J Neurogastroenterol Motil 2018; 24(4): 603-613  https://doi.org/10.5056/jnm18068
Prevalence and Risk Factors of Functional Dyspepsia in Health Check-up Population: A Nationwide Multicenter Prospective Study
Sung Eun Kim,1,2 Nayoung Kim,2,3* Ju Yup Lee,4 Kyung Sik Park,4 Jeong Eun Shin,5 Kwangwoo Nam,5 Hyeon Ju Kim,6 Hyun Joo Song,7 Young-Eun Joo,8 Dae-Seong Myung,8 Ji-Hyun Seo,2 Hyun Jin Jo,2 Seon Mie Kim,2 Seon Hee Lim,9 Hyun Jin Kim,10 Gwang Ho Baik,11 Sang Hyeon Choi,11 and Suck Chei Choi12
1Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea; 2Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea; 3Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; 4Department of Internal Medicine, Keimyung University College of Medicine, Daegu, Korea; 5Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Chungcheongnam-do, Korea; Departments of 6Family Medicine and 7Internal Medicine, Jeju National University School of Medicine, Jeju, Korea; 8Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea; 9Departments of Internal Medicine, Healthcare system Gangnam Center Seoul National University Hospital, and Healthcare Research Institute, Seoul, Korea; 10Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Gyeongsangnam-do, Korea; 11Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Gangwon-do, Korea; and 12Department of Internal Medicine, Wonkwang University College of Medicine, Iksan, Jeollabuk-do, Korea
Correspondence to: Nayoung Kim, MD, PhD
Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, Gyeonggi-do 13620, Korea
Tel: +82-31-787-7008, Fax: +82-31-787-4051, E-mail: nayoungkim49@empas.com
Received: April 6, 2018; Revised: May 17, 2018; Accepted: June 10, 2018; Published online: October 1, 2018.
© The Korean Society of Neurogastroenterology and Motility. All rights reserved.

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Abstract
Background/Aims
Functional dyspepsia (FD) is one of the most common gastrointestinal disorders, and FD imposes social and economic burden worldwide. The aim of this study is to identify the prevalence and risk factors of FD in health check-up population in tertiary centers in Korea.
Methods
A nationwide multicenter prospective study was performed at 9 tertiary healthcare centers in Korea between September 2016 and June 2017. A total of 2525 subjects were investigated based on endoscopic findings and questionnaires with the Rome III criteria, and Helicobacter pylori serology (IgG).
Results
A total of 1714 subjects without organic disease were enrolled. The mean (± SD) age was 51.5 (± 12.7) years, and 917 patients (53.5%) were female. The proportion of H. pylori seropositivity was 51.0% (874/1714). The prevalence of FD was 10.3% (176/1714), and the subtypes of postprandial distress syndrome alone, epigastric pain syndrome alone, and postprandial distress syndrome-epigastric pain syndrome overlap were 4.8%, 3.0%, and 2.5%, respectively. Multivariate analysis showed that female gender (OR, 1.58; 95% CI, 1.14-2.21) and education below college level (OR, 1.45; 95% CI, 1.01-2.07) were related to FD. Multivariate analysis based on age 60 showed female gender as a significant (OR, 2.90; 95% CI, 1.06-7.94) factor in the group ≥ 60 years.
Conclusions
The prevalence of FD was 10.3% in the health check-up population in Korea. Female sex and education below college level were risk factors for FD. Female sex is a risk factor for FD in old age, underscoring the need for close attention in this age group.
Keywords: Dyspepsia; Female; Gastrointestinal disorders; Risk factors


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