Journal of Neurogastroenterology and Motility 2018; 24(3): 331-333  https://doi.org/10.5056/jnm18105
Is High-resolution Anorectal Pressure Topography More Useful Than Wave Manometry in Dyssynergic Defecation?
Tae Hee Lee
Institute for Digestive Research, Soonchunhyang University Seoul Hospital, Seoul, Korea
Correspondence to: *Tae Hee Lee, MD, PhD, Institute for Digestive Research, Digestive Disease Center, Soonchunhyang University College of Medicine, 59, Daesagwan-ro, Hannam-dong, Yongsan-gu, Seoul 04401, Korea, Tel: +82-2-710-3084, Fax: +82-2-709-9696, E-mail: iman0825@schmc.ac.kr
Received: June 8, 2018; Accepted: June 10, 2018; Published online: July 1, 2018.
© The Korean Society of Neurogastroenterology and Motility. All rights reserved.

cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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A subset of chronic constipated patients has functional defecatory disorders, which are characterized by outlet dysfunction.1 This outlet dysfunction includes paradoxical contraction or inadequate relaxation of the pelvic floor muscles during attempted defecation (ie, dyssynergic defecation [DD]) and/or inadequate propulsive forces (ie, inadequately defecatory propulsion). Excessive straining, feeling of incomplete evacuation, digital impaction or anal pain are frequently seen in patients with DD. However, these symptoms are poor predictors of DD.2,3 Normal defecation is achieved by appropriate rectoanal coordination, which means adequate expulsion pressure in the rectum together with relaxation of the puborectalis and the external anal sphincter.4 The defecation process can be demonstrated by anorectal manometry (ARM), rectal balloon expulsion test (BET), anal surface electromyography, or imaging studies.

ARM and rectal BET are widely used for diagnosing defecatory disorders in constipated patients.5 Recently high-resolution anorectal manometry (HR-ARM) is increasingly used in clinical practice. HR-ARM provides a continuous and dynamic spatiotemporal mapping of anorectal pressures, allowing easier and more detailed data interpretation.6 A pull-through technique is not required during HR-ARM examination. In addition, topographic presentation of pressure data facilitates rapid positioning of the catheter. Therefore, the duration of the examination is shorter with HR-ARM then with conventional ARM.7,8 Kang et al8 reported that HR-ARM clarified the pelvic floor dyssynergia in some constipated patients in whom conventional ARM showed an equivocal finding due to its better spatiotemporal resolution. HR-ARM patterns that suggest obstructed defecation of a large rectocele may be useful for selecting patients who require defecography.9 Indeed, the HR-ARM pressure profile during simulated evacuation identified rectal prolapse with an accuracy of 96% and also identified 2 unique phenotypes in patients with rectal prolapse, which were characterized by high (PC1) or low (PC2) anal pressures at rest and squeeze along with higher rectal and anal pressures (PC1) or a higher recto-anal gradient during evacuation (PC2).9

Currently, there is a lack of information regarding whether HR-ARM is more useful to identify DD compared to conventional ARM. Several questions also exist about the use of HR-ARM to diagnose DD: (1) The utility of a negative rectoanal pressure gradient as a marker of DD is unclear because of the considerable overlap in this gradient among healthy individuals and constipated patients.10 (2) Rao’s pelvic floor dyssynergia classification based on the rectal and anal pressure during bearing down is limited to discriminate healthy from constipated patients with/without DD, although 2 subtypes (ie, II and IV) were significantly more frequent in DD.11 (3) Bharucha’s 3 phenotypes derived from principal component analyses had modest diagnostic performance with 75% sensitivity and 75% specificity in discriminating healthy adults from constipated patients with abnormal BET.12 Moreover, weak agreement in diagnosis in normal pattern, type II and type III dyssynergic pattern based on line plots of HR-ARM.11 The manometric parameters during simulated evacuation depend on the type of recording catheter, the distension of the intrarectal balloon, the body position as well as the nature of voluntary participation.13 Given the physiological mechanism of normal defecation, bearing down on-commode with an inflated rectal balloon might improve the diagnostic performance for DD during HR-ARM examination.

In this issue of Journal of Neurogastroenterology and Motility, Lee et al14 reported that high-resolution anorectal pressure topography (HRPT) may identify more structural and functional abnormalities, especially on-commode with an inflated rectal balloon. They evaluated 93 constipated patients for identifying DD using HRPT and waveform manometry (WM) during attempted defecation “on-bed: without inflated rectal balloon and “on-commode” with a 60-mL inflated rectal balloon. Eleven healthy volunteers were also assessed. Their aims were 3-fold: (1) to compare manometric assessment of DD and its subtypes using both HRPT and WM, (2) to determine the correlation between techniques, and (3) to find other additional advantages of HRPT over WM. The agreement of DD types between the 2 techniques was weak. There was also a weak correlation in the length of anal sphincters and rectal and anal pressure during bearing down on commode between the contour and line plots. HRPT allowed the identification of the proximal and distal anal pressure segments during attempted defecation, which was not discernible with WM. In constipated vs healthy participants, the proximal segment was more expanded (2.0 cm vs 1.0 cm, P = 0.003) and of greater pressure (94.8 mmHg vs 54.0 mmHg, P = 0.010) during bearing down on-commode but not on-bed.14 These exaggerated lengthening and increase in pressure of the proximal anal segment is likely to be a result of recruitment and anterior pull of the puborectalis muscle acting on the cranial part of the anal canal. This lengthening may pose resistance to the outlet and then functional obstruction to the stool flow (Figure). The findings of these authors are consistent with that of another 3-dimensional HR-ARM study.15 In the 3-dimensional HRPT study, 79 constipated patients with paradoxical puborectalis syndrome (PPS) and 71 healthy controls were evaluated. Resting pressure, high pressure zone length, and residual anal pressure were found to be significantly higher in patients with PPS compared with healthy adults. Patients with PPS had typically purple high-pressure area in the posterior wall of the pressure cylinder during stimulated defecation that was absent in healthy adults.15

