WAS) rats (×400) revealing that CHT1 in the circular muscle of both naive and WAS rats is exclusively expressed in TMEM16A-immunoreactive (IR) cells and the number of CHT1-IR cells in the muscular layer of WAS rats is significantly increased compared to that of control rats. (B) Double-immunofluorescence on whole-mount preparations of colonic myenteric plexus (MP) (×400) illustrating that TMEM16A is robustly expressed in colonic MP and that all the CHT1-IR cells are co-labelled with TMEM16A. The percentage of CHT1-IR cells in the MP is substantially elevated after 10 days of WAS. Different layers were marked out. White arrows indicate CHT1-positive cells that are mainly fusiform in shape and found within circular muscle, exhibiting the morphological characteristics of interstitial cells of Cajal. White arrowheads indicate CHT1-positive cells that are predominantly round in shape and located between circular and longitudinal muscles, showing the hallmark of MP neurons. ML, mucosal layer; SML, submucosal layer; CML, circular muscle layer; LML, longitudinal muscle layer.


J Neurogastroenterol Motil 2018; 24(4): 507~680 Total PDF
Editorials
It Is Time to Meet the Challenges of the Changing Epidemiology of Gastroesophageal Reflux Disease
Gwang Ha Kim
J Neurogastroenterol Motil 2018; 24(4): 507-509  https://doi.org/10.5056/jnm18152
Do Toll-like Receptors Play a New Role as a Biomarker of Irritable Bowel Syndrome?
Hyun Jin Kim
J Neurogastroenterol Motil 2018; 24(4): 510-511  https://doi.org/10.5056/jnm18153
Reviews
Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders
Michiko Kano, Patrick Dupont, Qasim Aziz, and Shin Fukudo
J Neurogastroenterol Motil 2018; 24(4): 512-527  https://doi.org/10.5056/jnm18072
Meta-Analysis
Aloe vera Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis
Seung Wook Hong, Jaeyoung Chun, Sunmin Park, Hyun Jung Lee, Jong Pil Im, and Joo Sung Kim
J Neurogastroenterol Motil 2018; 24(4): 528-535  https://doi.org/10.5056/jnm18077
Reviews
Cultural Factors Influencing Functional Gastrointestinal Disorders in the East
Kee-Huat Chuah and Sanjiv Mahadeva
J Neurogastroenterol Motil 2018; 24(4): 536-543  https://doi.org/10.5056/jnm18064
Sex-Gender Differences in Irritable Bowel Syndrome
Young Sun Kim and Nayoung Kim
J Neurogastroenterol Motil 2018; 24(4): 544-558  https://doi.org/10.5056/jnm18082
Original Articles
The Changing Epidemiology of Gastroesophageal Reflux Disease: Are Patients Getting Younger?
Takahisa Yamasaki, Colin Hemond, Mohamed Eisa, Stephen Ganocy, and Ronnie Fass
J Neurogastroenterol Motil 2018; 24(4): 559-569  https://doi.org/10.5056/jnm18140
Improving High-resolution Impedance Manometry Using Novel Viscous and Super-viscous Substrates in the Supine and Upright Positions: A Pilot Study
Uni Wong, Erik B Person, Donald O Castell, Erik von Rosenvinge, Jean-Pierre Raufman, and Guofeng Xie
J Neurogastroenterol Motil 2018; 24(4): 570-576  https://doi.org/10.5056/jnm18010
Pathophysiology of Potassium-competitive Acid Blocker–refractory Gastroesophageal Reflux and the Potential of Potassium-competitive Acid Blocker Test
Tatsuhiro Masaoka, Hisako Kameyama, Tsuyoshi Yamane, Yuta Yamamoto, Hiroya Takeuchi, Hidekazu Suzuki, Yuko Kitagawa, and Takanori Kanai
J Neurogastroenterol Motil 2018; 24(4): 577-583  https://doi.org/10.5056/jnm18036
Development and Psychometric Assessment of a Self-evaluation Questionnaire for Gastroesophageal Reflux Disease
Hye-kyung Jung, Myung-Gyu Choi, Myung-Ki Baek, and Justin C Y Wu
J Neurogastroenterol Motil 2018; 24(4): 584-592  https://doi.org/10.5056/jnm18085
