Journal of Neurogastroenterology and Motility 2018; 24(1): 70-78  https://doi.org/10.5056/jnm17019
Interest of Anorectal Manometry During Long-term Follow-up of Patients Operated on for Hirschsprung’s Disease
Viet Q Tran1,2,*, Tania Mahler3, Patrick Bontems3, Dinh Q Truong1, Annie Robert4, Philippe Goyens5, and Henri Steyaert2
1Department of Pediatric Surgery, City Children’s Hospital, Ho Chi Minh City, Vietnam, 2Department of Pediatric Surgery, Hôpital Universitaire des Enfants Reine Fabiola - Université Libre de Bruxelles (ULB), Brussels, Belgium, 3Department of Gastroenterology, Hôpital Universitaire des Enfants Reine Fabiola - Université Libre de Bruxelles (ULB), Brussels, Belgium, 4Faculté de santé publique, Institut de Recherche Expérimentale et Clinique (IREC), Pôle de recherche EPID Epidémiologie et Biostatistique - Université catholique de Louvain (UCL), Brussels, Belgium, 5Laboratory of Pediatrics, Université Libre de Bruxelles (ULB), Brussels, Belgium
Correspondence to: Viet Q Tran, MD, Department of Pediatric Surgery, Hôpital Universitaire des Enfants Reine Fabiola - Université Libre de Bruxelles (ULB), Avenue Jean-Joseph Crocq 15 1020 Brussels, Belgium, Tel: +84-909-490-527, Fax: +84-2-822-538-899, E-mail: dr.tranquocviet@gmail.com
Received: February 15, 2017; Revised: May 25, 2017; Accepted: July 12, 2017; Published online: January 1, 2018.
© The Korean Society of Neurogastroenterology and Motility. All rights reserved.

cc This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

Background/Aims

Although many advances in the management of Hirschsprung’s disease have recently been achieved, postoperative outcomes of these patients remain difficult in a non-negligible number of cases. Therefore, this study aims at investigating characteristics of anorectal manometry and its relationship with postoperative outcomes during long-term follow-up in Hirschsprung patients.

Methods

Patients over 4 years of age operated on for Hirschsprung’s disease were interviewed to complete detailed questionnaires on bowel function. The patients who consented to undergo an anorectal manometry during follow-up were enrolled in this study. We investigated their clinical characteristics, manometric findings, and their postoperative bowel function.

Results

Nineteen patients out of 53 patients (35.8%) were enrolled, 68.4% who were male. Mean age of patients at manometry was 11.3 ± 6.3 years. Twelve out of 19 patients (63.2%) were incontinent. The mean anal resting pressures of incontinent patients were significantly lower than continent patients (47 ± 12 mmHg versus 63 ± 11 mmHg, P < 0.05, t test). Due to neurological impairment, only 11 patients (57.9%) were able to perform a complete manometry. A dyssynergic defecation was found in 4 patients during strain tests. Maximum tolerated volume of the incontinent patients was significantly lower than that of the continent patients (97 ± 67 mL versus 181 ± 74 mL, P < 0.05, t test).

Conclusion

Anorectal manometry is an objective method providing useful information that could guide a more adapted management in patients with defecation disorders after Hirschsprung’s disease operation.

Keywords: Defecation, Follow-up studies, Hirschsprung disease, Manometry, Postoperative period
Introduction

Hirschsprung’s disease (HD) is the most common congenital malformation of the enteric nervous system in children. Although there are many recent advances related to surgical techniques, postoperative outcomes remain variable.1 Defecation disorders may happen after surgery for HD. Fecal incontinence and constipation are the 2 main complaints in the long-term outcome.2

However, a clinically accurate assessment of continence is often difficult to obtain. In the literature, authors report wide ranges of fecal incontinence.37 Continence problems may be due to either a primary motility disorder or sequelae of the surgical techniques.8 To clarify and to understand the importance of these different mechanisms, the pathophysiology of defecation has to be studied. It has been suggested that anorectal manometry could help objectify and distinguish between functional disorders and acquired troubles.913 Otherwise little is known about anorectal manometry in patients after surgery for HD.9,10,14,15 Therefore, this study aims at investigating anorectal manometry findings of patients operated on for HD and the relationship with their outcomes.

