Journal of Neurogastroenterology and Motility : eISSN 2093-0887 / pISSN 2093-0879

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Fig. 3. Representative photomicrographs for segmental hypoganglionosis cases with other specific features. (A, B) A segmental hypoganglionosis case with eosinophilic ganglionitis (patient No. 24). Colonic segment distal to the transition zone shows reddish discoloration (arrow) (A). Several eosinophils are observed along the hypoganglionic myenteric plexus (arrow) (B) (H&E, ×20 objective lens, scale bar = 100 μm). (C, D) A segmental hypoganglionosis case with cytomegalovirus (CMV) infection (patient No. 16). Several geographic ulcers (arrow) are observed in distal ganglionated segment (arrow) (C). CMV immunostaining reveals several CMV inclusions (brown dots) (D) (CMV immunohistochemistry, ×20 objective lens, scale bar = 100 μm). (E, F) A segmental hypoganglionosis case with ischemia (patient No. 12). Proximal dilated segment shows reddish mucosal discoloration and loss of semilunar folds (E). Transmural ischemic changes are seen (F) (H&E, ×4 objective lens, scale bar = 500 μm). (G, H) An intestinal pseudo-obstruction case with transition zone without hypoganglionosis (patient No. 38). Marked dilatation of proximal colon with prominent transition zone (G). Heterotopic ganglions are observed in outer longitudinal muscle layer (arrows) (H) (H&E, ×4 objective lens, scale bar = 500 μm).
Journal of Neurogastroenterology and Motility 2019;25:137~147 https://doi.org/10.5056/jnm18121
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