Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

Download original image
Fig. 9. Transient receptor potential ankyrin 1 (TRPA1)-mediated extracellular signal-regulated protein kinase 1/2 (ERK1/2) activation in nodose neurons after antral cold stimulation in naive rats. (A) Phospho-ERK1/2 (pERK 1/2) labeling in nodose neurons 10 minutes after intra-antral infusion of warm or cold (0°C) saline. Arrows indicate p-ERK1/2-immunoreactive (IR) neurons. **P < 0.01 (Student’s t test). (B) A-967079 (6 μg/mL; intra-antrally administered) suppressed ERK1/2 activation in nodose neurons induced by antral cold stimulation. (C) Double labeling for TRPA1 or transient receptor potential melastatin 8 (TRPM8) and p-ERK1/2 in nodose neurons after infusion of cold saline. Arrows indicate immunoreactive or double-labeled neurons. Scale bar = 100 μm. NG, nodose ganglia.
Journal of Neurogastroenterology and Motility 2019;25:442~460 https://doi.org/10.5056/jnm19014
© J Neurogastroenterol Motil