Materials and Methods

Study Design

This study was conducted at the Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium and was approved by the research ethics committee of the hospital (CEH 2014-41). All consecutive charts of patients operated on for HD in our department between 1987 and 2010 were retrieved. Demographic and clinical data were retrieved on gender, date of birth, age at surgery, type of operation, enterostomy, operative complications, resected colon segment, and neurological status. Patients over 4 years of age at the time of the study received a letter detailing the planned study and were invited to perform an anorectal manometry as well as to participate in a study on long-term outcome. All manometric findings were collected for analysis in this study.

Fecal continence

Fecal continence was based on the Wingspread classification, which defines the following 4 levels of continence: excellent, very good: clean (totally continent, toilet trained with no medication); good: staining (rarely soiling, except during stressful exercise); fair: intermittent fecal soiling, urge incontinence; poor: constant fecal soiling or smearing.16 Patients classified as “fair” or “poor” were considered as fecally incontinent; the other categories were considered as fecally continent. Fecal continence was considered to have been acquired normally in children older than 4 years.17

Constipation

Patients were interviewed for stooling frequency, use of laxatives and enema over the months preceding investigation. A patient was considered as suffering from constipation if defecation was only possible with laxatives, or occurred less than 3 times per week, according to the Rome III criteria for functional constipation.18

Enterocolitis

History of enterocolitis was reviewed and classified on a scale (none, single time or several times) from medical records as well as at interview for each patient.

Operative procedures

Initially, Soave pull-through with abdominal approach (open Soave) was used in our institution. More recently, transanal endorectal pull-through with or without laparoscopic assistance (minimally invasive surgery Soave) was used. In cases of severe enterocolitis or failure with nursing care (wash-out) before pull-through operation, an enterostomy was performed. For patients with total colon aganglionosis, an ileoanal anastomosis without reservoir was done.

Anorectal manometry

An electrically powered anorectal manometry Medtronic system (serial number: MS4-1867, model number PIP-4–8; Medtronic, Minneapolis, MN, USA) and 14 Fr water perfused catheters with 8 channels were used. An enema (Fleet enema for children with dosage of 3 mL/kg or in some cases with nursing enema by sodium chloride 0.9% solution) was routinely administered prior the test. In addition, a bowel management at least 1 week before the test was taken to facilitate rectal emptying in cases with fecal impaction.

Patients were in the supine position, with the hips and knees flexed. The motility probe and balloon were well lubricated. The patient was asked to lie still, relaxed, and silent as much as possible, and the test started just when an enough familiarization was achieved to insert the probe. Toys, distraction, and relaxation were used to facilitate the examination.

Depending on the ability of cooperation, based mainly on age and neurological status of the patients at investigation, patients were asked to perform consecutive steps of the test, as described below in the section on the profile of anorectal manometry. In this study, patients with chromosomal syndrome (Down’s syndrome and 13q deletion syndrome) were considered as neurologically impaired. A “complete anorectal manometry” was performed when cooperative patients had full capacity to undergo all the steps. Otherwise in non-cooperative patients, only the 2 first steps investigating “anal resting pressure” and “recto-anal inhibitory reflex” were done, therefore considered as an “incomplete anorectal manometry.”

Profile of Anorectal Manometry

Anal resting pressure

At the beginning of the test, a minimum 3-minute familiarization period was undertaken. After this time, the anal resting pressure was recorded. With the patient at rest, anal pressure was measured during 20 seconds; the minimum and maximum values were recorded (mmHg).

Recto-anal inhibitory reflex

The balloon was inflated within 3–5 seconds and subsequently deflated; the initial volume was 10 mL, and was subsequently increased by increments of 10 mL. This test was repeated until a volume of 60 mL was obtained to detect the presence of the recto-anal inhibitory reflex (RAIR) represented by a transient reduction of anal pressure within the inner zone of the anal canal, due to relaxation of the internal anal sphincter after a rapid distention of the rectum by inflation of the balloon.19 In this study a RAIR was reported as positive if the amount of this reduction was over one third of the preceding anal pressure value.

