J Neurogastroenterol Motil  
Chronic Intestinal Pseudo-Obstruction: Clinical and Manometric Characteristics in the Chilean Population
Edith P?rez de Arce O?ate,1 Glauben Landskron Ramos,1 Sandra Hirsch Birn,2 Carlos Defilippi Caffri,1 and Ana Mar?a Madrid Silva1*
1Laboratory of Functional Digestive Diseases and Motility, Division of Gastroenterology, Clinical Hospital Universidad de Chile, 2Laboratory Aging and ECRAN, Human Nutrition Unit, Institute of Nutrition and Food Technology (INTA), Universidad de Chile, Santiago, Chile.
Correspondence to: Ana Mar?a Madrid Silva,
Santos Dumont 999, Independencia, Santiago 8380456, Chile
Tel: +56229788350, E-mail: anamariamadrid@gmail.com/amadrid@hcuch.cl
Received: June 24, 2016; Revised: August 13, 2016; Accepted: August 21, 2016; Published online: September 26, 2016.
© The Korean Society of Neurogastroenterology and Motility. All rights reserved.

cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background/Aims Chronic intestinal pseudo-obstruction (CIPO) is a rare syndrome characterized by a failure of the propulsion of intraluminal content and recurrent symptoms of partial bowel obstruction in the absence of mechanical obstruction. Regional variations of the intestinal compromise have been described. Intestinal manometry can indicate the pathophysiology and prognosis. Our objective is to establish the demographic and clinical characteristics of group Chilean patients and analyze the motility of the small intestine and its prognostic value.
Methods Patients with symptoms of intestinal pseudo-obstruction with dilated bowel loops were included, in all of whom a manometry of the small intestine was performed using perfused catheters.
Results Of the 64 patients included, 51 women (average age 41.5 ± 17.6 years), 54 primary and 10 secondary CIPO were included. Dilatation of the small intestine was the only finding in 38 patients; in the remaining, the compromise was associated with other segments, primarily colon. 49 patients underwent 65 surgeries mainly exploratory laparotomies and colectomies. Intestinal manometry was performed on all patients; 4 “patterns” were observed: neuropathic (n = 26), myopathic (n = 3), mixed (n = 24), and a group without motor activity (n = 11). The most relevant findings were the complex migrating motor disorders and decreased frequency and propagation of contractions. The 9 patients who died had a severe myopathic compromise. Conclusions In our series, isolated small bowel compromise was the most common disorder. Neuropathic motor compromise was observed in most of the patients. Mortality was associated with severe myopathic compromise.
Keywords: Intestinal pseudo-obstruction, Small bowel motility, Small bowel manometry


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