Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 6. Deletion of transient receptor potential ankyrin 1 (TRPA1) gene abolished cold-induced pronociception in stressed mice. Effect of intra-antral infusion of saline (0.2 mL) at 0°C on visceromotor response (VMR) to colorectal distention (CRD) in wild type (WT) mice previously subjected to a 9-day sham stress (A) or water avoidance stress (WAS; B). Effect of intra-antral infusion of saline at 0°C on VMR to CRD in TRPA1 knockout (KO) mice previously subjected to sham stress (C) or WAS (D). Data are expressed as mean ± SEM of VMR expressed as % of 60 mmHg response in the baseline set of CRD on day 0. n = 9–10 per group. *P < 0.05, **P < 0.01 at CRD pressures of 45 mmHg and 60 mmHg (2-way ANOVA followed by Bonferroni post-test comparisons).
Journal of Neurogastroenterology and Motility 2019;25:442~460 https://doi.org/10.5056/jnm19014
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