Voluntary maneuvers (when possible)

(1) Coughing maneuver, patients were asked to do 2 single coughs; (2) squeeze maneuver, 2 squeezes of 5 second duration; and (3) endurance squeeze, 2 episodes of squeeze for 20 seconds in duration. The voluntary maneuvers were reported as normal if patients presented with appropriate increases of anal pressure according to their ages in amplitude as well as in duration. An interval time of 20 seconds was routinely required after each maneuver.

Sensation test (when possible)

The balloon was inflated at a rate of 5 mL every 5 seconds and the patient was asked to consequently report: first sensation, desire to defecate, and finally a maximum tolerated volume when intense urge to defecate or an abnormal painful rectal sensation appeared were noted.19

Balloon expulsion test (when possible)

During the final step of the test, the balloon was filled with 10–20 mL of air according to their ages and the patient was then asked to bear down in an attempt to expel the balloon. While the patient tried to evacuate the balloon, we measured the rectal pressure and anal sphincter pressure. Normally, the anal sphincters (internal and external) have to relax at the time of defecation. Failure to evacuate the balloon with paradoxical increase of anal sphincter pressure indicates a dyssynergic defecation.19

Statistical Methods

Data were reported as mean and standard deviation or median and range for continuous variables, according to their distribution, and as number and proportion for categorical variables. The chi-square test or the Fischer exact test was used to compare proportions, and the independent t test was used to compare means. All tests were two-sided and a P-value < 0.05 was considered as significant. IBM SPSS Statistics version 20 (IBM Corp, Armonk, NY, USA) was used for statistical analysis.

Results

Out of 58 consecutive patients operated on for HD in our hospital, 53 (91.4%) accepted to participate in a long-term outcome survey, whereas the 5 remaining patients have been lost to follow-up. All patients had a histopathological confirmation of HD and a normal ganglionic innervation at the level of anastomosis. As the results of the survey regarding 53 patients, prevalence of fecal incontinence was 22.6% (12 patients) and 13.2% (7 patients) for constipation.

Nineteen patients consented to undergo an anorectal manometry and were therefore enrolled in this present study. The demographic and clinical findings of these 19 patients and the 34 others who did not consent to undergo an anorectal manometry are shown in Table 1. There were significant differences between the patients with anorectal manometry and the patients without an anorectal manometry in terms of the age of patients, the operative procedure, and the prevalence of fecal incontinence. No other significant difference was found in terms of neurological status, history of enterostomy, length of resected colon, episodes of enterocolitis, postoperative complication, as well as constipation.

Table 2 shows the characteristics of the 19 patients with anorectal manometry according to their fecal continence status. Mean age of the patients at anorectal manometry was 11.3 ± 6.3 years. Among them, 12 patients (63.2%) presented with fecal incontinence; of note, 3 of those patients reported frequent fecal soiling as well as constipation on the questionnaire. The last 7 patients did not present any defecation problems. Five patients had a chromosomal syndrome (4 with Down’s syndrome and one with 13q deletion syndrome) and were considered as neurologically impaired. The mean age of neurologically impaired patients was significantly younger than the others (7.2 ± 3.2 years versus 13.3 ± 6.3 years, P < 0.05, t test). The neurologically impaired patients had a higher prevalence of fecal incontinence than the patients without neurological impairment; but the difference was not significant (P > 0.05). No other characteristic of patients was significantly associated with fecal incontinence, although there was a tendency of higher association with fecal incontinence in cases with the minimally invasive surgery Soave technique, episodes of enterocolitis, and postoperative complications.

Manometric Findings

Regarding the 19 patients who underwent an anorectal manometry, Table 3 shows the manometric findings of continent patients compared with incontinent patients.

Anal resting pressure of incontinent patients was significantly lower than continent patients (47 ± 12 mmHg versus 63 ± 11 mmHg; P < 0.05, t test). The distribution of patients’ anal resting pressure stratified by their neurologic and fecal continence status is shown in Figure 1.

Eight out of 19 patients (42.1%) showed a relaxation reflex within the internal part of the anal sphincters that was considered as a reappearance of RAIR.

As ability of cooperation depended basically on the age and neurological status of the patients, only 11 out of 19 patients (57.9%) were able to perform a complete anorectal manometry as shown in Table 3. The cough, squeeze, and squeeze duration maneuvers were normal in all of these patients. Patients with fecal incontinence demonstrated a significant decrease of the maximum tolerated volume according to their age (97 ± 67 mL for incontinent patients compared to 181 ± 74 mL for continent patients, P < 0.05). The maximum tolerated volume of these patients during sensation test are shown in detail in Figure 2.

