J Neurogastroenterol Motil  https://doi.org/10.5056/jnm19005
Non-pharmacological Approach in the Management of Funcioanl Dyspepsia
Yen-Po Wang1,2,3,4, Charles C Herndon5, and Ching-Liang Lu1,2,3,4*
1Institute of Brain Science, 2Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; 3Endoscopy Center for Diagnosis and Treatment, 4Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; and 5G Oppenheimer Center for Neurobiology of Stress and Resilience (CNSR), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Correspondence to: Ching-Liang Lu, MD
Endoscopy Center for Diagnosis and Treatment, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Rd. Sec. 2, Taipei 111, Taiwan
Tel: +886-2-2875-2111 (ext. 3385), Fax: +886-2-2873-9318, E-mail: cllu@ym.edu.tw/cllu@vghtpe.gov.tw
Received: January 5, 2019; Revised: September 20, 2019; Accepted: October 9, 2019; Published online: November 22, 2019.
© The Korean Society of Neurogastroenterology and Motility. All rights reserved.

Abstract
Functional dyspepsia (FD) is a common functional gastrointestinal disease which bears a significant burden on society and individuals. Despite the high prevalence of FD, its pathophysiology remains poorly understood and the treatment options are limited and unsatisfactory. In the absence of effective pharmacological treatments for FD, non-pharmacological approaches, including: reassurance, lifestyle modification, psychotherapy, dietary interventions, medical food, acupuncture, and electrical stimulation and modulation are sought after by many physicians and FD patients. In this article, we review clinical studies which investigate non-pharmacological therapies for FD. We will also discuss potential mechanisms involved in the therapeutic effects of these non-pharmacological approaches. Though the evidences to support the routine use of the non-pharmacological management is still lacking, the non-invasive nature and potentially minimal side-effects of these therapies may be attractive in the FD management. In order to confirm the clinical effectiveness of these non-pharmacological approaches, more well-conducted, methodologically rigorous, and large-scaled clinical trials are required.
Keywords: Complimentary therapies; Dyspepsia; Electrical stimulation


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