The authors acknowledged several limitations of their analyses, including (1) a lack of healthy controls matched for age and sex, (2) potential presence of anal sphincter injury in multiparous women and (3) a lack of validation of the expanded proximal anal segment using imaging study (eg, endoanal ultrasound).14 Despite of these limitations, the results from Lee et al14 serve as an important foundation for future prospective investigations: (1) to assess whether on-commode during bearing down is additionally included in the standardized protocol of HR-ARM, (2) to assess how the changes in metrics between with/without inflated balloon are clinically relevant, and (3) to validate the lengthening of proximal anal segment using imaging studies and then to evaluate whether this exaggerated expansion is a surrogate for DD.

Acknowledgements

This work was supported by the Soonc-hunhyang University Research Fund.

Figures
Fig. 1. High-resolution anorectal manometry (upper panel) and barium defecography (lower panel) in 3 constipated patients with different combinations of the proximal anal segment length during simulated evacuation. (A) Type I pelvic floor dyssynergia with the proximal anal segment of length 0.9 cm. (B) Type I pelvic floor dyssynergia with proximal anal segment measuring 0.3 cm. (C) Type II pelvic floor dyssynergia with absent proximal anal segment. (D) Rectal emptying disorder with prominent resistance to rectal outlet (black arrow) in one patient with high-resolution pressure topography (A). (E) Rectal emptying disorder with the puborectalis indentation (black arrow) in another patient with high-resolution pressure topography (B). (F) 3 cm sized rectocele (black solid arrow) and descending perineum syndrome with intact emptying (stars indicate anorectal junction at rest and evacuation, respectively) in the other patient with high-resolution pressure topography (C).

Footnotes

Financial support: None.

Conflicts of Interest: None.

References
  1. Rao, SS, Bharucha, AE, and Chiarioni, G (2016). Functional anorectal disorders. Gastroenterology. 150, Array-1442.
    CrossRef
  2. Glia, A, Lindberg, G, Nilsson, LH, Mihocsa, L, and Akerlund, JE (1999). Clinical value of symptom assessment in patients with constipation. Dis Colon Rectum. 42, 1401-1408.
    Pubmed CrossRef
  3. Koch, A, Voderholzer, WA, Klauser, AG, and Müller-Lissner, S (1997). Symptoms in chronic constipation. Dis Colon Rectum. 40, 902-906.
    Pubmed CrossRef
  4. Bharucha, AE (2006). Pelvic floor: anatomy and function. Neurogastroenterol Motil. 18, 507-519.
    Pubmed CrossRef
  5. Bharucha, AE, and Rao, SS (2014). An update on anorectal disorders for gastroenterologists. Gastroenterology. 146, Array-45.
    KoreaMed CrossRef
  6. Lee, TH, and Bharucha, AE (2016). How to perform and interpret a high-resolution anorectal manometry test. J Neurogastroenterol Motil. 22, 46-59.
    Pubmed KoreaMed CrossRef
  7. Sauter, M, Heinrich, H, and Fox, M (2014). Toward more accurate measurements of anorectal motor and sensory function in routine clinical practice: validation of high-resolution anorectal manometry and Rapid Barostat Bag measurements of rectal function. Neurogastroenterol Motil. 26, 685-695.
    Pubmed CrossRef
  8. Kang, HR, Lee, JE, and Lee, JS (2015). Comparison of high-resolution anorectal manometry with water-perfused anorectal manometry. J Neurogastroenterol Motil. 21, 126-132.
    KoreaMed CrossRef
  9. Prichard, DO, Lee, T, Parthasarathy, G, Fletcher, JG, Zinsmeister, AR, and Bharucha, AE (2017). High-resolution anorectal manometry for identifying defecatory disorders and rectal structural abnormalities in women. Clin Gastroenterol Hepatol. 15, 412-420.
    CrossRef
  10. Noelting, J, Ratuapli, SK, Bharucha, AE, Harvey, DM, Ravi, K, and Zinsmeister, AR (2012). Normal values for high-resolution anorectal manometry in healthy women: effects of age and significance of rectoanal gradient. Am J Gastroenterol. 107, 1530-1536.
    Pubmed KoreaMed CrossRef
  11. Grossi, U, Carrington, EV, Bharucha, AE, Horrocks, EJ, Scott, SM, and Knowles, CH (2016). Diagnostic accuracy study of anorectal manometry for diagnosis of dyssynergic defecation. Gut. 65, 447-455.
    CrossRef
  12. Ratuapli, SK, Bharucha, AE, Noelting, J, Harvey, DM, and Zinsmeister, AR (2013). Phenotypic identification and classification of functional defecatory disorders using high-resolution anorectal manometry. Gastroenterology. 144, Array-322.
    KoreaMed CrossRef
  13. Basilisco, G, and Bharucha, AE (). High-resolution anorectal manometry: an expensive hobby or worth every penny?. Neurogastroenterol Motil.
  14. Lee, YY, Erdogan, A, Yu, S, Dewitt, A, and Rao, SSC (2018). Anorectal manometry in defecatory disorders: a comparative analysis of high-resolution pressure topography and waveform manometry. J Neurogastroenterol Motil. 24, 460-468.
    Pubmed CrossRef
  15. Xu, C, Zhao, R, and Conklin, JL (2014). Three-dimensional high-resolution anorectal manometry in the diagnosis of paradoxical puborectalis syndrome compared with healthy adults: a retrospective study in 79 cases. Eur J Gastroenterol Hepatol. 26, 621-629.
    Pubmed


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