During the strain maneuver, 4 patients showed dyssynergic defecation patterns as illustrated in Figure 3. Two of them clinically presented with significant fecal impaction at investigation and had better outcomes after a bowel management.

Discussion

Surgical treatment of HD consists of resecting the aganglionic bowel segment followed by anastomosis of the normally innervated bowel to the anus. However, it is well established that patients operated on for HD are clinically at high risk of defecation disorders.2,20,21 Indeed, the Soave procedure––a worldwide used technique as well as in our series––was developed specifically to leave a muscular cuff outside of the rectal wall in order to protect the surrounding structures from damage by performing an endorectal dissection. As a consequence, the longer the cuff, the higher incidence of obstructive symptoms sometimes result in overflow incontinence; whereas, the shorter the cuff, the higher incidence of fecal incontinence.22 Clinically, the differentiation between “true” incontinence due to the deficit of anal sphincters or an overflow incontinence resulting from a severe constipation, is therefore essential to obtain a better and more adapted management, but difficult to make.23

Anorectal manometry is considered an objective way to visualize anorectal function. However, there are few reports about anorectal manometry during follow-up of children operated on for HD, and its role still seems controversial in terms of the uses of different anorectal manometry systems (conventional versus high-resolution anorectal manometry [HRAM]), lack of normal value, particularly the reference value of HRAM in HD patients.9,10,14,15 Therefore, this study aimed at investigating the anorectal manometry findings in our patients after operation for HD while considering their long-term bowel function.

Regarding our long-term outcome survey, we report findings similar to those described in the literature, that is, defecation disorders remain problematic issues and challenges in a high percentage of the patients even until adulthood, significantly altering their quality of life, especially in cases with fecal incontinence. This could explain the high percentage of patients suffering from fecal incontinence who consented to our anorectal manometry survey (Table 1). They particularly need close medical attention to manage their fecal incontinence problems.24,25

Anal Resting Pressure

In regard with anal resting pressure, the internal anal sphincter and external anal sphincter contribute to 55.0% and 35.0% of the anal resting pressure, respectively; the remaining 15.0% originating from surrounding perineal anatomical structure.26 Therefore, a reduced anal resting sphincter pressure could be explained by an anal sphincter deficit, especially in HD patients who underwent a pull-through procedure. In the literature, several authors stated that patients with true incontinence present a significantly lower resting pressure than normal subjects.24,27 As also reported by Gad El-Hak et al,25 in a study of 52 patients after pull-through operation, the mean pressure was 58.1 ± 15.1 mmHg among continent cases, 49.1 ± 15.1 mmHg among minor incontinent cases, and 37.1 ± 12.1 mmHg among major incontinent cases with a highly significant difference between continent and major incontinent groups. On the other hand, Meinds et al10 reported a wide range of anal resting pressure 70 (25–110) mmHg. Of note, the HRAM system with solid catheters was used in the study of Meinds et al,10 whereas the conventional polygraph anorectal manometry was used in the study of Gad El-Hak et al.25 In our study, anal resting pressure in incontinent patients was 47 ± 12 mmHg which was significantly lower than in continent patients with 63 ± 11 mmHg (Table 2). Regarding surgical treatment, there is an ongoing debate in the literature on whether the risk of fecal incontinence is associated with the operative technique. Overstretching during endorectal pull-through by retractors can lead to injury of the anal sphincters.21

In our series, the NI patients tended to have a lower anal resting pressure and also demonstrated a high proportion of fecal incontinence, as shown in Figure 1. According to our knowledge there is no report in the literature mentioning a lower anal resting pressure in Hirschsprung patients with trisomy 21 than in normal subjects. Catto-Smith et al28 also reported a very high prevalence of fecal incontinence of 87.0% in children with Down’s syndrome associated with Hirschsprung’s disease. However, Powers et al29 reported as well that bowel continence in patients with Down’s syndrome could appear at a later age than usual, and in our series they were significantly younger than the others. In fact, the management of NI patients is very difficult because of their attention deficit for either clinical or psychosocial aspects.

