Functional constipation (FC) is a common symptom- based gastrointestinal (GI) disorder without organic abnormality, the prevalence of which is between 5% and 20% of the general population.1,2 The symptoms of constipation can be severe; thus, this disorder has a significant impact on patient's quality of life.3 The cause of FC remains unclear, especially for slow transit constipation. Alterations of the gut microbiota have been suggested as one possible pathophysiologic mechanism of FC.4,5 However, the quantitative and/or qualitative changes of the gut microbiota in FC are poorly understood, and many discrepancies exist in the literature.
In the current issue of the
Kim et al6 investigated the efficacy of VSL#3 probiotics on fecal microbiota and symptom improvement in patients with FC. Mean Bristol stool scores and the numbers of complete spontaneous bowel movements (CSBMs)/week increased significantly in patients with FC treated with VSL#3. Relief of subjective symptoms including CSBM frequency, stool consistency, and abdominal bloating was reported in up to 70% of patients.
Gut microbiota are clearly associated with GI motility.12 In germ free rat model, intestinal bacteria promoted or suppressed the initiation and migration of the migrating myoelectric complex depending on the species.13 Gut microbiota can affect intestinal motor functions either directly or indirectly via mediators released by the gut immune response, the end-products of bacterial fermentation, or intestinal neuroendocrine factors.12,14?16
Some probiotic bacteria have been shown to stimulate intestinal motility in both animal and human studies. For instance,
Probiotics may accelerate intestinal transit by decreasing the proliferation of methanogens in patients with FC. Intestinal methanogens can slow intestinal transit via methane production,22 since overproduction of methane has been shown to directly inhibit motor activity.23 Consistent with these findings, the prevalence of methane-producing bacteria has been shown to be higher in patients with slow transit compared with healthy controls.4,24 Probiotics may also increase intestinal fermentation and there by enhance colonic peristalsis, which decreases transit time in FC. For instance, colonic fermentation of a physiologically relevant malabsorbed quantity of starch has been shown to significantly increase the number of high amplitude propagated contractions (HAPCs).25 Short chain fatty acids (SCFAs), a major end-product of bacterial fermentation, have been shown to increase parietal tone and stimulate ileal propulsive contractions when administered into the human terminal ileum.26,27 SCFAs have been proposed to stimulate motor responses by releasing neuroendocrine factors and/or lowering the intracolonic pH.27,28 Animal studies have demonstrated that SCFAs can initiate HAPCs and accelerate intestinal transit and motility via the intestinal release of 5-hydroxytryptamine.29 However, a recent human study found no significant differences compared with basal values regarding either the global motility index or the number of HAPCs after intracolonic infusion of acidic solutions or SCFAs. This finding indicates that the increased colonic motor activity induced by bacterial fermentation is not caused by acidification of the colonic contents or the production of SCFAs.30 Bacterial fermentation may influence intestinal motility through other mechanisms such as the production of gases, since colonic distension is associated with increased HAPCs,31 and/or other fermentation byproducts such as alcohols, ketones and aldehydes.
As aforementioned, intestinal transit can be accelerated by probiotics, however, some other probiotics have been shown to decrease bowel movements, and improve loose stool/diarrhea in patient with diarrhea predominant-irritable bowel syndrome.32,33 Thus, probiotics may have functions to normalize intestinal motility. Further studies are needed to evaluate the precise effects of gut microbiota and probiotics on GI motility, including the exact effects of fermentation in this process.
A few clinical trials have demonstrated beneficial effects of probiotics in patients with FC. In a recent meta-analysis, 2 RCTs demonstrated that probiotics enhanced the response to therapy in patients with FC.34?36 However, this result was not statistically significant (relative risk of failure to respond to therapy = 0.29; 95% CI, 0.07?1.12) and the data were quite heterogeneous. Two trials reported a significant increase in the mean number of bowel movements per week in total of 165 patients (1.49; 95% CI, 1.02?1.96).34,36,37 Another meta-analysis of 14 RCTs (1,182 patients) reported that probiotics significantly reduced whole gut transit time by 12.4 hours, increased stool frequency by 1.3 bowel movements per week, and also improved stool consistency.38 However, these results also should be interpreted cautiously due to the high study heterogeneity and risk of bias. The efficacy of probiotics for treating FC has not yet been determined, and more RCTs are needed to evaluate the precise relationship between probiotics and FC.
Finally, Kim et al6 performed an elegant study of the compositional changes of the gut microbiota in FC, a process about which little is known, and demonstrated the effect of short-term treatment with VSL#3 on FC using objective parameters such as CSBM and stool consistency, although this study did not show a generalized view of the diverse fecal microbiota and was not a placebo-controlled trial. These findings are cautiously promising with respect to the use of specific probiotic species in the management of FC. Additional well designed clinical studies are needed to determine the true efficacy of probiotics and to elucidate their mechanisms of action, which may include byproducts of bacterial metabolism such as gas and SCFA, in FC.