Journal of Neurogastroenterology and Motility 2013 Jan; 19(1): 36-41
| Effects of Ramosetron on Gastrointestinal Transit of Guinea Pig |
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| Yoo Mi Park,1 Young Ju Lee,1 Young Ho Lee,2 Tae Il Kim1 and Hyojin Park1* |
| Departments of 1Internal Medicine and 2Physiology, Yonsei University College of Medicine, Seoul, Korea |
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| Background/Aims
A selective 5-hydroxytryptamine (5-HT) type 3 receptor antagonist, ramosetron, inhibits stress-induced abnormal defecation in
animals and is currently used as a therapeutic drug for irritable bowel syndrome with diarrhea. The aim of this study is to
investigate the effect of ramosetron on altered gastrointestinal (GI) transit.
Methods
Male guinea pigs weighing approximately 300 g were used. The effect of ramosetron was investigated on altered GI transit
induced by thyrotropin-releasing hormone (TRH), 5-HT, or mustard oil (MO). GI transit was evaluated by the migration of charcoal
mixture from the pylorus to the most distal point, and expressed as a percentage (%) of charcoal migration (cm) of the
total length of total small intestine (cm).
Results
The average charcoal transit was 51.3 ± 20.1% in the control (vehicle) group, whereas in the ramosetron group charcoal
moved 56.6 ± 21.9%, 46.9 ± 9.14% and 8.4 ± 5.6% of the total small intestine at the concentrations of 10, 30 and 100
μg/kg, respectively. GI transit after administration of TRH (100 μg/kg), 5-HT (10 mg/kg) or MO (10 mg/kg) was accelerated
compared to vehicle (5-HT, 94.9 ± 9.22%; TRH, 73.4 ± 14.7%; MO, 81.0 ± 13.7%). Ramosetron inhibited GI transit altered
by 5-HT, TRH or MO.
Conclusions
Ramosetron modulated GI transit. We suggest that ramosetron may be therapeutically useful for those with accelerated upper
GI transit. |
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Journal of Neurogastroenterology and Motility 2013 Jan; 19(1): 36-41  |
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| Keyword : Gastrointestinal transit; Mustard oil; Ramosetron; Serotonin 5-HT3 receptor antagonist; Thyrotropin-releasing hormone |
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