Rectal Anal Inhibitory Reflex

The reappearance of RAIR in patients operated on for HD is still controversial. Normally this reflex is absent in HD patients and, in the literature, most authors reported no RAIR in anorectal manometry during follow-up of the patients operated on for HD.10 In contrast, Mishalany et al9 and Moore et al11 reported RAIR reappearance in 10.0% and 13.6% of the operated patients for HD, respectively. Recently, Gad El-Hak et al25 reported RAIR becoming intact in 11.5% of the HD patients 4 years after operation as well as their improvement in rectoanal sensation. Interestingly, in our series, 8 out of 19 patients got their RAIR back. In fact RAIR is an intramural local axon reflex controlled by spinal and higher centers.30 So, it raised an hypothesis that the normally innervated bowel anastomosed to the anal canal acquires a “quite normal” rectal function as an adaptation of the neo-rectum years after a pull-through operation.25 However, re-establishment of RAIR was not clinically correlated with any positive long-term outcome in our series as well as in the other studies.9 Of course, a RAIR re-establishment due to technical issues should be always considered.18

Voluntary Anorectal Manometry Maneuvers

Regarding voluntary maneuvers including cough, squeeze, and endurance squeeze as illustrated in Table 2, the 11 full cooperative patients have witnessed an adequate increase of anal tonus in amplitude as well as in duration. These maneuvers are indicated to assess the integrity of spinal reflex pathways of the patients; normally, the increased abdominal pressure triggers voluntarily external sphincter contraction.26 As mentioned above, the complexity of anatomical perineal structures contribute also to the anal tonus. For that reason, voluntary anorectal manometry maneuvers are important for the rationale of biofeedback therapy in patients presenting a severe incontinence due to technically surgical problems.10,31

Sensation Test

Concerning the pathophysiology of fecal incontinence, rectal sensation and rectal compliance are the 2 essential determinants. In our series, the maximum tolerated volume in the incontinent patients was significantly lower than in continent patients (Table 2). As illustrated in Figure 2, there were 3 out of 5 patients with fecal incontinence with a sharp decrease of the maximum tolerated volume. Although we could not measure rectal compliance in these patients, the maximum tolerated volume indirectly provided helpful information about rectal sensation as well as elasticity and reserve capacity of the neo-rectum.26 Therefore, the hypothesis is raised that fecal incontinence could be due to rectal factors where the maximum tolerated volume is often impaired and below normal.32 Here again, technical surgical issues may be of concern. For example, there may be a twisted colon or tension on the inferior mesenteric artery when lowering the colon particularly during a fully transanal endorectal pull-through. This could lead to rectal stenosis and be the reason for postoperative obstructive symptoms accompanied by possible soiling or incontinence.33 For that reason we advocate the use of laparoscopic assistance, instead of open abdominal approach, in order to adequately dissect the colonic mesentery as well as minimize injury during perineal and anorectal dissection and avoiding eventual twist during lowering of the colon.34 To date, this is used routinely in our institution, as well as in many other centers worldwide.35

Dyssynergic Defecation

Even if most postoperative outcomes of HD patients are explained by anatomical issues, some potential functional disorders may partially contribute to these problems as well. Meinds et al10 demonstrated that dyssynergic defecation aggravates the already troublesome defecation in patients after HD operation. In fact, the onset of dyssynergic defecation has been described in postoperative HD patients for a number of reasons. First, a high percentage of fecal soiling as well as an increase in defecation frequency after a pull-through operation could make patients more prone to developing dyssynergic defecation.10 Defecation is painful for most patients after HD surgery, especially in cases with additional treatment such as washouts, anal rectal dilation or sometimes a surgical redo procedure due to complications. They tend to therefore delay defecation for as long as possible. The more apprehensive they are, the more fecal impaction presents and a vicious cycle of pain and delay exists. Hyman36 suggested that these patients tend to avoid bowel movement because of the association with increased anorectal painful sensation. But Rao et al37 suggested that dyssynergic defecation symptoms are also seen in the general population, owing perhaps to their faulty learning of proper defecation during childhood. In these patients, the initial problem could be retentive constipation followed by an overflow incontinence. If not well managed, this process may sometimes result, again, in an irreversibly dilated incompetent colon, whereas this is, in the beginning, a reversible situation using an appropriate bowel management as well as biofeedback therapy.31 In our series, there were 4 patients showing a dyssynergic defecation (Table 2) and 2 of them presented with significant fecal impaction.

