J Neurogastroenterol Motil  
Associations Between Excessive Daytime Sleepiness and Functional Gastrointestinal Disorders: A Population-based Study in China
Sicheng Wu, Shuqi Chen, Yanfang Zhao, Xiuqiang Ma, Rui Wang, and Jia He*
Department of Health Statistics, Second Military Medical University, Shanghai, China
Received: April 6, 2016; Revised: August 25, 2016; Accepted: September 4, 2016; Published online: October 17, 2016.
© The Korean Society of Neurogastroenterology and Motility. All rights reserved.

cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background/Aims
Several studies have demonstrated that sleep problems are associated with functional gastrointestinal disorders (FGIDs), such as irritable bowel syndrome (IBS), and functional dyspepsia etc, but the relationship between excessive daytime sleepiness (EDS) and FGIDs has not been systematically studied in general population. This study aimed to explore the relationship between EDS and specific types of FGIDs and the effect of the number of FGIDs on EDS.
Methods
A sample of 3600 individuals (aged 18-80 years) was selected from 5 regions in China using a randomized stratified multi-stage sampling method. EDS was measured by the Epworth Sleepiness Scale, while FGIDs and gastroesophageal reflux disease (GERD) were assessed by Rome II diagnostic criteria and Reflux Disease Questionnaire, respectively.
Results
The survey was completed by 2906 individuals (response rate: 80.72%), and 644 individuals (22.16%) had EDS. EDS was significantly associated with ulcer-like dyspepsia (OR, 2.50; 95% CI, 1.08-5.79), diarrhea-predominant IBS (OR, 2.00; 95% CI, 1.09-3.66), alternating IBS (OR, 2.32; 95% CI, 1.30-4.13), functional constipation (OR, 1.68; 95% CI, 1.20-2.35), and GERD (OR, 1.72; 95% CI, 1.08-2.72). Risk of EDS increased along with the increasing numbers of FGIDs: with 1 FGID (OR, 1.72; 95% CI, 1.37-2.15); with 2 FGIDs (OR, 2.43; 95% CI, 1.63-3.62); and with 3 or more FGIDs (OR, 3.26; 95% CI, 1.37-7.78).
Conclusions
FGIDs, such as ulcer-like dyspepsia, diarrhea-predominant IBS, alternating IBS, functional constipation, and GERD, were significantly associated with EDS. Those who suffered from more kinds of FGIDs were more susceptible to EDS.
Keywords: Epidemiology; Excessive somnolence disorders; Functional gastrointestinal disorders


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