J Neurogastroenterol Motil 2018; 24(4): 584-592  https://doi.org/10.5056/jnm18085
Development and Psychometric Assessment of a Self-evaluation Questionnaire for Gastroesophageal Reflux Disease
Hye-kyung Jung,1 Myung-Gyu Choi,2* Myung-Ki Baek,3 and Justin C Y Wu4
1Department of Internal Medicine, Ewha Womans University, College of Medicine, Seoul, Korea; 2Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea; 3Department of Internal Medicine, College of Medicine, International St. Mary's Hospital, Catholic Kwandong University, Incheon, Korea; and 4Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong
Correspondence to: Myung-Gyu Choi, MD, PhD
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 222 Banpodae-ro, Seocho-gu, Seoul 06591, Korea
Tel: +82-2-2258-6023, Fax: +82-2-2258-2055, E-mail: choim@catholic.ac.kr
Received: May 14, 2018; Revised: July 11, 2018; Accepted: July 31, 2018; Published online: October 1, 2018.
© The Korean Society of Neurogastroenterology and Motility. All rights reserved.

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Abstract
Background/Aims
There is uncertainty about how to measure outcomes reported by patients in gastroesophageal reflux disease (GERD). This study was conducted to develop an instrument and to determine of the definition of respondent for a patient reported outcomes to assess the efficacy of a treatment used for GERD treatment.
Methods
A structural process has developed a self-evaluation questionnaire for GERD (SEQ-GERD); health-related quality of life questionnaire for GERD (GERD-QOL) was translated through cross-cultural validation. Two-week reproducibility was evaluated and construct validity was assessed by correlating the SEQ-GERD with the Patient Assessment of Gastrointestinal Disorders (PAGI-SYM), the reflux disease questionnaire (RDQ), and GERD-QOL. Changes in SEQ-GERD scores were compared to assess the discriminative validity following 4 weeks of proton pump inhibitor administration.
Results
A total of 83 Korean patients were included (mean age 46 ± 14 years, females 61.4%). The internal consistency of the 19-item SEQ-GERD was good (alpha = 0.60-0.94) and the test–retest reliability was high (intra-class correlation coefficient = 0.67-0.95). The SEQ-GERD highly correlated with the GERD domain of the PAGI-SYM (correlation coefficient r = 0.894, P < 0.001), the RDQ-GERD (r = 0.877, P < 0.001), and GERD-QOL (r = –0.536, P < 0.05). SEQ-GERD scores significantly varied according to the overall treatment effectiveness scale of drug responsiveness and significantly decreased after drug treatment (mean differences according to the overall treatment effectiveness scale, P = 0.020).
Conclusion
This study supports that SEQ-GERD is reliable and valid, and can be used to evaluate the treatment response in patients with GERD.
Keywords: Gastroesophageal reflux disease; Patient reported outcome measures; Surveys and questionnaires; Validation studies


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