Severe fecal incontinence remains the main determinant of decrease in quality of life in patients suffering from HD.2 Therefore, a long-term follow-up by a multidisciplinary team including pediatric surgeons, gastroenterologists, dieticians as well as psychologists is essential. In some instances, if the troubles persist into adolescent or even into adulthood, close cooperation with an adult team specializing in fecal continence is recommended. In our long-term outcomes series, one patient who recently benefited from a sacral nerve stimulation device implantation was operated on by our pediatric surgical team together with an adult team before he was entrusted to the adult team.38,39 We believe this is an important transition for all cases now.

All the above therapeutic strategies should be carefully considered together with the anorectal manometry findings that provide very useful information regarding the actual origin of continence problems not always easy to be clinically distinguished, as reported in this present study. However, this study also had some limitations, for instance a conventional anorectal manometry system was used. Further studies need to be conducted in the future; now we continue with HRAM––a new trend in this field.

Conclusions

Our experiences show that anorectal manometry could be an objective method for investigating anorectal malfunction, providing useful findings in patients presenting with defecation disorders after HD operation. Anorectal manometry may help in decision making on a more objective manner than just clinical examination. Several types of anomalies may be detected leading the medical staff to an individually adapted bowel management or, if necessary, to an appropriate surgical option.

Figures
Fig. 1. Measurements of anal resting pressure (n = 19). Vertical axis represents maximum anal resting pressure; horizontal axis represents minimum anal resting pressure. Note the anal resting pressure lower than 60 mmHg in all 5 neurologically impaired (NI) patients (circle dots) and the tendency to be closer to the bisector (labelled as the x-axis). The closer the dot to the bisector, the smaller the difference between the maximum and the minimum anal resting pressure of the case.
Fig. 2. Maximum tolerated volume measurements related to ages of patients who performed a sensation test (n = 11). The dotted lines represent the normal values: 135 mL in children 6 years of age and 160 mL in children 12 years of age. Adapted from Meinds et al.10
Fig. 3. Anorectal manometry diagram demonstrating inappropriate increases in anal sphincter pressure (black arrows) during strain maneuvers, considered to be dyssynergic defecation. The figure shows the case of an 8-year-old boy, operated on for Hirschsprung’s disease with open Soave. His chief complaint was grade 3 fecal soiling according to the Wingspread classification. The patient underwent a bowel management with laxatives (polyethylene glycol) with good results. Of note, a significant fecal impaction was revealed after consultation suggesting an “overflow incontinence.”
Tables

Patient Characteristics and Defecation Patterns of the 53 Patients With and Without Anorectal Manometry After Surgical Management for Hirschsprung’s Disease at Investigation

Patient characteristics N With AM
n (n/N, %)
Without AM
n (n/N, %)
P-value
Age (mean ± SD, yr) 16.1 ± 7.6 11.3 ± 6.3 18.8 ± 7.0 < 0.001
Age groups (yr) 0.025
 > 4, < 10 12 8 (66.7) 4 (33.3)
 10–16 13 5 (38.5) 8 (61.5)
 > 16 28 6 (21.4) 22 (78.6)
Gender > 0.999
 Male 36 13 (36.1) 23 (63.9)
 Female 17 6 (35.3) 11 (64.7)
Neurological status 0.118
 NI patients 8 5 (62.5) 3 (37.5)
 Non-NI patients 45 14 (31.1) 31 (68.9)
Enterostomy 0.358
 Yes 16 4 (25.0) 12 (75.0)
 No 37 15 (40.5) 22 (59.5)
Resected colon 0.746
 Recto-sigmoid colon 38 15 (39.5) 23 (60.5)
 Descending colon 8 3 (37.5) 5 (62.5)
 Transverse colon 3 0 (0.0) 3 (100.0)
 Total colon 4 1 (25.0) 3 (75.0)
Operative procedure 0.044
 Open Soave 40 11 (27.5) 29 (72.5)
 MIS Soave 13 8 (61.5) 5 (38.5)
Enterocolitis > 0.999
 No 44 16 (36.4) 28 (63.6)
 Single time 5 2 (40.0) 3 (60.0)
 Several times 4 1 (25.0) 3 (75.0)
Postoperative complicationsa
 Anastomotic leak 3 2 1
 Bowel obstruction 3 1 2
 Twisted colon 1 1 0
 Residual aganglionosis 1 0 1
 Total complication 8 4 4 0.436
Fecal incontinence < 0.001
 Yes 12 12 (100.0) 0 (0.0)
 No 41 7 (17.1) 34 (82.9)
Constipation 0.691
 Yes 7 3 (42.9) 4 (57.1)
 No 46 16 (34.8) 30 (65.2)
Total 53 19 (35.8) 34 (64.2)