Association Between Anxiety and Depression and Gastroesophageal Reflux Disease: Results From a Large Cross-sectional Study
Ji Min Choi, Jong In Yang, Seung Joo Kang, Yoo Min Han, Jooyoung Lee, Changhyun Lee, Su Jin Chung, Dae Hyun Yoon, Boram Park, and Yong Sung Kim
J Neurogastroenterol Motil 2018; 24(4): 593-602  https://doi.org/10.5056/jnm18069
Prevalence and Risk Factors of Functional Dyspepsia in Health Check-up Population: A Nationwide Multicenter Prospective Study
Sung Eun Kim, Nayoung Kim, Ju Yup Lee, Kyung Sik Park, Jeong Eun Shin, Kwangwoo Nam, Hyeon Ju Kim, Hyun Joo Song, Young-Eun Joo, Dae-Seong Myung, Ji-Hyun Seo, Hyun Jin Jo, Seon Mie Kim, Seon Hee Lim, Hyun Jin Kim, Gwang Ho Baik, Sang Hyeon Choi, and Suck Chei Choi
J Neurogastroenterol Motil 2018; 24(4): 603-613  https://doi.org/10.5056/jnm18068
Quantitative Analysis of Distribution of the Gastrointestinal Tract Eosinophils in Childhood Functional Abdominal Pain Disorders
Eun Hye Lee, Hye Ran Yang, and Hye Seung Lee
J Neurogastroenterol Motil 2018; 24(4): 614-627  https://doi.org/10.5056/jnm18050
Expression of Toll-like Receptors, Pro-, and Anti-inflammatory Cytokines in Relation to Gut Microbiota in Irritable Bowel Syndrome: The Evidence for Its Micro-organic Basis
Ratnakar Shukla, Ujjala Ghoshal, Prabhat Ranjan, and Uday C Ghoshal
J Neurogastroenterol Motil 2018; 24(4): 628-642  https://doi.org/10.5056/jnm18130
Role of High-affinity Choline Transporter 1 in Colonic Hypermotility in a Rat Model of Irritable Bowel Syndrome
Meng-juan Lin and Bao-ping Yu
J Neurogastroenterol Motil 2018; 24(4): 643-655  https://doi.org/10.5056/jnm18040
MicroRNA-200a Targets Cannabinoid Receptor 1 and Serotonin Transporter to Increase Visceral Hyperalgesia in Diarrhea-predominant Irritable Bowel Syndrome Rats
Qiuke Hou, Yongquan Huang, Changrong Zhang, Shuilian Zhu, Peiwu Li, Xinlin Chen, Zhengkun Hou, and Fengbin Liu
J Neurogastroenterol Motil 2018; 24(4): 656-668  https://doi.org/10.5056/jnm18037
The Effect of Trimebutine on the Overlap Syndrome Model of Guinea Pigs
Zahid Hussain, Da Hyun Jung, Young Ju Lee, and Hyojin Park
J Neurogastroenterol Motil 2018; 24(4): 669-675  https://doi.org/10.5056/jnm18049
Letter to the Editor
To Understand the Modulatory Effect of Probiotics on Irritable Bowel Syndrome
Anlong Yuan, Peng Li, Li Wang, Bibo Zhong, Bin Bai, Xiaoyu Huang, and Jiguang Kou
J Neurogastroenterol Motil 2018; 24(4): 676-677  https://doi.org/10.5056/jnm18097
Overexpression of Stromal Interaction Molecule 1/Store-operated Calcium Entry-associated Regulatory Factor in Interstitial Cells of Cajal in Mouse Jejunum Impairs Pacemaker Activity
Jian-Lin LV, Ning-Yuan Chen, and Shang-Ling Pan
J Neurogastroenterol Motil 2018; 24(4): 678-680  https://doi.org/10.5056/jnm18066

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Current Issue

October 2018
Volume 24
Issue 4
  • News & Notice
  • Tae Hee Lee
    Institute for Digestive Research, Soonchunhyang University Seoul Hospital, Seoul, Korea
    Jung Ho Park
    Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea
  • Lin Lin
    Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
    Meiyun Ke
    Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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The aim of the Journal is to foster and promote research activities on the area of the motor, sensory and functional disorders of gastrointestinal tract. The Journal provides researchers with accessible rooms for publication of their research results in the field of neuroga- stroenterology and motility. more

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