Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 2. c-kit immunohistochemistry. (A) Apex, 13 weeks (tangential cross-section). c-kit immunopositive interstitial cells of Cajal (ICC; arrows) are present at the border of myenteric plexus (MP) ganglia. (B) Base, 16 weeks. c-kit immunopositive ICC (arrows) are present around the MP ganglia and within the outer part of the circular muscle layer (cm). In the submucosa (sm), an oval c-kit-immunoreactive mast cell is seen (arrowhead). (C) Apex, 18 weeks. c-kit immunopositive ICC are present within the entire cm. Most of these cells are spindle-shaped, but some of them contain lateral branches (arrows). The c-kit-immunoreactive mast cell is seen (arrowhead). (D) Apex, 21 weeks (tangential cross-section). Numerous c-kit immunopositive ICC are present within the muscle layers. These are spindle-shaped cells oriented in parallel to the longitudinal axis of the adjacent smooth muscle cells. Around the MP ganglion, there were only individual c-kit immunopositive ICC (arrow). (E) Apex, 24 weeks (tangential cross-section). c-kit immunopositive ICC are extremely numerous within the muscle layers. (F) Base, 33 weeks. c-kit immunopositive ICC are extremely numerous within the muscle layers. Two spindle-shaped c-kit immunoreactive cells (arrows) are present around the ganglion located within the longitudinal muscle layer (lm). ig, intramuscular ganglion. MoAb c-kit. Bar: A = 30 μm, B = 40 μm, C-E = 50 μm, F = 80 μm.
J Neurogastroenterol Motil 2021;27:127~133
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