Postoperative complications reported by number of encountered cases.

AM, anorectal manometry; NI, neurologically impaired; MIS Soave, minimally invasive surgery Soave includes transanal endorectal pull-through with or without laparoscopic assistance.


Patient Characteristics of the 19 Patients Who Consented to Undergo an Anorectal Manometry According to Their Fecal Continence Status at Investigation

Variables N Continence
n (n/N, %)
Incontinence
n (n/N, %)
P-value
Age (mean ± SD, yr) 11.3 ± 6.3 12.7 ± 6.0 10.3 ± 6.6 0.441
Age groups (yr) 0.833
 > 4–10 8 2 (25.0) 6 (75.0)
 10–16 5 2 (40.0) 3 (60.0)
 > 16 6 3 (50.0) 3 (50.0)
Gender > 0.999
 Male 13 5 (38.5) 8 (61.5)
 Female 6 2 (33.3) 4 (66.7)
Neurological status 0.106
 NI patients 5 0 (0.0) 5 (100.0)
 Non-NI patients 14 7 (50.0) 7 (50.0)
Enterostomy 0.603
 Yes 15 5 (33.3) 10 (66.7)
 No 4 2 (50.0) 2 (50.0)
Resected segment 0.702
 Classic recto-sigmoid form 15 5 (33.3) 10 (66.7)
 Long segment formsa 4 2 (50.0) 2 (50.0)
Operative procedure 0.633
 Open Soave 11 5 (45.5) 6 (54.5)
 MIS Soave 8 2 (25.0) 6 (75.0)
Enterocolitis > 0.999
 Yes 3 1 (33.3) 2 (66.7)
 No 16 6 (37.5) 10 (62.5)
Postoperative complication 0.603
 Yes 4 2 (50.0) 2 (50.0)
 No 15 5 (33.3) 10 (66.7)
Constipation 0.263
 Yes 3 0 (0.0) 3 (100.0)
 No 16 7 (43.8) 9 (56.2)
Total 19 7 (36.8) 12 (63.2)

Long segment form includes the cases with descending, transverse, and total colon aganglionosis.

NI, neurologically impaired; MIS Soave, minimally invasive surgery Soave includes transanal endorectal pull-through with or without laparoscopic assistance.


Manometric Findings of the 19 Patients Who Consented to Undergo an Anorectal Manometry According to Their Fecal Continence Status at Investigation

Manometric findings N Continence Incontinence P-value
Anal resting pressure (mean ± SD, mmHg) 63 ± 11 47 ± 12 0.009
Reappearance of RAIR (n [n/N, %]) 0.377
 Yes 8 4 (50.0) 4 (50.0)
 No 11 3 (27.3) 8 (72.7)
Patients with a complete AMa (n) 11 6 5
 Voluntary maneuversb
  Cough maneuver 6 5 -
  Squeeze maneuver 6 5 -
  Endurance squeeze 6 5 -
 Sensation test (mean ± SD, mL)
  First urge 108 ± 79 53 ± 20 0.149
  Maximum tolerated volume 181 ± 74 97 ± 67 0.021
 Dyssynergic defecationc 4 2 2 > 0.999

A complete anorectal manometry (AM) was performed when cooperative patients had full capacity to undergo all the steps.

Data for cough, squeeze, and endurance squeeze presented by numbers of encountered cases with a normal test.

Data reported by number of encountered cases.

RAIR, recto-anal inhibitory reflex.


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