J Neurogastroenterol Motil  
How to Perform and Interpret Functional Magnetic Resonance Imaging Studies in Functional Gastrointestinal Disorders
In-Seon Lee,1,2 Hubert Preissl,3-7and Paul Enck1*
1Psychosomatic Medicine and Psychotherapy Department, University of Tübingen, Tübingen, Germany 2IMPRS for Cognitive and Systems Neuroscience, Tübingen, Germany 3Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany 4Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany 5German Center for Diabetes Research (DZD), Tübingen, Germany 6Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, University of Tübingen, Tübingen, Germany 7Interfaculty Center for Pharmacogenomics and Pharma Research, University of Tübingen, Tübingen, Germany
Correspondence to: Paul Enck, PhD
University Hospital, Department of Internal Medicine VI, Osianderstr. 5, 72076 Tübingen,Germany
Tel: +49-07071-29-89118, Fax: +49-07071-29-4382, E-mail: paul.enck@uni-tuebingen.de
Received: November 8, 2016; Accepted: December 19, 2016; Published online: March 2, 2017.
© The Korean Society of Neurogastroenterology and Motility. All rights reserved.

cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Functional neuroimaging studies have revealed the importance of the role of cognitive and psychological factors and the dysregulation of the brain-gut axis in functional gastrointestinal disorder patients. Although only a small number of neuroimaging studies have been conducted in functional gastrointestinal disorder patients, and despite the fact that the neuroimaging technique requires a high level of knowledge, the technique still has a great deal of potential. The application of functional magnetic resonance imaging (fMRI) technique in functional gastrointestinal disorders should provide novel methods of diagnosing and treating patients. In this review, basic knowledge and technical/practical issues of fMRI will be introduced to clinicians.
Keywords: Brain; fMRI; Gastrointestinal diseases; Neuroimaging


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